RESUMO
Navajo children disproportionately experience poor asthma outcomes. Following a one-year community engagement period with key stakeholders from the Navajo Nation, the Community Asthma Program (CAP) was created using evidenced based programs with the goal of reducing asthma disparities among Navajo children. CAP is being evaluated with a six-year, multi-site step-wedge design in three Navajo communities: Tuba City, Chinle and Fort Defiance, Arizona. The primary outcome is asthma exacerbations defined as use of systemic oral corticosteroids, asthma hospitalizations, asthma related ED visits, and ICU admissions. Asthma exacerbations will be measured using data from the electronic medical records of the three community health care centers. Secondary outcomes include will changes in asthma-related events and asthma control. The RE-AIM ( R each and representativeness, 2) E ffectiveness, 3) A doption, 4) I mplementation, and 5) M aintenance) framework is being used to guide the implementation evaluation which includes iterative collection and analysis of process data to identify facilitators and barriers, describe relevant organizational contexts, and inform strategies for dissemination. The CAP intervention requires community engagement and participation, building community capacity, incorporating evidenced-based guidelines and practices while ensuring program strategies actively involve Navajo community members during all steps of the intervention. The outcome of this trial will allow us to determine the effectiveness of a multi-component, community-focused intervention to improve asthma in a tribal community.
Assuntos
Má Oclusão/fisiopatologia , Mandíbula/fisiopatologia , Avanço Mandibular/instrumentação , Músculo Esquelético/metabolismo , Síndromes da Apneia do Sono/fisiopatologia , Eletromiografia/métodos , Desenho de Equipamento , Humanos , Masculino , Pessoa de Meia-Idade , Sono/fisiologia , Resultado do TratamentoRESUMO
In a curved tube, the amount of airflow appears to be influenced by the amount of curvature. The purpose of this study was to investigate changes in obstructive sleep apnoea (OSA) severity and awake velopharyngeal curvature in response to an anteriorly titrated mandibular position in 20 male OSA patients. Baseline supine cephalometry was obtained before the initial insertion of a titratable oral appliance and follow-up supine cephalometry was undertaken after titration of the mandibular position with the appliance in place. The mean apnoea/hypopnea index (AHI) before treatment (31.6 +/- 13.0 events x h(-1)) was significantly reduced (9.8 +/- 7.4 events x h(-1)) after titration of the mandibular position in all 20 patients. There was a significant increase in the anteroposterior calibre and the radius of the curvature of the anterior wall of the velopharynx in 14 good responders who exhibited an AHI reduction to < or = 15. Similar observations were not found in six poor responders. To conclude, an anteriorly titrated mandibular position reduced obstructive sleep apnoea severity, enlarged the velopharynx and diminished the curvature of the anterior velopharyngeal wall in good responders. It is proposed that this change in the upper airway curvature associated with mandibular advancement may effect obstructive sleep apnoea severity through its effect on airflow dynamics.
Assuntos
Obstrução das Vias Respiratórias/terapia , Avanço Mandibular/instrumentação , Apneia Obstrutiva do Sono/terapia , Adolescente , Adulto , Obstrução das Vias Respiratórias/diagnóstico , Obstrução das Vias Respiratórias/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Palato Mole/fisiopatologia , Faringe/fisiopatologia , Polissonografia , Apneia Obstrutiva do Sono/diagnóstico , Apneia Obstrutiva do Sono/fisiopatologia , Resultado do Tratamento , Insuficiência Velofaríngea/diagnóstico , Insuficiência Velofaríngea/fisiopatologia , Insuficiência Velofaríngea/terapia , Dimensão VerticalRESUMO
The purpose of this study was to investigate whether any physiologic or cephalometric parameters could be used to predict the efficacy of an adjustable mandibular advancement appliance for treating obstructive sleep apnea (OSA). Forty-two male and 5 female patients with OSA were recruited on the basis of baseline polysomnography with a documented Apnea and Hypopnea Index (AHI) greater than 15 per hour. Repeat polysomnography was performed with the appliance in place. Baseline cephalometry was performed for each patient, and follow-up cephalometry was completed for 19 of the subjects. The subjects were divided into 3 groups on the basis of the degree of change in the AHI with oral appliance therapy: good response (> 75% decrease in AHI), moderate response (25% to 75% decrease in AHI), and poor response (< 25% decrease in AHI). Patients with a good response were younger and had smaller upper airways. In a linear regression analysis, the change in AHI (%) was associated with physiologic (age and body mass index), cephalometric (overjet, height of the maxillary molars, vertical height of the hyoid bone), and airway variables. However, changes in either overbite or overjet were not related to changes in any of the polysomnographic variables for the 19 subjects. A stepwise regression analysis revealed a better treatment response with the adjustable mandibular advancement appliance in patients who were younger and had a lower body mass index, a longer maxilla, a smaller oropharynx, a smaller overjet, less erupted maxillary molars, and a larger ratio of vertical airway length to the cross-sectional area of the soft palate.
