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1.
Psychol Rev ; 2024 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-38722599

RESUMO

Implicit leadership theories (ILTs) are people's lay theories, definitions, or conceptualizations of leadership. In adults, they determine what actions we perceive as leadership, influence to whom we grant leadership status, and shape our own behaviors when we want to be seen as leader. Naturally, there has been an enduring interest in how these ILTs develop in children. Current theorizing on the development of leadership conceptualizations in children aligns with a stepwise progression mirroring Piaget's stage-based approach to cognitive development. However, contemporary approaches to cognitive development, such as Siegler's overlapping waves theory (OWT), acknowledge that children's development is linked to cognitive success and failure. This article integrates the findings from empirical studies into children's leadership conceptualizations and reinterprets them against OWT. This reinterpretation resolves findings that align poorly with a stepwise approach and demonstrates a strong fit with OWT. As such, children's leadership conceptualizations develop by generating and testing cognitive approaches-physical-spatiotemporal, functional, socioemotional, and humanitarian-and instead of progressing through these in order and according to age, they display variation and selection, that with experience and exposure, lay down selective combinations, which often engage multiple dimensions simultaneously. Consequently, the development of children's understanding of leaders is nonlinear, can be multidimensional, and is based on trial and error largely in response to their experiences. The article concludes with a discussion of the implications for future research and practice. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

2.
Crit Care Nurs Clin North Am ; 34(4): 395-407, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36336430

RESUMO

Chronic kidney disease (CKD) is a widespread condition that predisposes patients to a myriad of complications, including cardiovascular disease, electrolyte and acid-base derangements, anemia, mineral-bone disease, and volume excess. The frequency of CKD complications increases with the stage of disease, becoming nearly ubiquitous in later stages. The complications of CKD have profound implications for patient management, laboratory monitoring, medication prescribing, and follow up. Management of CKD seeks to slow disease progression and mitigate the risks posed by these complications.


Assuntos
Anemia , Doenças Cardiovasculares , Insuficiência Renal Crônica , Humanos , Insuficiência Renal Crônica/complicações , Anemia/etiologia , Doença Crônica , Progressão da Doença
3.
Nano Converg ; 7(1): 38, 2020 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-33301056

RESUMO

Upper gastrointestinal (GI) carcinomas are characterized as one of the deadliest cancer types with the highest recurrence rates. Their treatment is challenging due to late diagnosis, early metastasis formation, resistance to systemic therapy and complicated surgeries performed in poorly accessible locations. Current cancer medication face deficiencies such as high toxicity and systemic side-effects due to the non-specific distribution of the drug agent. Nanomedicine has the potential to offer sophisticated therapeutic possibilities through adjusted delivery systems. This review aims to provide an overview of novel approaches and perspectives on nanoparticle (NP) drug delivery systems for gastrointestinal carcinomas. Present regimen for the treatment of upper GI carcinomas are described prior to detailing various NP drug delivery formulations and their current and potential role in GI cancer theranostics with a specific emphasis on targeted nanodelivery systems. To date, only a handful of NP systems have met the standard of care requirements for GI carcinoma patients. However, an increasing number of studies provide evidence supporting NP-based diagnostic and therapeutic tools. Future development and strategic use of NP-based drug formulations will be a hallmark in the treatment of various cancers. This article seeks to highlight the exciting potential of novel NPs for targeted cancer therapy in GI carcinomas and thus provide motivation for further research in this field.

4.
Addict Behav Rep ; 11: 100246, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32467835

RESUMO

AIMS: This paper explores inter-generational changes in consumers smoking product uptake and use patterns after the introduction of e-cigarettes and hookahs. DESIGN: Item Response Theory (IRT) is used to analyze the Health Information National Trends Survey sponsored by the Food and Drug Administration (HINTS-FDA). The survey was fielded in 2015. IRT allows the pattern of product use to be described and help assess whether the new tobacco products (i.e., e-cigarettes, hookahs) serve as gateway to other products or act in harm reduction modality. FINDINGS: The results indicate that the new product alternatives have changed the how tobacco products are adopted in the U.S. In particular, younger respondents were more likely to have engaged in cigar, e-cigarette and water-pipe use than the older cohort. CONCLUSIONS: The introduction of nicotine products previously unavailable in the U.S is creating new modes for smoking initiation in the age groups most likely to begin a new habit. There is little evidence that smokers in the older HINTS cohorts are using the e-cigarette as a smoking cessation tool. The rise of cigar use in the younger cohort may indicate that legal products are being mixed with illicit substances (i.e., 'blunting').

