The Role of Resveratrol on Spinal Cord Injury: from Bench to Bedside.

Spinal cord injury (SCI) is a severe and disabling injury of the central nervous system, with complex pathological mechanisms leading to sensory and motor dysfunction. Pathological processes, such as oxidative stress, inflammatory response, apoptosis, and glial scarring are important factors that aggravate SCI. Therefore, the inhibition of these pathological processes may contribute to the treatment of SCI. Currently, the pathogenesis of SCI remains under investigation as SCI treatment has not progressed considerably. Resveratrol, a natural polyphenol with anti-inflammatory and antioxidant properties, is considered a potential therapeutic drug for various diseases and plays a beneficial role in nerve damage. Preclinical studies have confirmed that signaling pathways are closely related to the pathological processes in SCI, and resveratrol is believed to exert therapeutic effects in SCI by activating the related signaling pathways. Based on current research on the pathways of resveratrol and its role in SCI, resveratrol may be a potentially effective treatment for SCI. This review summarizes the role of resveratrol in promoting the recovery of nerve function by regulating oxidative stress, inflammation, apoptosis, and glial scar formation in SCI through various mechanisms and pathways, as well as the deficiency of resveratrol in SCI research and the current and anticipated research trends of resveratrol. In addition, this review provides a background for further studies on the molecular mechanisms of SCI and the development of potential therapeutic agents. This information could also help clinicians understand the known mechanisms of action of resveratrol and provide better treatment options for patients with SCI.

A low-frequency normal conducting cavity with higher-order mode damping for fourth-generation synchrotron radiation sources.

The utilization of a low-frequency (<200 MHz) RF system in storage facilitates the attainment of ultra-low emittances in synchrotron light sources through on-axis injection. This paper focuses on the development of a low-frequency normal conducting (NC) cavity with higher-order mode (HOM) damping for fourth-generation synchrotron light sources. We propose a novel approach to achieve efficient HOM damping in a NC cavity by optimizing the lowest frequency HOM and implementing a beam-line absorber. Notably, unlike conventional NC cavities, the presence of a large beam tube for the beam-line absorber does not compromise the accelerating performance in a coaxial resonant cavity, enabling effective HOM damping while maintaining a high shunt impedance. Through simulations, the prototype design of a 166.6 MHz HOM-damped cavity demonstrates a fundamental mode impedance of ∼8 MΩ, with longitudinal and transverse HOM impedances below 2.0 and 50 kΩ/m, respectively.

Bullet migration from the knee to the heart after a gunshot injury: a case report.

Migration of a bullet to a distant part of the body after a gunshot is rarely observed in the clinical setting, and migration to the heart is even rarer. There are usually no clear symptoms or signs from migration of a bullet. The bullet can be easily missed and sometimes identified in a review examination. A case of bullet migration to the heart 2 months after a gunshot to the left knee was reported.

[Synthesis and photoluminescence of novel terbium(III) ternary complexes with carboxylic acid].

In the present paper, imidazo[5,6-f] phenanthroline(IP), 2-aniline carbonyl benzoic acid (HAB) and 2-diphenylamine carbonyl benzoic acid (HDPAB) were synthesized at room temperature. Under the same condition, with HAB and HDPAB as the first ligand and IP as the secondary ligand, two novel ternary organic terbium complexes were prepared in ethanol solution. Elemental analysis demonstrated that the chemical formula of the two ternary complexes were Tb(HAB)3IP and Tb(HDPAB)3IP. The spectroscopic properties of the ligands and complexes were also discussed. IR spectra indicated that rare earth Tb3+ ion was coordinated with oxygen atoms of the first ligand HAB and HDPAB and two nitrogen atoms of the secondary ligand IP. The UV spectra showed that the main absorption was from the first ligand in the ternary complexes, the secondary ligand was bonded to rare earth Tb3+ ion and the energy transfer efficiency of HAB was higher than that of HDPAB. The excitation and emission spectra of the two terbium complexes were measured and investigated, especially by comparing their fluorescence intensities. Fluorescence spectra demonstrated that the two kinds of ternary organic terbium complexes could emit characteristic fluorescence of rare earth Tb3+ ion. But the fluorescence intensity of Tb(HAB) IP was obviously higher than that of Tb(HDPAB)3 IP. Compared with two first ligands HDPAB and HAB, the fluorescence intensities of the two ternary organic terbium complexes were found to be influenced by the molecule structure, and the benzene ring which was coordinated with nitrogen atom increased in HDPAB. In the system of ternary complexes, due to the different coordinated number of benzene ring, the mobility of electron and the distribution of electron cloud were changed. The variation affected the transition of the pi electrons, which can take in the energy in ternary complexes. So, the energy transfer efficiency from the first ligand to rare earth Tb3+ ion decreased and Antenna effect achieved inefficiency in Tb(HDPAB)3IP.