[Peptide bioregulator efficacy in the correction of reduced thyroid gland function in the residents of Magadan Region].

Thyroid gland pathology is one of the most widespread diseases. Age is the main risk factor in the development of hypothyroid states, alongside with biogeochemical and climatic adverse factors of the environment. Disturbed hormonal status of the organism affects the quality of life in patients with subclinical and manifested hypothyroidism forms, especially in old age, and requires adequate correction methods. In this connection Thyramin bioregulator is noteworthy, exerting tissue specific effect on thyroid gland cells and enabling the restoration of the disturbed thyroid tissue function.

[Age-dependent reconstruction of element status in Magadan inhabitants]. / Vozrastnye perestroi élementnogo statusa zhitelei Magadana.

On the base of macro- and microelements' concentration in hair of Magadan's inhabitants there were analyzed the changes of aged people's element status. It has been shown that with age, differently directed reconstruction happened, leading to accumulation of one elements and decrease of concentration of others in inhabitants' hair. Elements, undergoing natural age reconstruction, may be considered as indicators and initiators of aging. We have allocated two groups of elements, in dependence on changes' direction. The first group is the main one; Na, K, Ca, Se, As, Mg, Mn, Fe, Zn belong to this group; their level in hair is increasing with age. Taking into account the excretory function of hair, accumulation of named elements is considered as aged removing of these elements out of organism. The exception is the toxic As: its superfluous concentrations in hair reflect the accumulation As in the internal environment of organism. Elements (Cr, Si), concentration of which in hair is decreasing with age, belong to the second group. On the base of literary data, the decreasing of named elements in hair must be interpreted as their programmed decreasing in the organism of aged people. Hence, in aged people there is seen the generalized decreasing of the most studied essential macro- and microelements in the organism. The exception is As, concentration of which is increasing in aged people. The age disorder of element homeostasis may serve as a predictor of "normal" diseases and may be one of pathophysiological mechanisms of aging.

[Features of tissue differentiation of the thyroid gland in residents of Magadan]. / Osobennosti tkanevoi differentsirovki shchitovidnoi zhelezy u zhitelei Magadana.

The histological structure and morphometric parameters of the thyroid gland were examined in fetuses, newborns and infants during the early postnatal period to assess the peculiarities of thyroid differentiation in Magadan goiter endemic region. It was demonstrated that fetal thyroid gland remained immature. Functional strain of thyroid structures was shown in neonatal period that is considered to be the manifestation of the adaptive responses of the newborn. In infants aged 2-3 months thyroid gland attained definitive morphometric parameters that indicated its functional maturity. Low rate of tissue differentiation in the thyroid gland during prenatal period may result from iodine deficiency in both mother and fetus, which is aggravated by the unfavorable natural climatic factors of the North.