5.
Nurse Pract ; 45(1): 18-26, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31764241

RESUMO

Pain is routinely reported in patients with chronic kidney disease. Pain is often multifaceted, making the treatment of this complex patient population even more challenging. Understanding pain types as well as treatment options for this patient population is an important skillset for the primary care provider.


Assuntos
Manejo da Dor/métodos , Atenção Primária à Saúde , Insuficiência Renal Crônica/terapia , Humanos , Profissionais de Enfermagem , Dor/etiologia , Medição da Dor , Insuficiência Renal Crônica/complicações , Terminologia como Assunto
6.
J Med Internet Res ; 20(8): e10458, 2018 08 07.
Artigo em Inglês | MEDLINE | ID: mdl-30087090

RESUMO

BACKGROUND: The Meaningful Use (MU) program has promoted electronic health record adoption among US hospitals. Studies have shown that electronic health record adoption has been slower than desired in certain types of hospitals; but generally, the overall adoption rate has increased among hospitals. However, these studies have neither evaluated the adoption of advanced functionalities of electronic health records (beyond MU) nor forecasted electronic health record maturation over an extended period in a holistic fashion. Additional research is needed to prospectively assess US hospitals' electronic health record technology adoption and advancement patterns. OBJECTIVE: This study forecasts the maturation of electronic health record functionality adoption among US hospitals through 2035. METHODS: The Healthcare Information and Management Systems Society (HIMSS) Analytics' Electronic Medical Record Adoption Model (EMRAM) dataset was used to track historic uptakes of various electronic health record functionalities considered critical to improving health care quality and efficiency in hospitals. The Bass model was used to predict the technological diffusion rates for repeated electronic health record adoptions where upgrades undergo rapid technological improvements. The forecast used EMRAM data from 2006 to 2014 to estimate adoption levels to the year 2035. RESULTS: In 2014, over 5400 hospitals completed HIMSS' annual EMRAM survey (86%+ of total US hospitals). In 2006, the majority of the US hospitals were in EMRAM Stages 0, 1, and 2. By 2014, most hospitals had achieved Stages 3, 4, and 5. The overall technology diffusion model (ie, the Bass model) reached an adjusted R-squared of .91. The final forecast depicted differing trends for each of the EMRAM stages. In 2006, the first year of observation, peaks of Stages 0 and 1 were shown as electronic health record adoption predates HIMSS' EMRAM. By 2007, Stage 2 reached its peak. Stage 3 reached its full height by 2011, while Stage 4 peaked by 2014. The first three stages created a graph that exhibits the expected "S-curve" for technology diffusion, with inflection point being the peak diffusion rate. This forecast indicates that Stage 5 should peak by 2019 and Stage 6 by 2026. Although this forecast extends to the year 2035, no peak was readily observed for Stage 7. Overall, most hospitals will achieve Stages 5, 6, or 7 of EMRAM by 2020; however, a considerable number of hospitals will not achieve Stage 7 by 2035. CONCLUSIONS: We forecasted the adoption of electronic health record capabilities from a paper-based environment (Stage 0) to an environment where only electronic information is used to document and direct care delivery (Stage 7). According to our forecasts, the majority of hospitals will not reach Stage 7 until 2035, absent major policy changes or leaps in technological capabilities. These results indicate that US hospitals are decades away from fully implementing sophisticated decision support applications and interoperability functionalities in electronic health records as defined by EMRAM's Stage 7.


