1.
Chem Commun (Camb)
; 51(24): 5104-7, 2015 Mar 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25715179
RESUMO
Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.