RESUMO
Lymphatic and portal venous absorption of gastrically administered thiopental and phenobarbital were compared in the dog. Thiopental concentrations in lymph were significantly higher than phenobarbital concentrations for 30 min after drug administration. Disparity between portal plasma and lymph concentrations for thiopental during the first 15 min was about 1/3 as great as the same difference for phenobarbital. Thiopental displayed an average of twice the affinity for lipid (chylomicron) lymph as did phenobarbital. Because of its greater lipid solubility, thiopental is absorbed more by lymph than is phenobarbital. Both barbiturates are absorbed more quantitatively by the portal rather than lymphatic circulation, probably due to variation in the rate of flow of these 2 systems.
Assuntos
Sistema Linfático/metabolismo , Fenobarbital/farmacocinética , Tiopental/farmacocinética , Anestesia , Animais , Biotransformação , Quilomícrons/metabolismo , Cães , Feminino , Concentração de Íons de Hidrogênio , Metabolismo dos Lipídeos , Fenobarbital/sangue , Veia Porta/metabolismo , Tiopental/sangueRESUMO
Patients with significant cardiac sarcoidosis are at increased risk of sudden death from ventricular dysrhythmias or conduction disturbances. We report two patients whose initial manifestation of cardiac sarcoidosis was nonsustained ventricular tachycardia unresponsive to standard antiarrhythmic measures. Endomyocardial biopsy aided the diagnosis in each patient. This technique is helpful in establishing the diagnosis of cardiac sarcoidosis, which causes life-threatening ventricular dysrhythmias.