Assuntos
Avanço Mandibular/instrumentação , Placas Oclusais , Apneia Obstrutiva do Sono/terapia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Índice de Massa Corporal , Cefalometria , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Polissonografia , Prognóstico , Análise de Regressão , Apneia Obstrutiva do Sono/patologia , Estatísticas não ParamétricasRESUMO
STUDY OBJECTIVES: To define morphological changes in the upper airway and its surrounding structures after the insertion of a titratable mandibular repositioner. DESIGN: Ten non-apneic adult males participated in this study. A set of supine lateral cephalograms was taken for each subject at the end of expiration with a titratable oral appliance in place in four mandibular positions: most retruded (RP), maximum protrusion (MAX), 33% of MAX (MAX33), and 67% of MAX (MAX67). Changes in the anteroposterior width of the upper airway, positions of the hyoid bone and the third cervical vertebra were compared between the four mandibular positions. An ANOVA was used to test for statistical significance. SETTING: N/A. PATIENTS OR PARTICIPANTS: N/A. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: The anteroposterior width of the velopharynx significantly increased when the mandible was advanced from RP to MAX67 and MAX. However, there were no significant changes in the anteroposterior width of the oropharynx. Significant forward displacement of the hyoid bone and third cervical vertebra together with the mandible was found in MAX67 and MAX compared to RP. CONCLUSION: Especially in MAX67 and MAX, the titratable oral appliance significantly enlarges upper airway size in the velopharynx and results in a forward displacement of the hyoid bone and the third cervical vertebra.
Assuntos
Aparelhos Ortodônticos Removíveis , Apneia Obstrutiva do Sono/prevenção & controle , Decúbito Dorsal , Vigília , Adulto , Cefalometria/métodos , Vértebras Cervicais/fisiologia , Humanos , Masculino , Avanço Mandibular/métodos , Palato Mole/fisiologiaRESUMO
The aim was to test the hypothesis of a direct association between sleep-disordered breathing and sleep bruxism. The frequency of masseter contraction (MC) episodes and rhythmic jaw movements (RJM) was measured in patients with mild and moderate obstructive sleep apnoea (OSA). The diagnosis of sleep bruxism was made from a combination of questionnaire, clinical observation and all-night polysomnographic recording which included masseter electromyography. A total of 21 patients (19 males/two females, mean age 40.0 years+/-9.2 SD) were randomly selected from a provisional diagnosis of snoring and OSA by a sleep physician. In the patients with mild OSA [n=11, mean apnoea hypopnoea index (AHI)=8.0+/-4.1 SD, body mass index (BMI)=29.1+/-5.0], the diagnosis of sleep bruxism was made in six out of 11 patients (54%); similarly, four out of 10 patients (40%) with moderate OSA (n=10, mean AHI=34.7+/-19.1, BMI=30.6+/-5.0) were identified as bruxists. Although the combination of clinical, subjective estimation and nocturnal electromyographic recording of masseter muscle might provide a more solid base for the diagnosis of sleep bruxism, the result is biased by the variation in the bruxing activity. MC episodes were associated with the termination of apnoea or hypopnoea episodes in only 3.5% of the mild group and 14.4% of the moderate group (p<0.05). It appears that sleep bruxism is rarely directly associated with apnoeic events, but is rather related to the disturbed sleep of OSA patients.
