Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Ácidos Araquidônicos , Edema/induzido quimicamente , Animais , Ácido Araquidônico , Inibidores de Ciclo-Oxigenase , Relação Dose-Resposta a Droga , Inibidores de Lipoxigenase , Masculino , Camundongos , Camundongos Endogâmicos C3H , Camundongos Endogâmicos , Ratos , Ratos Endogâmicos , Especificidade da EspécieRESUMO
In two generations of a big family two men in each generation were struck with a vitreoretinal disease, which led to vitreous haemorrhage and were first was interpreted as Periphlebitis retinae (Eale's disease). Preretinal, perforated membranes containing vessels and a severe macular degeneration pointed to a vitreoretinal dystrophy. The uniform alteration of the ERG with reduction of the b-waves were striking in all four patients. Judging from the X-chromosomal pattern of transmission, from the juvenile vitreous haemorrhages and from the macular dysplasia with radial plication we seem to be dealing with a sexlinked juvenile retinoschisis, although at first microscopic examination the vitreous veils did not make us think of a retinoschisis.
