An improved NFC device authentication protocol.

Aimed at the security authentication problem between Near Field Communication (NFC) devices, this paper uses the technology of asymmetric encryption algorithm, symmetric encryption algorithm, hash function, timestamp and survival period to improve the confidentiality, performance and security of the protocol. The symmetric encryption algorithm encrypts the transmission content, while the asymmetric encryption algorithm encrypts the shared key. The whole authentication process is secure, and the key distribution is secure. The improved NFC device authentication protocol can effectively resist the brute force attack, man-in-the-middle attack and replay attack in the authentication process, it can reduce the number of message transmission in the authentication process, improve the transmission efficiency, enhance the confidentiality, integrity, non-repudiation and improve the security of NFC device authentication.

Novel indoline-1- or 3,4-dihydroquinoline-1(2H)-substituted carbothiohydrazides as TPO receptor agonists.

Synthesis and evaluation of novel series of indoline-1- or 3,4-dihydroquinoline-1(2H)-substituted carbothiohydrazide or carbohydrazide based small molecule compounds as thrombopoietin (TPO) receptor agonists are reported. Members of these compounds have been identified as full agonists of human c-mpl in BaF3/TPOR cell line. Indoline-1-carbohydrazide 9b exhibited reasonable pharmacokinetic profile.

Synthesis and biological evaluation of oxoindolin-3-ylidene ethyl benzothiohydrazides as non-peptide TPO mimics.

A novel series of oxoindolin-3-ylidene ethyl benzohydrazides were designed, synthesized, and identified as small molecule agonists of thrombopoietin (TPO) receptor c-mpl. Sulfur-oxygen exchange in oxoindolin-3-ylidene ethyl benzohydrazides was found to improve their agonistic activities. Several oxoindolin-3-ylidene ethyl benzothiohydrazides have been identified as full agonists of c-mpl.