Assuntos
Síndromes da Apneia do Sono/complicações , Bruxismo do Sono/etiologia , Adulto , Viés , Índice de Massa Corporal , Eletromiografia , Feminino , Humanos , Masculino , Mandíbula/fisiopatologia , Músculo Masseter/fisiopatologia , Movimento , Contração Muscular/fisiologia , Polissonografia , Síndromes da Apneia do Sono/fisiopatologia , Bruxismo do Sono/diagnóstico , Bruxismo do Sono/fisiopatologia , Ronco/complicações , Ronco/fisiopatologia , Estatística como Assunto , Inquéritos e QuestionáriosRESUMO
The purpose of this study was to investigate the effects of a mandibular repositioner on airway, sleep, and respiratory variables in patients with obstructive sleep apnea. Twenty-two patients selected for this study were confirmed with a diagnosis of obstructive sleep apnea based on initial nocturnal polysomnography. The patients were fitted with a mandibular repositioner designed to hold the mandible anteroinferiorly. Six months later, an outcome polysomnographic study was undertaken for each patient with the appliance in place. Lateral cephalometric radiographs in the upright position were also obtained before and after 6 months of treatment. The respiratory disturbance index decreased in 21 of the 22 patients with the appliance in place. The mean respiratory disturbance index of the 22 patients decreased significantly from 40.3 to 11.7 events per hour (P <.01). Some 59.1% of subjects were considered a treatment success with follow-up respiratory disturbance index < 10 events per hour. The mean minimum blood oxygen saturation level during sleep also improved significantly from 73.4% to 81.3% (P <. 01). The mandibular repositioner was constructed to position the mandible at 75% of the maximal mandibular advancement and with a 7 mm opening between the upper and lower incisors, and no aberrant effect on temporomandibular joint was noted. The retropalatal airway space increased and the cross-sectional area of the soft palate and the vertical distance of the hyoid bone to the mandibular plane decreased significantly. The tongue posture became significantly flatter. A significant linear correlation was found between the reduction in apnea index and specific craniofacial skeletal structures (length of anterior cranial base, mandibular plane angle, and upper to lower facial height ratios, P <.05). Subjects with a smaller reduction in apnea index tended to have shorter anterior cranial bases, steeper mandibular planes, and smaller upper to lower facial height ratios. We conclude that a mandibular repositioner may be an effective treatment alternative for obstructive sleep apnea and that a reduction in the frequency of apneic episodes is mainly attributed to the effects of the appliance on oropharyngeal structures.
Assuntos
Placas Oclusais , Apneia Obstrutiva do Sono/terapia , Adulto , Idoso , Cefalometria , Desenho de Equipamento , Humanos , Modelos Lineares , Avanço Mandibular/instrumentação , Pessoa de Meia-Idade , Satisfação do Paciente , Polissonografia , Ronco/terapia , Inquéritos e Questionários , Resultado do TratamentoRESUMO
STUDY OBJECTIVES: To measure the effects of a titratable anterior mandibular repositioner on airway size and Obstructive Sleep Apnea (OSA) and to evaluate its compliance. DESIGN: Before and after insertion sleep studies were obtained in a total of 38 OSA patients of varying severity from three different sites. Covert compliance was measured by means of a newly-developed, miniaturized, temperature-sensitive, imbedded monitor. Validity testing was completed in six adult volunteers who wore monitors imbedded into small acrylic appliances. MEASUREMENTS AND RESULTS: The mean RDI before treatment was 32.6 (SEM 2.1) and after the insertion of the appliance, the RDI was reduced to 12.1 (SEM 1.7, p<0.001). RDI was reduced to less than 15/hour in 80% of a group of moderate OSA patients (RDI 15 to 30) and in 61% of a group of severe OSA patients (RDI > 30) with respect to baseline RDI. Fiber optic video endoscopy was performed on 9 OSA patients with and without the appliance. No significant differences in hypopharynx or oropharynx cross sectional areas were found, but at the level of the velopharynx, the airway size was significantly increased (p<0.05). The index of agreement was 0.99 between the monitor clock time and the subject's log sheets. Compliance data from eight OSA subjects instructed to wear the appliance during sleep indicated that it was worn for a mean of 6.8 hours with a range of 5.6 to 7.5 hours per night. CONCLUSION: The titratable adjustable mandibular advancement appliance, made from thermoelastic acrylic, significantly reduces RDI in moderate to severe OSA patients, has a direct effect on airway size and is well worn throughout the night.
