[Adjuvant therapy in rectal cancer]. / Adjuvantní terapie u karcinomu rekta.

BACKGROUNDS: Rectal cancer treatment has noticed several important changes in last years. TME, new radiotherapy techniques and new systemic agents have been introduced. Preoperative staging has improved. Nevertheless the neoadjuvant treatment approach is not unified all over the world. MATERIAL AND METHODS: Using the following American and European guidelines we found primary citations and compared their results. CONCLUSION: Currently, there are substantial differences in neoadjuvant dose of radiotherapy between European and American guidelines. Short neoadjuvant course of radiotherapy seems to be appropriate in patients with smaller primary operable rectal cancer.This approach is safe if chosen, not oppressing stage III patients by protracted oncological treatment including chemotherapy.

[Modern radiotherapy in the complex management of soft tissue and bone sarcomas in adults--current overview and the author's experience]. / Moderní radioterapie v komplexní lécbe sarkomu mekkých tkání a kostí u dospelých--aktuální prehled a vlastní zkusenosti.

Soft tissue sarcomas and primary bone tumours constitute very heterogenic group. Gold treatment standard is surgery in most of them. Nowadays the combination surgery with radiotherapy is preferred, because thanks new radiotherapeutic technology is possible to apply very high dose of radiation which necessary for local control of these tumours. The goal of our article is to describe new possibilities of radiotherapy, including neoadjuvant and adjuvant setting, intraoperative radiotherapy, interstitial brachytherapy and the combination with surgery. But very important is multidisciplinary cooperation to until recently in prognostic bad group of patients, concentration these patients to centers with modern technique and clinical experience with treatment of soft tissue sarcomas and bone tumours.