Assuntos
Registros Eletrônicos de Saúde/tendências , Hospitais/tendências , Qualidade da Assistência à Saúde/normas , Humanos , Estudos Retrospectivos , Estados Unidos
7.
Health Care Manage Rev ; 43(1): 61-68, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-27280583

RESUMO

BACKGROUND: The relationship between Chief Executive Officer (CEO) succession and hospitals' competitive performance is an area of interest for health services researchers. Of particular interest is the impact on overall strategic direction and health system performance that results from selecting a CEO from inside the firm as opposed to seeking outside leadership. Empirical work-to-date has yielded mixed results. Much of this variability has been attributed to design flaws; however, in the absence of a clear message from the evidence, the preference for hiring "outsiders" continues to grow. PURPOSE: This paper investigates on the extent to which insider CEO succession versus outsider succession impacts hospitals' competitive advantage vis-à-vis a sample of organizations that compete in the same sector. METHODS: A hospital matching protocol based on propensity scores is used to control for endogeneity and makes comparisons of productivity across organizations through the use of stochastic frontier estimation. FINDINGS: Succession negatively impacts hospitals' productivity, and firms with outsider CEO succession events closed the gap toward the competitive advantage frontier faster than comparable firms with insider successions. PRACTICE IMPLICATIONS: More research needs to be done on succession planning and its impact on CEO turnover.


Assuntos
Mobilidade Ocupacional , Diretores de Hospitais/tendências , Eficiência Organizacional , Hospitais/estatística & dados numéricos , Pessoal Administrativo , Competição Econômica/economia , Competição Econômica/estatística & dados numéricos , Humanos , Liderança , Seleção de Pessoal/organização & administração , Inquéritos e Questionários
8.
J Emerg Med ; 54(1): 16-24, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29107479

RESUMO

BACKGROUND: Infection is the second leading cause of death in end-stage renal disease (ESRD) patients. Prior investigations of acute septic shock in this specific population are limited. OBJECTIVE: We aimed to evaluate the clinical presentation and factors associated with outcome among ESRD patients with acute septic shock. METHODS: We reviewed patients prospectively enrolled in an emergency department (ED) septic shock treatment pathway registry between January 2014 and May 2016. Clinical and treatment variables for ESRD patients were compared with non-ESRD patients. A second analysis focused on ESRD septic shock survivors and nonsurvivors. RESULTS: Among 4126 registry enrollees, 3564 (86.4%) met inclusion for the study. End-stage renal disease was present in 3.8% (n = 137) of ED septic shock patients. Hospital mortality was 20.4% and 17.1% for the ESRD and non-ESRD septic shock patient groups (p = 0.31). Septic shock patients with ESRD had a higher burden of chronic illness, but similar admission clinical profiles to non-ESRD patients. End-stage renal disease status was independently associated with lower fluid resuscitation dose, even when controlling for severity of illness. Age and admission lactate were independently associated with mortality in ESRD septic shock patients. CONCLUSION: ESRD patients comprise a small but important portion of patients with ED septic shock. Although presentation clinical profiles are similar to patients without ESRD, ESRD status is independently associated with lower fluid dose and compliance with the 30-mL/kg fluid goal. Hyperlactatemia is a marker of mortality in ESRD septic shock.


Assuntos
Falência Renal Crônica/mortalidade , Choque Séptico/mortalidade , Idoso , Idoso de 80 Anos ou mais , Diálise/métodos , Serviço Hospitalar de Emergência/organização & administração , Feminino , Mortalidade Hospitalar , Humanos , Falência Renal Crônica/complicações , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde/tendências , Ressuscitação/métodos , Análise de Sobrevida
9.
J Med Pract Manage ; 32(2): 86-91, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-29944795

RESUMO

This was a retrospective, cross-sectional study to determine whether a relationship exists between work relative value unit(wRVU) awareness and wRVU accumulation among faculty physicians. Physician wRVU awareness was obtained by a distributed survey to faculty physicians in early 2016. wRVU accumulation was pulled from a faculty productivity database. Productivity data from FY14-FY15 was used to determine wRVU accumulation relative to each respondent's specialty-specific benchmark. Data were analyzed to investigate the nature, of the relationship between awareness and accumulation. The analysis showed that physicians with above-average awareness were significantly more likely to surpass their wRVU benchmark when compared to physicians with below-average awareness. Additionally, wRVU awareness accounted for a significant percentage of the variation in wRVU output. Considering the financial importance of wRVU generation for healthcare organizations, there is a need to devote more time and resources to developing physician awareness of wRVUs.


