RESUMO
Nephrogenic systemic fibrosis (NSF) is a rare disease that can present in patients with kidney injury who have been exposed to gadolinium-based contrast agents (GBCAs). These patients can easily be misdiagnosed as having another disease because they do not fit the usual presentation of being on hemodialysis. We report a case of NSF occurring in a patient with resolved transient renal insufficiency and no history of chronic renal disease.
Assuntos
Dermopatia Fibrosante Nefrogênica , Insuficiência Renal , Meios de Contraste/efeitos adversos , Gadolínio/efeitos adversos , Humanos , Imageamento por Ressonância Magnética , Dermopatia Fibrosante Nefrogênica/induzido quimicamente , Dermopatia Fibrosante Nefrogênica/diagnóstico , Insuficiência Renal/diagnósticoAssuntos
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Cloridrato de Erlotinib/efeitos adversos , Neoplasias Pulmonares/tratamento farmacológico , Melanoma/induzido quimicamente , Nevo Pigmentado/induzido quimicamente , Inibidores de Proteínas Quinases/efeitos adversos , Neoplasias Cutâneas/induzido quimicamente , Idoso , Carcinoma Pulmonar de Células não Pequenas/patologia , Humanos , Neoplasias Pulmonares/patologia , Masculino , Melanoma/patologia , Nevo Pigmentado/patologia , Neoplasias Cutâneas/patologiaAssuntos
Hemangioma/patologia , Neoplasias Cutâneas/patologia , Abdome , Adulto , Feminino , HumanosRESUMO
Relapsing polychondritis (RP) is an inflammatory condition that has been widely accepted as autoimmune in nature and can occur in patients with immune system dysregulation. Although RP has been well documented in patients with other autoimmune conditions, such as vasculitis, its presence in patients with human immunodeficiency virus (HIV) infection has been infrequently described. We describe a case of RP in an HIV-positive patient without other identifiable autoimmune disease.
Assuntos
Infecções por HIV , Policondrite Recidivante/diagnóstico , Adulto , Dapsona/administração & dosagem , Dapsona/uso terapêutico , Diagnóstico Diferencial , Orelha Externa/patologia , Humanos , Masculino , Policondrite Recidivante/tratamento farmacológicoRESUMO
Necrobiosis lipoidica (NL) is a granulomatous inflammatory skin disease strongly associated with diabetes mellitus (DM). Red-brown papules expanding into plaques with erythematous indurated borders on the lower extremities are characteristic of NL. Diagnosis is made clinically; however, biopsy of lesions confirms the diagnosis. Untreated NL may ulcerate and lead to further complications, but progression to superimposed pyoderma vegetans (PV) is not a known occurrence.
Assuntos
Necrobiose Lipoídica/patologia , Pioderma/patologia , Adulto , Antibacterianos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Betametasona/análogos & derivados , Betametasona/uso terapêutico , Cefalexina/uso terapêutico , Feminino , Humanos , Mupirocina/uso terapêutico , Necrobiose Lipoídica/terapia , Pioderma/terapia , Dermatopatias Bacterianas/patologia , Dermatopatias Bacterianas/terapiaRESUMO
Multinucleate cell angiohistiocytoma is a rare, vascular, fibrohistiocytic proliferation that has a benign but progressive course. The clinical presentation is that of grouped red-purple papules and nodules characteristically located on the lower extremities in women. The histopathology shows a proliferation of narrow vessels within thickened collagen bundles associated with multinucleate giant cells. These lesions are probably reactive in nature, and several mechanisms of pathogenesis, including hormonal, have been proposed. Different modalities, including intense pulsed light and pulsed-dye laser, have been used for treatment of these lesions. We report a case of a 74-year-old Caucasian woman with long-standing multinucleate angiohistiocytoma on her bilateral thighs that eluded diagnosis for several years. Upon biopsy and histopathological analysis, the diagnosis was made. Treatment options were entertained, although ultimately not pursued by the patient. We report this case to increase clinical awareness of this rare disease and to contribute to the ongoing literature aimed to further characterize this condition.