Assuntos
Avanço Mandibular/instrumentação , Apneia Obstrutiva do Sono/terapia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cooperação do Paciente , Respiração com Pressão Positiva/métodos , Índice de Gravidade de Doença , Apneia Obstrutiva do Sono/diagnóstico , Sono REM/fisiologiaRESUMO
The purpose of this study was to compare two groups of adult men from different ethnic backgrounds and with obstructive sleep apnea; they were selected by matching age, gender, skeletal pattern, body mass index, and respiratory disturbance index. Pretreatment cephalometric radiographs and overnight polysomnograms of 30 Chinese and 43 Caucasian patients with Class II, Division 1 malocclusions were analyzed to investigate if there were craniofacial and upper airway structural differences between the two ethnic groups. The Chinese group, when compared with the group of Caucasian patients, revealed more severe underlying craniofacial skeletal discrepancies with significantly smaller maxilla and mandibles, more severe mandibular retrognathism, proclined lower incisors, increased total and upper facial heights, and steeper and shorter anterior cranial bases. However, no significant differences were found between the two groups in posterior facial height, ratio of upper to lower anterior facial height, and the position of hyoid bone, maxilla, and upper incisors. With regard to soft tissue and upper airway measurements, there were no significant ethnic differences in tongue and soft palate size, vertical length of oropharynx, and anteroposterior dimensions of the upper airway at most of the levels except for a larger super-posterior airway space, a larger nasopharynx and oropharynx cross-sectional area, and a smaller tongue height in the Chinese group. We conclude that there are a number of craniofacial and upper airway structures that differ between the two ethnic groups that may be relevant to the treatment of obstructive sleep apnea in various ethnic groups.
Assuntos
Povo Asiático , Cefalometria , Apneia Obstrutiva do Sono/etnologia , População Branca , Índice de Massa Corporal , Colúmbia Britânica , Cefalometria/estatística & dados numéricos , China , Humanos , Masculino , Má Oclusão Classe II de Angle/diagnóstico , Má Oclusão Classe II de Angle/etnologia , Pessoa de Meia-Idade , Polissonografia , Apneia Obstrutiva do Sono/diagnósticoRESUMO
AIM: The purpose of this study was to investigate whether any physiological or cephalometric parameters could be used to predict the efficacy of the Klearway oral appliance (OA) for the treatment of obstructive sleep apnea (OSA). METHODS: Forty-two male and 5 female patients with OSA were recruited on the basis of baseline polysomnography with a documented Apnea and Hypopnea Index (AHI) > 15 per hour. Repeat polysomnography was performed with the appliance in place. Baseline cephalometry was performed for each patient. Subjects were divided into 3 groups on the basis of the degree of change in AHI with OA therapy: good response (> 75% decrease in AHI), moderate response (25% to 75% decrease range in AHI), and poor response (< 25% decrease in AHI). RESULTS: Patients with a good response were younger and had smaller upper airways. A stepwise regression analysis revealed that a better treatment response with the Klearway appliance was obtained in patients who were younger and had a lower body mass index, a longer maxilla, a smaller oropharynx, a smaller overjet, less erupted maxillary molars, and larger ratio of vertical airway length to the cross-sectional area of the soft palate.
Assuntos
Terapia Miofuncional/instrumentação , Síndromes da Apneia do Sono/terapia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Apneia/fisiopatologia , Índice de Massa Corporal , Cefalometria , Desenho de Equipamento , Feminino , Previsões , Humanos , Osso Hioide/patologia , Masculino , Má Oclusão/patologia , Mandíbula/patologia , Maxila/patologia , Pessoa de Meia-Idade , Dente Molar/patologia , Orofaringe/patologia , Palato Mole/patologia , Polissonografia , Análise de Regressão , Síndromes da Apneia do Sono/patologia , Síndromes da Apneia do Sono/fisiopatologia , Estatística como Assunto , Língua/patologia , Resultado do TratamentoRESUMO
OBJECTIVES: To determine the shape difference of the face and tongue of obstructive sleep apnea (OSA) patients, in comparison to those of non-apneic patients. DESIGN: Retrospective analysis of observational data on a cohort of patients. SETTING: A university teaching hospital and sleep referral center. SAMPLE POPULATION AND METHOD: Eighty patients referred for overnight polysomnography and lateral cephalometry and who met the selection criteria were included. Upright and supine cephalograms were obtained and subgrouped based on the severity of clinical symptoms. Shape differences between the groups were assessed by a multiple analysis of variance and a Hotelling's T2. MEASUREMENTS AND RESULTS: A set of anatomical landmarks were selected for outlines of the face and the tongue on cephalograms. X and Y coordinates of each landmark were utilized as variables. As symptoms become severe, the hyoid bone and the submental area positioned inferiorly and the fourth vertebra relocated posteriorly with respect to the lower mandibular border. When subjects changed their body position from the upright to the supine, the posterior part of the tongue appeared to sink down. The hyoid bone position to epiglottis-retrognathion line in the supine position distinguishes OSA patients from non-apneic subjects. CONCLUSION: Despite many limitations, we demonstrate that the supine cepahlometrics during wakefulness can be a useful adjunctive diagnostic tool for OSA, when cephalograms are analyzed in a coordinate data form.
