Evaluation of the Acute and Subacute Toxicity of Aqueous Extract of Coriandrum sativum L. Seeds in Wistar Rats.

BACKGROUND: In traditional herbal medicine, the Coriandrum sativum (CS) seeds are widely used to prevent and/or treat several diseases. Despite this, research into studying their toxicity is very limited. OBJECTIVE: This study aims at studying the acute and subacute toxicity of aqueous extract of coriander seeds (AECS) in Wistar rats. METHODS: For acute toxicity, five dose levels (500, 1000, 2000, 3000, and 5000 mgkg-1bw) were tested per single oral administration. Subacute toxicity for 28 days was achieved by daily oral administration of AECS at doses of 1000, 2000, and 3000 mgkg-1bw. RESULTS: No deaths or signs were recorded or observed in rats in the five groups and the control group was after 14 days of acute toxicity study. The results of subacute toxicity revealed that the administration of AECS caused a significant difference in the body weight of rats at doses of 2000 and 3000mgkg-1bw, and in the development of movement disturbances, hypoactivity, drowsiness, weakness, and diarrhea, while histopathological examination showed vascular congestion and inflammation of the kidneys as well as hepatic necrosis. The haematological profile showed a significant increase in the number of red and white blood cells, haemoglobin, haematocrit, and a nonsignificant decrease is noticed in neutrophils at a dose of 3000 mgkg-1bw. CONCLUSION: AECS should be used with caution as it has caused some signs of toxicity and may affect the liver and kidneys if doses are repeated. However, further studies are needed to verify and clarify the toxic aspect of Coriandrum sativum L. seeds.

The dynamics of the nematode Anguillicola crassus, Kuvahara 1974 in eel Anguilla anguilla (L. 1758) in the Sebou estuary (Morocco).

The European eel is a vulnerable fish by its complex life cycle, by the impact of pollution of the near total of freshwater aquatic environments, and by the gravity and the diversity of its parasites (nematodes, cestodes, trematodes, the Copepoda, Coccidia...). It is classified in the red book of threatened species. The anguillulose is the principal parasitic pathology of an eel either in the natural environment or in the aquaculture. The eels taken in the three zones of the Sebou estuary of varied environmental conditions were dissected for the research of parasites. Of the fish, 85.7% are infested upstream of the estuary, whereas only 71% shelter this parasite in their swim bladder, with an abundance of 2.09 per fish downstream and 83.8 in zone 2. The present study suggests the development stage of the fish, and therefore its diet, has an influence on the parasitic infestation. The estuaries and the lagoons constitute a very significant medium for the safeguarding and the disinfection of parasitized eels.