RESUMO
Biochemical and morphometric analyses have been made of the effects of nonapeptide neurohormones, vasotocin and mesotocin, on the chromaffin tissue of the adrenal gland of the frog, both in vivo and in vitro experiments. It was shown that vasotocin exerts stimulating effect on the suprarenal gland whereas mesotocin inhibits the latter. In vitro experiments revealed that adrenalin may abolish the effect of nonapeptides on the suprarenal gland.
Assuntos
Glândulas Suprarrenais/efeitos dos fármacos , Ocitocina/análogos & derivados , Vasotocina/farmacologia , Glândulas Suprarrenais/anatomia & histologia , Glândulas Suprarrenais/metabolismo , Animais , Cosintropina/farmacologia , Relação Dose-Resposta a Droga , Interações Medicamentosas , Epinefrina/farmacologia , Técnicas In Vitro , Masculino , Ocitocina/farmacologia , Rana temporariaRESUMO
Morphometric studies indicate that vasotocin increases the activity of the adrenal gland in frogs, whereas mesotocin and epinephrine do not essentially affect it. Combination of epinephrine with nonapeptides in cultural medium showed that the former may abolish the effect of vasotocin on the adrenal gland.
Assuntos
Epinefrina/farmacologia , Glândula Inter-Renal/efeitos dos fármacos , Ocitocina/análogos & derivados , Vasotocina/farmacologia , Animais , Cosintropina/farmacologia , Relação Dose-Resposta a Droga , Técnicas In Vitro , Glândula Inter-Renal/citologia , Masculino , Ocitocina/farmacologia , Rana temporariaRESUMO
Morphometric and biochemical studies have been made on the activity of interrenal gland in the frog Rana temporaria after removal of the anterior lobe of pituitary and injections of arginine vasotocin and mesotocin. It was demonstrated that the activity of this gland after the operation decreases increasing after arginine vasotocin injections.