Assuntos
Conscientização , Docentes de Medicina/psicologia , Padrões de Prática Médica/estatística & dados numéricos , Escalas de Valor Relativo , Centros Médicos Acadêmicos , Estudos Transversais , Eficiência , Eficiência Organizacional , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Inquéritos e Questionários , Estados Unidos
10.
Phys Occup Ther Pediatr ; 35(4): 342-53, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25529410

RESUMO

AIMS: To determine whether electrical stimulation (ES) following botulinum toxin A (BoNT/A) injection increases passive extensibility of the hamstring muscles in children with spastic diplegia. METHODS: Six children undergoing bilateral BoNT/A injections to the hamstrings participated in this within-participant single blind randomized controlled trial. One leg of each child was randomised to the experimental condition and the other to the control condition. The experimental leg received daily stretch and ES to the hamstrings for 12 weeks, while the control leg received only daily stretch. The primary outcome was passive hamstring extensibility reflected by popliteal angle measured with a standardised torque. Secondary outcomes were two goniometric measures of popliteal angle using the Modified Tardieu Scale (R1 and R2), and parents' perceptions of treatment effectiveness. Outcomes were measured at baseline, 4 weeks, 12 weeks and 6 months. RESULTS: The mean between-group difference (95% CI) at 4 weeks was 2° (-2 to 5) for popliteal angle measured with a standardised torque, favouring the experimental leg. Tardieu results for R1 and R2 were 0° (-4 to 3) and 7° (0 to 14), respectively. CONCLUSION: ES does not improve passive extensibility of the hamstring muscles at 4 weeks over any possible effects of BoNT/A alone.


Assuntos
Toxinas Botulínicas Tipo A/uso terapêutico , Paralisia Cerebral/terapia , Terapia por Estimulação Elétrica , Músculo Esquelético/fisiopatologia , Fármacos Neuromusculares/uso terapêutico , Adolescente , Criança , Pré-Escolar , Terapia Combinada , Feminino , Humanos , Articulação do Joelho/fisiopatologia , Masculino , Exercícios de Alongamento Muscular , Projetos Piloto , Amplitude de Movimento Articular , Método Simples-Cego , Falha de Tratamento
11.
J Surg Oncol ; 106(6): 724-7, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22549809

RESUMO

BACKGROUND AND OBJECTIVES: The Ki-67 index has been incorporated into The World Health Organization's classification system of pancreatic neuroendocrine tumors. However, pathologists continue to question the utility of Ki-67 index over that of mitotic count as an indicator of proliferative activity. The intent of the current study is to compare K-i67 index with tumor size and mitotic rate for the association of each with lymph node metastasis and survival. METHODS: The current study is a review of 24 patients with pancreatic neuroendocrine tumors. RESULTS: Regional LNM were present in 100% of tumors with Ki-67 index >10%, while only 25% of tumors with <10% Ki-67 had LNM (P = 0.003). No tumors <2 cm had >10% Ki-67 labeling. Of patients with tumors showing ≥ 10% Ki-67 labeling, 80% died during the observation period of this study, while during the same time period, no patients with <10% Ki-67 labeling died. CONCLUSION: Ki-67 index of >10% is a sensitive indicator of malignant behavior and mortality. Future advances in management of pNETs will require development of staging guidelines with higher predictive value. Inclusion of Ki-67 labeling >10% as an indicator of aggressive disease may contribute to such improvements.


Assuntos
Antígeno Ki-67/análise , Mitose , Tumores Neuroendócrinos/patologia , Neoplasias Pancreáticas/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Tumores Neuroendócrinos/química , Neoplasias Pancreáticas/química , Fenótipo
13.
Am Surg ; 77(5): 545-51, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21679585