Assuntos
Cefalometria , Face/anatomia & histologia , Apneia Obstrutiva do Sono/patologia , Língua/anatomia & histologia , Adulto , Análise de Variância , Humanos , Masculino , Pessoa de Meia-Idade , Postura , Índice de Gravidade de DoençaRESUMO
BACKGROUND: The mechanisms of action of oral appliance therapy in obstructive sleep apnoea are poorly understood. Videoendoscopy of the upper airway was used during wakefulness to examine whether the changes in pharyngeal dimensions produced by a mandibular advancement oral appliance are related to the improvement in the severity of obstructive sleep apnoea. METHODS: Fifteen patients with mild to moderate obstructive sleep apnoea (median (range) apnoea index (AI) 4(0-38)/h, apnoea-hypopnoea index (AHI) 28(9-45)/h) underwent overnight polysomnography and imaging of the upper airway before and after insertion of the oral appliance. Images were obtained in the hypopharynx, oropharynx, and velopharynx at end tidal expiration during quiet nasal breathing in the supine position. The cross sectional area and diameters of the upper airway were measured using image processing software with an intraluminal catheter as a linear calibration. RESULTS: AI decreased to a median (range) value of 0 (0-6)/h (p<0.01) and AHI to 8 (1-28)/h (p<0.001) following insertion of the oral appliance. The median (95% confidence interval) cross sectional area of the upper airway increased by 18% (3 to 35) (p<0.02) in the hypopharynx and by 25% (11 to 69) (p<0.005) in the velopharynx, but not significantly in the oropharynx. Although in general the shape of the pharynx did not change following insertion of the oral appliance, the lateral diameter of the velopharynx increased to a greater extent than the anteroposterior diameter. Following insertion of the oral appliance the reduction in AHI was related to the increase in cross sectional area of the velopharynx (p = 0.01). CONCLUSIONS: A mandibular advancement oral appliance increases the cross sectional area of the upper airway during wakefulness, particularly in the velopharynx. Assuming this effect on upper airway calibre is not eliminated by sleep, mandibular advancement oral appliances may reduce the severity of obstructive sleep apnoea by maintaining patency of the velopharynx, particularly in its lateral dimension.
Assuntos
Avanço Mandibular/instrumentação , Faringe/fisiopatologia , Síndromes da Apneia do Sono/terapia , Adulto , Idoso , Humanos , Pessoa de Meia-Idade , Polissonografia , Síndromes da Apneia do Sono/fisiopatologiaRESUMO
Vertical mandibular posture is thought to be related to narrowing of the upper airway, because mouth opening is associated with an inferior-posterior movement of the mandible and the tongue which influences pharyngeal airway patency. To test whether the mandibular posture is related to the occurrence and/or termination of obstructive sleep apnoea (OSA), the vertical mandibular position was recorded intraorally using a magnet sensor during a standard sleep study in seven patients with OSA. Measurements were recorded during sleep both in the supine and lateral recumbent positions. The percentage of total sleep time spent with mandibular opening greater than 5 mm was significantly larger (p<0.001) in patients with OSA (69.3+/-23.3%) compared with our previous results obtained from healthy adults without OSA (11.1+/-11.6%). The stage of sleep affected the vertical mandibular posture during sleep in the supine position, but not in the lateral recumbent position in patients with OSA. In non-rapid eye-movement sleep, mandibular opening increased progressively during apnoeic episodes and decreased at the termination of apnoeic episodes. In contrast, no significant change in mandibular posture occurred in apnoeic episodes during rapid eye-movement sleep. It was concluded that the vertical mandibular posture is more open during sleep in patients with OSA than in healthy adults and that mandibular opening increases progressively during apnoeic episodes and decreases at the termination of those episodes.
