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Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction.
Obstet Gynecol
; 119(2 Pt 2): 452-455, 2012 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22270436
RESUMO
BACKGROUND: Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity. CASE: A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate. CONCLUSION: Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility.