[A case-control study on the quality of life and the way of response among patients with anxiety disorder in Shandong province].

OBJECTIVE: To explore the characteristics related to the quality of life and the way of response among patients with anxiety disorder in Shandong province. METHODS: Case-control study was adopted, with secondary data analysis on mental disorders among adults over 18 years of age, in Shandong province. 720 patients with anxiety disorder who met the anxiety diagnostic criteria of DSM-IV, were selected from the database, according to the distributions on gender, age (±3 years of age), village or community. 720 persons without any psychiatric diagnosis were selected and served as controls, under 1 :1 paired choice. Research tools would include:General Health Questionnaire (GHQ-12),Quality of Life Questionnaire (QLQ), Simplified Coping Style Questionnaire (SCSQ), and questionnaire on general information. RESULTS: Scores of QLQ among patients with anxiety disorder were lower than that of the control group, with statistically significant difference(P < 0.01). Scores on the negative ways of coping among patients with anxiety disorder were higher than the scores of the control group, with statistically significant difference(P < 0.01). Regardless of gender, age, occupation, education, marriage, religious belief etc., results from the 'two factors anova-analysis' showed that the scores of QLQ among patients with anxiety disorder were still lower than the scores of the control group while the scores on negative coping were still higher than the scores of the control group. CONCLUSION: Patients with anxiety disorder and having poor quality of life outnumbered the ones from the control group, and using negative coping ways to cope with the stress events.

[Dispersion behavior of effective ingredients in Chinese medicine decoctions].

OBJECTIVE: To research the disperse behavior of many Chinese medicine decoctions. METHODS: Through the analysis of the dispersible attributes of 22 kinds of Chinese medicine decoctions including Radix Salviae Miltiorrhizae by means of turbidity, ultramicroscope and TEM, we found that a lot of nanometer particles existed in these decoctions after 4000 r/min centrifugation. Based on the model of Radix Salviae Miltiorrhizae, we analyzed the influence on the loss of effective ingredients by way of centrifugation, alcohol precipitation, flocculation and salting-out edulcoration. RESULTS: The removal of infinite nanometer particles from these decoctions led to the greater loss of water-soluble and fat-soluble ingredients,and the latter accounts for the major loss. CONCLUSION: Oral liquid preparation of traditional Chinese medicine is a kind of nano-pharmaceutics with nanometer particles dispersed in the water as the carriers of effective ingredients in medicine.

[The pathway of absorption and conveying of puerarin microemulsion-in-oil].

The best absorption location of puerarin microemulsion-in-oil in intestine parva of rat and pharmacokinetic characteristics, and the pathway of absorption and conveying of puerarin microemulsion were studied. In situ rat perfusion method was used to investigate the intestinal absorption of puerarin. Through the changes of drug concentration in blocked and unblocked lymphs, to determine the pathway of absorption and conveying. Puerarin microemulsion-in-oil can be absorbed in any part of intestine, and the K(a), P(app) of every part is ileum > duodenum > jejunum > colon, and the K(a), P(app) of ileum is significantly larger than that of others. The absorption rate of different concentrations is not significantly different (P > 0.05). The puerarin transited by gastrointestinal tract, about 36.8% is absorbed by the lymphatic channels to enter the systemic circulation and 63.2% is absorbed by the non-lymphatic channels. The best part of intestine to absorb puerarin microemulsion is ileum, and it is passive transport. The pathway of conveying is lymphoid and non-lymphoid transit.

[Synthesis and antitumor activities of triazacyclodecane and its platinum (II) complex].

To search for potential antitumor drugs with potent efficiency and low toxicity, a novel 1,4,7-triazacyclodecane and its platinum (II) complex were synthesized. These compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, MS spectra, thermoanalysis and conductivity measurement. Antitumor activity study indicated these compounds had strong antitumor activity in vitro to some extent. Inhibition of human liver tumor of CA was examined by antitumor rate and growth rate, complex C showed inhibition activity on transplanting-tumor growth of CA, 12 mg x kg(-1) was as potent as cisplatin, its ID50 was 853.6 mg x kg(-1).