RESUMO

It is advocated that a favorable outcome for pancreaticoduodenectomy (PD) is related to a high volume at university centers. This article examines the specific elements that allow an equivalent outcome from PD in a nonuniversity tertiary care center (NUTCC). The study was performed to: (1) evaluate the outcome of PDs done at a NUTCC; (2) study the components of the process that are required to attain success in a NUTCC; and (3) provide a new look at the volume-outcome relationships in complex surgeries in a novel nonuniversity setting. Medical records of patients who underwent PD by a single surgeon between September 2005 and August 2008 at a high-volume NUTCC were analyzed. The records were reviewed with respect to preoperative and postoperative data, 30-day mortality, morbidity, and histopathology data. A total of 122 patients underwent PD. The mean age was 68.2 years. Jaundice was the most common presenting symptom in 57 per cent (69 patients). Thirty-nine patients (32%) underwent a pylorus-preserving PD. The mean operative time was 237 minutes. The mean estimated blood loss was 480 mL. The mean length hospital stay was 13 days. Thirty-day mortality was 3.2 per cent (four patients) and overall morbidity was 49 per cent. The key factors in developing a team dedicated to the care of the patient undergoing PD are discussed. A center of excellence can be developed in a NUTCC resulting in outcomes that meet and indeed may exceed nationally reported benchmarks. The key elements to success include a team approach to the patient undergoing PD.


Assuntos
Competência Clínica , Mortalidade Hospitalar/tendências , Pancreaticoduodenectomia/mortalidade , Pancreaticoduodenectomia/estatística & dados numéricos , Carga de Trabalho , Idoso , Idoso de 80 Anos ou mais , Benchmarking , Estudos de Viabilidade , Feminino , Seguimentos , Pesquisas sobre Atenção à Saúde , Hospitais/estatística & dados numéricos , Hospitais Públicos/estatística & dados numéricos , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Neoplasias Pancreáticas/cirurgia , Pancreaticoduodenectomia/efeitos adversos , Pancreaticoduodenectomia/métodos , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/fisiopatologia , Estudos Retrospectivos , Medição de Risco , Gestão da Segurança , Análise de Sobrevida , Resultado do Tratamento
14.
Crit Care Med ; 38(6): 1458-66, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20400904

RESUMO

OBJECTIVE: Lung inflammation causes perivascular fluid cuffs to form around extra-alveolar blood vessels; however, the physiologic consequences of such cuffs remain poorly understood. Herein, we tested the hypothesis that perivascular fluid cuffs, without concomitant alveolar edema, are sufficient to decrease lung compliance. DESIGN: Prospective, randomized, controlled study. SETTING: Research laboratory. SUBJECTS: One hundred twenty male CD40 rats. INTERVENTIONS: To test this hypothesis, the plant alkaloid thapsigargin was used to activate store-operated calcium entry and increase cytosolic calcium in endothelium. Thapsigargin was infused into a central venous catheter of intact, sedated, and mechanically ventilated rats. MEASUREMENTS: Static and dynamic lung mechanics and hemodynamics were measured continuously. MAIN RESULTS: Thapsigargin produced perivascular fluid cuffs along extra-alveolar vessels but did not cause alveolar flooding or blood gas abnormalities. Lung compliance dose-dependently decreased after thapsigargin infusion, attributable to an increase in tissue resistance that was attributed to increased tissue damping and tissue elastance. Airway resistance was not changed. Neither central venous pressure nor left ventricular end diastolic pressure was altered by thapsigargin. Heart rate did not change, although thapsigargin decreased left ventricular systolic function sufficient to reduce cardiac output by 50%. Infusion of the type 4 phosphodiesterase inhibitor, rolipram, prevented thapsigargin from inducing perivascular cuffs and decreasing lung compliance. Rolipram also normalized pressure over time and corrected the deficit in cardiac output. CONCLUSIONS: Our findings resolve for the first time that perivascular cuff formation negatively impacts mechanical coupling between the bronchovascular bundle and the lung parenchyma, decreasing lung compliance without impacting central venous pressure.


Assuntos
Lesão Pulmonar Aguda/etiologia , Permeabilidade Capilar/fisiologia , Água Extravascular Pulmonar/fisiologia , Complacência Pulmonar/fisiologia , Edema Pulmonar/etiologia , Mecânica Respiratória/fisiologia , Lesão Pulmonar Aguda/metabolismo , Lesão Pulmonar Aguda/patologia , Animais , Permeabilidade Capilar/efeitos dos fármacos , Inibidores Enzimáticos/farmacologia , Água Extravascular Pulmonar/efeitos dos fármacos , Complacência Pulmonar/efeitos dos fármacos , Masculino , Inibidores de Fosfodiesterase/farmacologia , Edema Pulmonar/metabolismo , Edema Pulmonar/patologia , Ratos , Mecânica Respiratória/efeitos dos fármacos , Rolipram/farmacologia , Tapsigargina/farmacologia , Resistência Vascular/efeitos dos fármacos , Resistência Vascular/fisiologia
15.
Antioxid Redox Signal ; 11(4): 765-76, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18783312

