1.
J Surg Res
; 32(2): 168-72, 1982 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7057634
Assuntos
Corticosteroides/uso terapêutico , Ácido Clorídrico/farmacologia , Pneumonia Aspirativa/tratamento farmacológico , Respiração , Animais , Artérias , Água Corporal , Cães , Feminino , Pulmão/patologia , Pulmão/fisiopatologia , Masculino , Oxigênio , Pressão Parcial , Pneumonia Aspirativa/induzido quimicamente
2.
Surgery
; 90(2): 376-80, 1981 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7020139
RESUMO
Enhancement of nonspecific host defenses against bacterial challenge has been a long-standing goal often thwarted by variable efficacy, inconsistent bioassay, and paradoxic immunosuppression. Muramyl dipeptide provides enhanced survival after intravenous challenge with less than 8 x 10(3) Klebsiella, as well as improved local control of infection at sites of intramuscular bacterial injection, with and without a surgical foreign body. No depression of host response was seen over wide ranges of doses and intervals. Muramyl dipeptide provides a new order of efficacy and safety and warrants continued careful assessment.