[Therapy-resistant aggressive cystic lesion of the mandible]. / Therapieresistente aggressive zystische Läsion des Unterkiefers.

Several extensive surgical interventions of a cystic lesion in the left mandible were followed by recurrences. The lesion extended from the primary mandibular region into the area of pterygopalatine fossa finally infiltrating the orbital region and the skull base. Histological results could never demonstrate a malignancy with certainty. Due to the patient's poor general condition, the refusal for further surgical inventions and due to the malignoma-like growth pattern radiation treatment was performed. However, this had no effect on tumor progression.

Physical exercise results in the improved subjective well-being of a few or is effective rehabilitation for all cancer patients?

Physical exercise as an intervention in cancer patients has attracted increasing interest. This review examines the published randomised controlled trials on physical exercise, during and after cancer treatment, focusing primarily on recruitment of patients, patient compliance, content of the intervention programmes and outcome measures. We performed systematic searches of PubMed, PsychInfo, Cancerlit and the Cochrane Library using the MESH terms exercise, neoplasms, cancer, rehabilitation and intervention. We identified 12 randomised trials with sample sizes ranging from 21 to 155 patients. Only four studies reported the number of patients assessed for eligibility and the reasons for exclusion; 15% to 30% of patients assessed for eligibility were randomised into the intervention programmes. Drop-out rates in the trials ranged from 0% to 34%. Most studies included female breast cancer patients (nine studies, 62% of total number of patients). Interventions included aerobic exercise training (10 studies) and resistance exercise (two studies). The studies used a wide range of instruments to assess health-related quality of life (HRQOL) and the physical exercise capacity. The studies indicated promising effects on both physiological and psychological outcomes. Randomised clinical studies are few, small in scope, and mainly focus on breast cancer patients. Complete knowledge about the type of physical exercise most beneficial for patients at different stages of the disease progression is still lacking. Future work should identify fewer and more specific endpoints.

[Bladder tumor, metastasis from breast carcinoma. A case report with literature review]. / Blaeretumor, metastase fra mammakarsinom. En kasuistikk med litteraturoversikt.

Breast cancer is the most common type of cancer amongst. Norwegian women. It spreads to various localisations, the most usual foci being lymphatic nodes, lungs, liver and bone. For a long time, metastatic breast cancer to the urinary bladder has been considered an extremely rare manifestation. We describe one case in which metastasis to the bladder from breast cancer caused clinically important symptoms. We discuss the pathophysiology, symptoms and diagnostic tools in regard to this rare phenomenon, and why bladder metastasis from breast cancer has become, and will continue to become increasingly important.

Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis.

In a controlled, double blind, clinical trial we tested the effect of dietary omega-3 fatty acid supplementation with and without naproxen and placebo, respectively, in 67 patients with active rheumatoid arthritis. The patients were randomized into 3 groups that received the following treatment: Group 1, corn oil ("placebo omega-3 fatty acids"), 7 g/day for 16 weeks, and naproxen, 750 mg/day for 10 weeks followed by a stepwise reduction to 0 mg/day during the following 3 weeks; Group 2, omega-3 fatty acids, 3.8 g of eicosapentaenoic acid plus 2.0 g of docosahexaenoic acid, and naproxen, 750 mg/day for 16 weeks; and Group 3, omega-3 fatty acids as Group 2 and naproxen as Group 1. At the end of the trial, patients in Group 2 had improved with respect to duration of morning stiffness and global assessment by physician and patient. In Groups 1 and 3 there was a significant deterioration for most of the variables measured. However, for duration of morning stiffness the deterioration was significantly less pronounced in Group 3 compared with Group 1. These effects might be ascribed to the dietary omega-3 fatty acid supplementation.

Effect of PEEP-valve placement on function of a home-care ventilator.

BACKGROUND: The addition of a PEEP valve to the circuit of a home-care ventilator like the Aequitron LP-6 can be viewed as a consumer modification of the system. We sought to determine the effect that such a modification would have on ventilator function. METHODS & MATERIALS: Part 1. We tested the effect of PEEP level and PEEP-valve position on volume delivered at the ventilator Y-adapter, over a range of tidal volumes. Part 2. We held tidal volume, frequency, and inspiratory time constant, and varied PEEP level and PEEP-valve position to test the effect of PEEP-valve position on pressures measured at the ventilator outlet, patient-Y, and within the exhalation-valve pressurization line. RESULTS: Conventional placement of the PEEP value (distal to, or 'after,' the exhalation valve) in the LP-6 ventilator circuit resulted in statistically significant and potentially clinically important decreases in the volumes delivered to the patient at some ventilator settings. Proximal placement of the PEEP valve (proximal to, or 'before,' the exhalation valve) resulted in consistent volumes delivered to the patient at all levels tested, without changing the ventilatory performance characteristics of the ventilator as reflected by pressure waveforms. CONCLUSION: We recommend that appropriate observations and measurements be made to verify system function before a home-care ventilator modified to provide PEEP is applied to the patient.