RESUMO

Rises in cytosolic calcium are sufficient to initiate the retraction of endothelial cell borders and to increase macromolecular permeability. Although endothelial cell biologists have recognized the importance of shifts in cytosolic calcium for several decades, only recently have we gained a rudimentary understanding of the membrane calcium channels that change cell shape. Members of the transient receptor potential family (TRP) are chief among the molecular candidates for permeability-coupled calcium channels. Activation of calcium entry through store-operated calcium entry channels, most notably TRPC1 and TRPC4, increases lung endothelial cell permeability, as does activation of calcium entry through the TRPV4 channel. However, TRPC1 and TRPC4 channels appear to influence the lung extraalveolar endothelial barrier most prominently, whereas TRPV4 channels appear to influence the lung capillary endothelial barrier most prominently. Thus, phenotypic heterogeneity in ion channel expression and function exists within the lung endothelium, along the arterial-capillary-venous axis, and is coupled to discrete control of endothelial barrier function.


Assuntos
Endotélio/fisiologia , Pulmão/fisiologia , Canais de Potencial de Receptor Transitório/fisiologia , Sequência de Aminoácidos , Animais , Cálcio/metabolismo , Permeabilidade da Membrana Celular , Endotélio/metabolismo , Insuficiência Cardíaca/metabolismo , Insuficiência Cardíaca/fisiopatologia , Humanos , Pulmão/metabolismo , Dados de Sequência Molecular , Canais de Potencial de Receptor Transitório/química , Canais de Potencial de Receptor Transitório/metabolismo
16.
J Bone Joint Surg Am ; 90(1): 23-33, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18171954

RESUMO

BACKGROUND: Cerebral palsy is the most common cause of childhood physical disability in developed countries, affecting two children per 1000 live births. Hip displacement affects about one-third of children with cerebral palsy and may result in pain, deformity, and impaired function. The prevention of hip displacement has not been studied in a randomized trial as far as we know. METHODS: A randomized, controlled trial was conducted to examine the effect of intramuscular injections of botulinum toxin A combined with use of a variable hip abduction brace on the progression of hip displacement in children with cerebral palsy. The patients in the treatment group received injections of botulinum toxin A to the adductor and hamstring muscles every six months for three years and were prescribed a hip abduction brace to be worn for six hours per day. In the control group, no hip bracing was used nor were injections performed. The primary outcome measure was hip displacement from the acetabulum as determined by serial measurements of the migration percentage. RESULTS: Ninety children with bilateral cerebral palsy and so-called hips at risk (a migration percentage of >10% but <40%) were entered into the study. Fifty-nine patients were boys, and the mean age was three years. Progressive hip displacement, as determined by serial measurements of the migration percentage, was found in both the treatment and control groups. The rate of hip displacement was reduced in the treatment group by 1.4% per year (95% confidence interval, -0.6% to 3.4%; p = 0.16) when weighted for the uncertainty in rates due to the differing numbers of migration percentage measurements per subject. CONCLUSIONS: There may be a small treatment benefit for the combined intervention of intramuscular injection of botulinum toxin A and abduction hip bracing in the management of spastic hip displacement in children with cerebral palsy. However, progressive hip displacement continued to occur in the treatment group, and our data do not support recommending this treatment.


Assuntos
Toxinas Botulínicas Tipo A/uso terapêutico , Braquetes , Paralisia Cerebral/diagnóstico , Luxação Congênita de Quadril/diagnóstico , Luxação Congênita de Quadril/terapia , Amplitude de Movimento Articular/fisiologia , Toxinas Botulínicas Tipo A/efeitos adversos , Paralisia Cerebral/complicações , Pré-Escolar , Terapia Combinada , Relação Dose-Resposta a Droga , Esquema de Medicação , Feminino , Seguimentos , Luxação Congênita de Quadril/complicações , Humanos , Lactente , Injeções Intramusculares , Modelos Lineares , Masculino , Probabilidade , Valores de Referência , Medição de Risco , Índice de Gravidade de Doença , Resultado do Tratamento
17.
Dev Med Child Neurol ; 49(11): 823-9, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17979860

