[Effect of alpha-lipoic acid preparations on bilirubin and transferrin levels and ferritin iron and transferrin iron content]. / Vplyv preparativ alpha-lipoievoï kysloty na riven' bilirubinu, transferinu ta vmist azliza u skladi ferytinu i transferynu.

The influence of ethylendiamine salt of alpha-lipoic acid on the indices of iron metabolism in patients with occupational pathologies has been studied using quantitative electron spin resonance spectroscopy. In the cases of treatment in the patients suffering from hyperferremia the decrease in transferrin iron concentration in the whole blood and plasma occurs correlating with the enhancement of iron excretion from urine and decline of bilirubin level in serum. We have found that the preparation chelates iron from iron (III)-citrate complex and form stable iron (III) complexes. The conclusion is that the positive effects of lipoic acid preparation in the patients with hyperferremia at least partially could be associated with normalization of iron exchange and reduction in the labile iron pool.

[Berlition R 300 oral -- alpha-lipoic acid preparation for the correction of body changes associated with high serum iron content]. / Preparat alfa-lipoevoi kisloty berlition R 300 oral' kak sredstvo korrektsii izmenenii v organizme, sviazannykh s giperferremiei.

Medication Berlition 300 oral, produced by "Berlin-Hemie", induces lower serum iron content, decrease in transferrin content of whole blood and serum proportionally to increased urinary iron excretion and lower serum bilirubin and normalizes serum glucose level. Berlition 300 oral, lipoic acid preparation made by "Berlin-He mie" (Menarini group), could be recommended for treatment of high serum iron content and iron overload, especially in association with diabetes mellitus.

[Classification of pneumoconiosis]. / O klassifikatsii pnevmokonioza.

The article presents a modern classification of pneumoconiosis taking account of the international classification and experience gained by specialists in this country.

[The results of a clinical study of the preparation Fastum gel in patients with certain forms of occupational diseases]. / Rezul'taty klinicheskogo issledovaniia preparata Fastum gel' u bol'nykh s nekotorymi formami professional'nykh zabolevanii.

The article presents a positive appraisal of efficacy of local application of the drug Fastum-gel (ketoprophen) in a combined treatment of occupational diseases of the locomotor and neuromuscular apparatus. A maximum therapeutic effect was noted in treatment of patients with above medical problems.

[Lipid metabolism, iron metabolic indices and the rates of aging in welders with occupational diseases of the respiratory organs]. / Lipidnyi obmen, pokazateli obmena zheleza i tempy stareniia u svarshchikov s professional'nymi zabolevaniiami organov dykhaniia.

A study was made of relationship between biologic age of welders and their health status. The results obtained suggest that evolution of occupational abnormalities of bronchipulmonary system may accelerate the welders' rate of aging two-fold. Accumulation of iron in the organism of welders furthers the process of ageing as well. A high specific weight of patients with critically low level of the blood serum content of cholesterol (3.34 mmol/l) was found to be the case among welders with occupational abnormalities of bronchipulmonary system, which fact suggests a high risk for the pulmonary cancer development.

[The carcinogenic risk factor in the job of a steel welder]. / O faktore kantserogennogo riska v professii svarshchika stali.

The paper presents results of evaluation of carcinogenic risk in welders with due emphasis to sensibilization to organ-specific tumorous antigen of the lung determined by a test for electrophoretic mobility of indicator cells. Relationship was found between frequency and markedness of sensibilization and blood serum content of iron. It is suggested that carcinogenic risk in the occupation of the welder might be associated with both exposure to chromium, nickel, asbestos endowed with blastomogenic properties, and an increase accumulation of iron in the organism.

[The effect of the working conditions on the development of diseases in cast-iron welders]. / Vliianie uslovii truda na razvitie zabolevanii u svarshchikov chuguna.

It was established that during cast-iron welding unfavourable factors of this production are welding aerosols, thermal and physical loads, radiation of the optical range. Results of detailed medical screening evidence that 80% of cast-iron welders showed pathology of the internal organs. Diseases of the bronchopulmonary apparatus occupy the leading place and are registered in every second cast-iron welder. The incidence rises with increased length of work and age.

[Manifestations of excessive iron accumulation in steel and cast iron welders]. / Osobennosti proiavlenii peregruzki organizma zhelezom u svarshchikov stalei i chuguna.

Welding of steel and cast iron leads to overaccumulation of iron in the welder's organism, which manifests itself in the iron content growth in the whole blood and serum, an increase of serum general iron binding ability, calcium homeostasis disorders, decrease of cardiac muscle contraction, progressing pneumoconiosis with concomitant characteristic pneumohemosiderosis features. The secondary preventive measures of the occupational pathology should include a set of drugs and preparations to improve the iron content in the organism and related metabolic disorders.

[Reaction of the body to carbon oxide and iron compound in the composition of welding aerosol]. / Reaktsiia organizma na oksid ugleroda i soedineniia zheleza v sostave svarochnogo aérozolia.

Combined action of carbon oxide and iron, when inhaled as welding aerosol components, did not exhibit an adequate HbCO formation in the blood as a result of the protecting action of serous iron which reached the content level leading to the overload of the organism with iron.