Assuntos
Mandíbula/fisiologia , Síndromes da Apneia do Sono/fisiopatologia , Análise de Variância , Fenômenos Biomecânicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polissonografia , Sono REM/fisiologia , Decúbito Dorsal/fisiologia , Fatores de TempoRESUMO
Clinicians have long suspected that tongue shape differs between obstructive sleep apnea (OSA) patients and normal subjects. The purpose of this study was to determine whether such differences exist. Because of the difficulty in specifying reproducible homologous landmarks for the tongue, a morphometric technique-the eigenshape analysis-was used. The eigenshape analysis transforms an outline contour into a set of discrete numbers that are tangent angles of the curvature along the outline at each digitized point on the outline. Pairs of cephalograms were taken of 80 male patients in upright and supine positions. The subjects were subgrouped into four categories according to severity of symptoms. The contour of the tongue was traced, digitized, and subgrouped. When the major portion of the tongue shape variations in the supine position were graphically compared between subgroups, variations in the nonapneic group were distinguished from those in the apneic groups. The results suggest that the eigenshape analysis on cephalograms in the supine position may be a useful tool to distinguish OSA subjects from nonapneic subjects.
Assuntos
Cefalometria/instrumentação , Síndromes da Apneia do Sono/diagnóstico , Língua/patologia , Adulto , Cefalometria/normas , Humanos , Masculino , Pessoa de Meia-Idade , Postura , Padrões de Referência , Síndromes da Apneia do Sono/patologiaRESUMO
To test whether the mandible opens more during deep sleep and whether the mandibular position is affected by body position during sleep, the vertical mandibular position was recorded intraorally using a magnet sensor at the same time as a standard sleep study in seven normal healthy male adults. Measurements were recorded during the period before sleep onset (WAKE) and during sleep. Two-way ANOVA showed that vertical mandibular position was significantly affected by sleep stage but not by body position (supine vs lateral recumbent). The proportion of time during which the mandible was in a near-closed position (0-2.5 mm) significantly and progressively decreased, and significantly more time was spent at wider gaps (2.5-5 mm) as non-rapid-eye-movement (NREM) sleep deepened. In REM sleep, the proportion of time during which the mandible was at wider gaps was significantly greater than in WAKE and stage 1 (but not later stages) of NREM sleep. It was concluded that mandibular posture during sleep in healthy adults is significantly influenced by sleep stage but not by body position. Mandibular opening progressively increases with the depth of NREM sleep stage, and the mandible is more open in REM sleep than in light NREM sleep.
Assuntos
Mandíbula/fisiologia , Fases do Sono/fisiologia , Adulto , Análise de Variância , Humanos , Magnetismo/instrumentação , Masculino , Polissonografia/instrumentação , Polissonografia/métodos , Polissonografia/estatística & dados numéricos , Postura/fisiologia , Valores de Referência , Fatores de TempoRESUMO
Mandibular deficiency may be a factor in reduced oropharyngeal airway (OAW) dimensions and related impaired respiratory function. The purpose of this study was to evaluate the use of functional-orthopedic devices in increasing OAW dimensions in children with Class II skeletal patterns (ANB > 4) and clinically deficient mandibles. Comparisons were made between two groups, one comprising 26 treated patients and the other comprising 15 controls. Student's t-tests, paired t-tests, discriminant analyses, and Pearson's r-correlation coefficients were performed to evaluate group differences and to search for characteristics that might suggest which patients would be better candidates for significant increase in OAW dimensions. Compared with controls, OAW dimensions increased significantly in treated patients, especially those with sagittally smaller and more retrognathic maxillomandibular complexes and smaller OAW dimensions.