RESUMO

The efficacy of repeated botulinum toxin A (BTX-A) injections in two and three dose regimes, together with occupational therapy, on upper limb movement and function, was studied using an evaluator blinded, randomized, controlled two-group trial. Forty-two children (31 males, 11 females; range 2-8 y, mean 4 y [SD 1 y 7 mo]) with hemiplegic cerebral palsy (Gross Motor Function Classification System Level I) longitudinally participated for 30 months, with the first 6 months reported earlier (Lowe et al. 2006). The BTX-A group (n=21) received three injections (0, 6, and 18 mo), while the delayed group had two (6 and 18 mo; dose 0.5-2.1 units/kg, mean 1.5 [SD 0.18]; dilution 100 units/0.5 ml). At 30 months, no difference existed between groups on any standardized measures. First and second injections showed significant treatment effect sizes, on Quality of Upper Extremity Skills Test (5.5 p=0.01: 4.5 p=0.03); parent Goal Attainment Scaling (GAS; 3.5 p=0.02: 3.9 p=0.01; therapist GAS 7.8 p=0.00: 4.0 p=0.03); Canadian Occupational Performance Measure (performance 0.4 p=0.05: 0.4 p=0.02; satisfaction 0.4 p=0.05: 0.37 p=0.08); and Pediatric Evaluation of Disability Inventory functional skills (1.8 p=0.00: 2.3 p=0.04). BTX-A was not linked to adverse events, suggesting repeated upper limb injections in children with hemiplegia receiving occupational therapy were safe and effective for improvement of movement and function.


Assuntos
Toxinas Botulínicas Tipo A/uso terapêutico , Paralisia Cerebral/tratamento farmacológico , Paralisia Cerebral/fisiopatologia , Fármacos Neuromusculares/uso terapêutico , Extremidade Superior/fisiopatologia , Toxinas Botulínicas Tipo A/administração & dosagem , Toxinas Botulínicas Tipo A/efeitos adversos , Criança , Método Duplo-Cego , Feminino , Humanos , Injeções Intramusculares , Masculino , Fármacos Neuromusculares/administração & dosagem , Fármacos Neuromusculares/efeitos adversos , Estudos Prospectivos
18.
J Surg Res ; 143(1): 70-7, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17950075

RESUMO

BACKGROUND: In acute respiratory distress syndrome, pulmonary vascular permeability increases, causing intravascular fluid and protein to move into the lung's interstitium. The classic model describing the formation of pulmonary edema suggests that fluid crossing the capillary endothelium is drawn by negative interstitial pressure into the potential space surrounding extra-alveolar vessels and, as interstitial pressure builds, is forced into the alveolar air space. However, the validity of this model is challenged by animal models of acute lung injury in which extra-alveolar vessels are more permeable than capillaries under a variety of conditions. In the current study, we sought to determine whether extravascular fluid accumulation can be produced because of increased permeability of either the capillary or extra-alveolar endothelium, and whether different pathophysiology results from such site-specific increases in permeability. MATERIALS AND METHODS: We perfused isolated lungs with either the plant alkaloid thapsigargin, which increases extra-alveolar endothelial permeability, or with 4alpha-phorbol 12, 13-didecanoate, which increases capillary endothelial permeability. RESULTS: Both treatments produced equal increases in whole lung vascular permeability, but caused fluid accumulations in separate anatomical compartments. Light microscopy of isolated lungs showed that thapsigargin caused fluid cuffing of large vessels, while 4alpha-phorbol 12, 13-didecanoate caused alveolar flooding. Dynamic compliance was reduced in lungs with cuffing of large vessels, but not in lungs with alveolar flooding. CONCLUSIONS: Phenotypic differences between vascular segments resulted in site-specific increases in permeability, which have different pathophysiological outcomes. Our findings suggest that insults leading to acute respiratory distress syndrome may increase permeability in extra-alveolar or capillary vascular segments, resulting in different pathophysiological sequela.


