Development of Novel Composite Biocompatible Materials by Surface Modification of Porous Inorganic Compounds Using Bambus[6]Uril.

In this present investigation, a novel series of composite materials based on porous inorganic compounds-hydroxyapatite and diatomite-have been innovatively formulated for the first time through surface modification employing the promising macromolecular compound, bambus[6]uril. The process entailed the application of a bambus[6]uril dispersion in water onto the surfaces of hydroxyapatite and diatomite. Extensive characterization was carried out, involving IR spectroscopy and SEM. The materials underwent assessment for hemolytic effects and plasma protein adsorption. The results revealed that materials containing surface-bound bambus[6]uril did not demonstrate inherent hemolytic effects, laying a robust groundwork for their use as biocompatible materials. These findings hold significant promise as an alternative pathway for the development of durable and efficient bio-composites, potentially unveiling supramolecular strategies incorporating encapsulated bambus[6]urils in analogous processes.

Nanoparticles Based on Silver Chloride and Bambusuril[6] for the Fine-Tuning of Biological Activity.

The prevalence of numerous infectious diseases has emerged as a grave concern within the realm of healthcare. Currently, the issue of antibiotic resistance is compelling scientists to explore novel treatment approaches. To combat these infectious diseases, various treatment methods have been developed, harnessing cutting-edge disinfecting nanomaterials. Among the range of metallic nanoparticles employed in medicine, silver nanoparticles (AgNPs) stand out as both highly popular and well-suited for the task. They find extensive utility in cancer diagnosis and therapies and as effective antibacterial agents. The interaction between silver and bacterial cells induces significant structural and morphological alterations, ultimately leading to cell demise. In this study, nanoparticles based on silver and bambusuril[6] (BU[6]) were developed for the first time. These NPs can be used for different biomedical purposes. A simple, single-step, and effective synthesis method was employed to produce bambusuril[6]-protected silver chloride nanoparticles (BU[6]-Ag/AgCl NPs) through the complexation of BU[6] with silver nitrate. The NPs were characterized using X-ray phase analysis (XPS), infrared spectroscopy (IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). When the SEM images were examined, it was seen that the synthesized BU[6]-Ag/AgCl NPs were distributed with homogeneous sizes, and the synthesized NPs were mostly spherical and cubic. The EDS spectra of BU[6]-Ag/AgCl NPs demonstrated the presence of Ag, Cl, and all expected elements. BU[6]-Ag/AgCl NPs showed high antibacterial activity against both E. coli and S. aureus bacteria.

Functionalization of the Surface of Porous Nickel-Titanium Alloy with Macrocyclic Compounds.

For the first time, we performed functionalization of the surface of porous titanium nickelide alloys with bambusuril[6]-based macrocyclic compounds by different methods in order to provide the basis for saturation with therapeutic agents to impart antibacterial activity and accelerate its osteogenesis. It has been shown for the first time that the vacuum modification method is preferable for bambusuril deposition, since it provides a uniform deposition of organic matter on both the outer and inner surfaces of the pores. The effect of bambusuril deposition methods on the continuity, structure, and cytocompatibility of the porous titanium nickelide surface was evaluated. In vitro tests proved high biocompatibility and low toxicity of porous TiNi treated with BU[6] under vacuum. The SEM study of the structure of the surface layer of TiNi modified with BU[6] under the vacuum method showed that BU[6] agglomerates are uniformly deposited on the inner and outer surfaces of TiNi pores, which will provide an even saturation of BU[6] cavities with various pharmaceuticals, including antibiotics and inhibitors.