Assuntos
Obstrução das Vias Respiratórias/etiologia , Má Oclusão Classe II de Angle/complicações , Orofaringe/patologia , Retrognatismo/complicações , Aparelhos Ativadores , Obstrução das Vias Respiratórias/terapia , Estudos de Casos e Controles , Cefalometria , Criança , Análise Discriminante , Feminino , Humanos , Masculino , Má Oclusão Classe II de Angle/terapia , Mandíbula/anormalidades , Desenvolvimento Maxilofacial , Orofaringe/crescimento & desenvolvimento , Orofaringe/fisiopatologia , Reprodutibilidade dos Testes , Retrognatismo/terapia , Estatísticas não ParamétricasRESUMO
Enlarged tonsils, adenoids, and chronic respiratory problems have been associated with the compensatory adaptations of natural head posture (NHP) in children. Recently, it has been shown that adult patients with Obstructive Sleep Apnoea (OSA) also tend to exhibit a craniocervical extension (CCE) with a forward head posture (FHP). This study was designed to search for some characteristics of OSA patients that may be related to these adaptive changes in NHP. Overnight polysomnographic, demographic, and cephalometric records of 252 adult male subjects with various types of skeletal patterns and dental conditions were examined. Apnoea Index (AI) and Apnoea + Hypopnoea Index (AHI) variables were assessed to separate the non-apnoeic snorers (n = 35), and mild (n = 101), moderate (n = 63), and severe (n = 53) OSA groups. Results of the Tukey tests revealed that severe OSA patients had a greater tendency to exhibit a CCE with a FHP (P < or = 0.05 to P < or = 0.001). Differences in head extension (NSL.VER) between groups could not be identified. Pearson's 'r' correlation coefficients revealed that the CCE and FHP in OSA patients were associated with a higher disease severity, a longer and larger tongue, a lower hyoid bone position in relation to the mandibular plane, a smaller nasopharyngeal and a larger hypopharyngeal cross-sectional area, and a higher body mass index (P < or = 0.05 to P < or = 0.001). It is concluded that a CCE with a FHP is more likely to be seen in severe and obese OSA patients with certain morphological characteristics of the upper airway and related structures.
Assuntos
Cabeça , Postura , Síndromes da Apneia do Sono/fisiopatologia , Adulto , Idoso , Análise de Variância , Constituição Corporal , Cefalometria , Vértebras Cervicais/fisiopatologia , Humanos , Osso Hioide/patologia , Hipofaringe/patologia , Masculino , Pessoa de Meia-Idade , Nasofaringe/patologia , Pescoço/patologia , Músculos do Pescoço/fisiopatologia , Obesidade/complicações , Palato Mole/patologia , Polissonografia , Índice de Gravidade de Doença , Síndromes da Apneia do Sono/complicações , Síndromes da Apneia do Sono/patologia , Estatísticas não Paramétricas , Língua/patologiaRESUMO
BACKGROUND: Although oral appliances are effective in some patients with obstructive sleep apnoea (OSA), they are not universally effective. A novel anterior mandibular positioner (AMP) has been developed with an adjustable hinge that allows progressive advancement of the mandible. The objective of this prospective crossover study was to compare efficacy, side effects, patient compliance, and preference between AMP and nasal continuous positive airway pressure (nCPAP) in patients with symptomatic mild to moderate OSA. METHODS: Twenty four patients of mean (SD) age 44.0 (10.6) years were recruited with a mean (SD) body mass index of 32.0 (8.2) kg/m2, Epworth sleepiness score 10.7 (3.4), and apnoea/hypopnoea index 26.8 (11.9)/hour. There was a two week wash-in and a two week wash-out period and two treatment periods (AMP and nCPAP) each of four months. Efficacy, side effects, compliance, and preference were evaluated by a questionnaire and home sleep monitoring. RESULTS: One patient dropped out early in the study and three refused to cross over so treatment results are presented on the remaining 20 patients. The apnoea/hypopnoea index (AHI) was lower with nasal CPAP 4.2 (2.2)/hour than with the AMP 13.6 (14.5)/hour (p < 0.01). Eleven of the 20 patients (55%) who used the AMP were treatment successes (reduction of AHI to < 10/hour and relief of symptoms), one (5%) was a compliance failure (unable or unwilling to use the treatment), and eight (40%) were treatment failures (failure to reduce AHI to < 10/hour and/or failure to relieve symptoms). Fourteen of the 20 patients (70%) who used nCPAP were treatment successes, six (30%) were compliance failures, and there were no treatment failures. There was greater patient satisfaction with the AMP (p < 0.01) than with nCPAP but no difference in reported side effects or compliance. CONCLUSIONS: AMP is an effective treatment in some patients with mild to moderate OSA and is associated with greater patient satisfaction than nCPAP.