[Soft tissue reaction following bioactive and bio-inactive implantation materials in subcutaneous tissue of rats]. / Zur Weichgewebsreaktion nach Implantation bioaktiver und bioinaktiver Implantatmaterialien im Subkutangewebe der Ratte.

The investigation of bioactive materials in the subcutaneous tissue of the rat is a method of the biocompatibility testing of newly developed bio-vitrokerame. The histological assessment of the course of wound healing was the base of the evaluation after a period of 40 days. An extensively concluded cellular reaction and the formation of a thin fibrous capsule can be judged positively with aluminium oxide ceramics and beta tricalcium phosphate. Bioactive materials of a determined combination can arise problems.

[Immunosuppressive long-term treatment of chronic aggressive hepatitis]. / Immunosuppressive Langzeitherapie der chronisch aggressiven Hepatitis

47 patients with chronic aggressive hepatitis were immunosuppressively treated on the average 33.8 months (daily dose 100 mg azathioprine and 10 mg prednisolone). The serochemical parameters thymol, ZnSO4, GOT and GPT statistically significantly improved themselves. In 36 patients bioptic controls in 61.1% resulted in an improvement, and in 27.8% of the cases they resulted in a constancy of the histological findings. 10.6% of the patients died of a liver cirrhosis with portal hypertension. Nearly half the patients is capable to work. No severe side-effects appeared. The present results correspond to the results mentioned in literature. The chronic aggressive hepatitis, furthermore, should be added to a prednisone monotherapy or to a combination therapy of azathioprine and prednisone.