Assuntos
Hemangioma , Histiocitoma , Neoplasias Cutâneas , Idoso , Biópsia , Feminino , Hemangioma/diagnóstico , Hemangioma/metabolismo , Hemangioma/patologia , Histiocitoma/diagnóstico , Histiocitoma/metabolismo , Histiocitoma/patologia , Humanos , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologiaAssuntos
Dermatofibrossarcoma/diagnóstico , Sarcoma/diagnóstico , Pele/patologia , Tumores Fibrosos Solitários , Idoso , Dorso , Biópsia/métodos , Procedimentos Cirúrgicos Dermatológicos/métodos , Diagnóstico Diferencial , Dissecação/métodos , Humanos , Masculino , Tumores Fibrosos Solitários/diagnóstico , Tumores Fibrosos Solitários/patologia , Tumores Fibrosos Solitários/cirurgiaRESUMO
Lichen planus (LP) is a mucocutaneous inflammatory dermatitis of idiopathic origin that can involve the skin, mucous membranes, hair, and nails. LP has an associated set of characteristic histopathologic findings which include hyperkeratosis, vacuolization of the basal layer, Civatte bodies, wedge-shaped hypergranulosis, band-like lymphocytic infiltrate at the dermal epidermal junction, eosinophilic colloid bodies in the papillary dermis, and pigment incontinence. The infiltrate is usually composed of lymphocytes with few histiocytes, mast cells, and macrophages. The presence of plasma cell predominant infiltrate in LP has only been reported in four previous cases and 2 other cases of lichen nitidus. The authors report another 2 cases of LP with predominate plasma cell infiltrate in 2 female patients on the legs. The differential includes a drug-induced lichenoid reaction with predominate plasma cell infiltrate. However, there have been no case reports of that type of reaction. Because plasma cells are seen commonly in certain infectious diseases, malignancy, and macroglobulinemia, it is prudent to rule out those entities. Our patients responded well with a class 1 topical steroid, with improvement of their lower leg lesions within 1 month of treatment.
Assuntos
Líquen Plano/patologia , Plasmócitos/patologia , Idoso , Feminino , HumanosAssuntos
Adenocarcinoma Mucinoso/tratamento farmacológico , Inibidores da Aromatase/uso terapêutico , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Recidiva Local de Neoplasia/tratamento farmacológico , Nitrilas/uso terapêutico , Couro Cabeludo , Neoplasias Cutâneas/tratamento farmacológico , Triazóis/uso terapêutico , Adenocarcinoma Mucinoso/patologia , Adenocarcinoma Mucinoso/cirurgia , Idoso de 80 Anos ou mais , Anastrozol , Feminino , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Cirurgia de Mohs , Indução de Remissão , Couro Cabeludo/cirurgia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Falha de TratamentoAssuntos
Líquen Nítido/diagnóstico , Pele/patologia , Criança , Humanos , Líquen Nítido/patologia , Adulto JovemRESUMO
Rosai-Dorfman Disease (RDD) is a rare, idiopathic lymphoproliferative disorder. Central nervous system (CNS) involvement in this disorder is an uncommon manifestation. The clinical and radiographic appearance of CNS RDD is variable, and may mimic more common diseases. Treatment is controversial, and spontaneous remission is common. Positive outcomes have been reported with radiation therapy, or corticosteroid administration, or surgical excision. Our case is unusual in that the extracranial sites of involvement responded to corticosteroid therapy while the intracranial masses progressed.
Assuntos
Histiocitose Sinusal/diagnóstico , Meios de Contraste , Diagnóstico Diferencial , Feminino , Gadolínio DTPA , Histiocitose Sinusal/terapia , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XRESUMO
Polyarteritis nodosa (PAN) is a systemic vasculitis which may result in thrombosis or aneurysm formation in any organ of the body. We report a case polyarteritis nodosa (PAN) resulting in bilateral asynchronous testicular necrosis. A 55-year-old male developed acute onset of left testicular pain resulting in a left orchiectomy and right orchidopexy for an ischemic left testicle without evidence of torsion. Three weeks later, the patient developed acute right-sided scrotal pain, and surgical exploration revealed a right necrotic testicle resulting in a right orchiectomy. Pathologic evaluations demonstrated benign testes with acute interstitial hemorrhage and focal atrophy. The patient also experienced abdominal skin necrosis, penile pain and swelling, and temporary loss of vision. This is a unique case of PAN and the only case of asynchronous testicular necrosis in the medical literature.