Assuntos
Permeabilidade da Membrana Celular/fisiologia , Células Endoteliais/patologia , Pulmão/irrigação sanguínea , Alvéolos Pulmonares/patologia , Edema Pulmonar/fisiopatologia , Síndrome do Desconforto Respiratório/fisiopatologia , Animais , Carcinógenos/farmacologia , Permeabilidade da Membrana Celular/efeitos dos fármacos , Modelos Animais de Doenças , Células Endoteliais/fisiologia , Inibidores Enzimáticos/farmacologia , Água Extravascular Pulmonar/fisiologia , Pulmão/efeitos dos fármacos , Pulmão/patologia , Complacência Pulmonar/fisiologia , Masculino , Ésteres de Forbol/farmacologia , Alvéolos Pulmonares/fisiopatologia , Edema Pulmonar/etiologia , Edema Pulmonar/patologia , Ratos , Ratos Sprague-Dawley , Síndrome do Desconforto Respiratório/etiologia , Síndrome do Desconforto Respiratório/patologia , Mecânica Respiratória/fisiologia , Tapsigargina/farmacologia
19.
Am J Occup Ther ; 61(4): 463-8, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17685179

RESUMO

Occupational therapy home programs are a common approach used to provide interventions for children with cerebral palsy, but there is little evidence to demonstrate the effectiveness of such programs. This single-group pretest-posttest design pilot study evaluated the impact of an occupational therapy home program implemented with 20 children who had spastic hemiplegic cerebral palsy (ages 2-7 years, mean 3.8). We measured impact using Goal Attainment Scaling (GAS), the Pediatric Evaluation of Disability Inventory (PEDI), and the Quality of Upper Extremity Skills Test (QUEST). We measured participation amount through a parent self-report log. Significant changes following intervention occured in scores on the GAS, the PEDI Functional Skills and Caregiver Assistance Scales, and the QUEST, but has found no relationship between participation amount and outcome using the same measures. These promising results suggest that further investigation of the impact of occupational therapy home programs is warranted.


Assuntos
Paralisia Cerebral/classificação , Assistência Domiciliar/organização & administração , Terapia Ocupacional/métodos , Paralisia Cerebral/reabilitação , Criança , Pré-Escolar , Avaliação da Deficiência , Feminino , Humanos , Masculino , Terapia Ocupacional/organização & administração , Projetos Piloto
20.
Disabil Rehabil ; 29(10): 761-6, 2007 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-17457734

RESUMO

BACKGROUND: The Canadian Occupational Performance Measure (COPM) is a commonly used outcome measure in rehabilitation. In this study it was adapted for very young children by deleting paid/unpaid work and household management categories and having parents act as proxies to rate child performance and their own satisfaction. PURPOSE: To assess the internal consistency reliability, content and construct validity, responsiveness, and impact of half scores (20 not 10-point scale) of the adapted COPM. METHOD: Parent proxies of subjects aged 2 - 8 (mean 3.9) years with spastic hemiplegic cerebral palsy (n = 41) participating in a clinical trial. There was a total of 214 occupational performance problems for analysis and an additional 56 which had used half score ratings. Internal consistency reliability and construct validity were evaluated using Cronbach alpha statistic. Proxy views explored content validity. Responsiveness was evaluated using pre-post intervention scores and a comparison with Goal Attainment Scaling scores which were assumed to be a suitable benchmark measure. The effect of half scores was assessed by two-sample t-tests. RESULTS: The COPM adaptations did not have a negative impact on internal consistency reliability as this was acceptable for performance (0.73) and satisfaction (0.83). The high Cronbach alpha scores indicated good construct validity. Content of occupations and rating approach was considered valid by proxies. Use of half scores did not result in significantly different performance ratings, but mean satisfaction ratings were significantly higher when half scores were used (p = 0.0001). This suggests that half scores may provide more precise proxy satisfaction ratings, but at the cost of rigour as internal consistency with satisfaction half scores was lower (0.63 vs. 0.82). Responsiveness to change in clinical status was demonstrated by significant pre-post scores and moderate correlations with goal attainment scores. CONCLUSION: The adapted COPM is a psychometrically robust tool and the use of half scores is not recommended.


Assuntos
Paralisia Cerebral/reabilitação , Terapia Ocupacional/métodos , Psicometria/métodos , Canadá , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pediatria , Ensaios Clínicos Controlados Aleatórios como Assunto
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