DiamondNet: A Neural-Network-Based Heterogeneous Sensor Attentive Fusion for Human Activity Recognition.

With the proliferation of intelligent sensors integrated into mobile devices, fine-grained human activity recognition (HAR) based on lightweight sensors has emerged as a useful tool for personalized applications. Although shallow and deep learning algorithms have been proposed for HAR problems in the past decades, these methods have limited capability to exploit semantic features from multiple sensor types. To address this limitation, we propose a novel HAR framework, DiamondNet, which can create heterogeneous multisensor modalities, denoise, extract, and fuse features from a fresh perspective. In DiamondNet, we leverage multiple 1-D convolutional denoising autoencoders (1-D-CDAEs) to extract robust encoder features. We further introduce an attention-based graph convolutional network to construct new heterogeneous multisensor modalities, which adaptively exploit the potential relationship between different sensors. Moreover, the proposed attentive fusion subnet, which jointly employs a global-attention mechanism and shallow features, effectively calibrates different-level features of multiple sensor modalities. This approach amplifies informative features and provides a comprehensive and robust perception for HAR. The efficacy of the DiamondNet framework is validated on three public datasets. The experimental results demonstrate that our proposed DiamondNet outperforms other state-of-the-art baselines, achieving remarkable and consistent accuracy improvements. Overall, our work introduces a new perspective on HAR, leveraging the power of multiple sensor modalities and attention mechanisms to significantly improve the performance.

ADST: Forecasting Metro Flow Using Attention-Based Deep Spatial-Temporal Networks with Multi-Task Learning.

Passenger flow prediction has drawn increasing attention in the deep learning research field due to its great importance in traffic management and public safety. The major challenge of this essential task lies in multiple spatiotemporal correlations that exhibit complex non-linear correlations. Although both the spatial and temporal perspectives have been considered in modeling, most existing works have ignored complex temporal correlations or underlying spatial similarity. In this paper, we identify the unique spatiotemporal correlation of urban metro flow, and propose an attention-based deep spatiotemporal network with multi-task learning (ADST-Net) at a citywide level to predict the future flow from historical observations. ADST-Net uses three independent channels with the same structure to model the recent, daily-periodic and weekly-periodic complicated spatiotemporal correlations, respectively. Specifically, each channel uses the framework of residual networks, the rectified block and the multi-scale convolutions to mine spatiotemporal correlations. The residual networks can effectively overcome the gradient vanishing problem. The rectified block adopts an attentional mechanism to automatically reweigh measurements at different time intervals, and the multi-scale convolutions are used to extract explicit spatial relationships. ADST-Net also introduces an external embedding mechanism to extract the influence of external factors on flow prediction, such as weather conditions. Furthermore, we enforce multi-task learning to utilize transition passenger flow volume prediction as an auxiliary task during the training process for generalization. Through this model, we can not only capture the steady trend, but also the sudden changes of passenger flow. Extensive experimental results on two real-world traffic flow datasets demonstrate the obvious improvement and superior performance of our proposed algorithm compared with state-of-the-art baselines.

Accurate and Robust Floor Positioning in Complex Indoor Environments.

With the widespread development of location-based services, the demand for accurate indoor positioning is getting more and more urgent. Floor positioning, as a prerequisite for indoor positioning in multi-story buildings, is particularly important. Though lots of work has been done on floor positioning, the existing studies on floor positioning in complex multi-story buildings with large hollow areas through multiple floors still cannot meet the application requirements because of low accuracy and robustness. To obtain accurate and robust floor estimation in complex multi-story buildings, we propose a novel floor positioning method, which combines the Wi-Fi based floor positioning (BWFP), the barometric pressure-based floor positioning (BPFP) with HMM and the XGBoost based user motion detection. Extensive experiments show that using our proposed method can achieve 99.2% accuracy, which outperforms other state-of-the-art floor estimation methods.

A Human Activity Recognition Algorithm Based on Stacking Denoising Autoencoder and LightGBM.

Recently, the demand for human activity recognition has become more and more urgent. It is widely used in indoor positioning, medical monitoring, safe driving, etc. Existing activity recognition approaches require either the location information of the sensors or the specific domain knowledge, which are expensive, intrusive, and inconvenient for pervasive implementation. In this paper, a human activity recognition algorithm based on SDAE (Stacking Denoising Autoencoder) and LightGBM (LGB) is proposed. The SDAE is adopted to sanitize the noise in raw sensor data and extract the most effective characteristic expression with unsupervised learning. The LGB reveals the inherent feature dependencies among categories for accurate human activity recognition. Extensive experiments are conducted on four datasets of distinct sensor combinations collected by different devices in three typical application scenarios, which are human moving modes, current static, and dynamic behaviors of users. The experimental results demonstrate that our proposed algorithm achieves an average accuracy of 95.99%, outperforming other comparative algorithms using XGBoost, CNN (Convolutional Neural Network), CNN + Statistical features, or single SDAE.

A Fast Indoor/Outdoor Transition Detection Algorithm Based on Machine Learning.

The widespread popularity of smartphones makes it possible to provide Location-Based Services (LBS) in a variety of complex scenarios. The location and contextual status, especially the Indoor/Outdoor switching, provides a direct indicator for seamless indoor and outdoor positioning and navigation. It is challenging to quickly detect indoor and outdoor transitions with high confidence due to a variety of signal variations in complex scenarios and the similarity of indoor and outdoor signal sources in the IO transition regions. In this paper, we consider the challenge of switching quickly in IO transition regions with high detection accuracy in complex scenarios. Towards this end, we analyze and extract spatial geometry distribution, time sequence and statistical features under different sliding windows from GNSS measurements in Android smartphones and present a novel IO detection method employing an ensemble model based on stacking and filtering the detection result by Hidden Markov Model. We evaluated our algorithm on four datasets. The results showed that our proposed algorithm was capable of identifying IO state with 99.11% accuracy in indoor and outdoor environment where we have collected data and 97.02% accuracy in new indoor and outdoor scenarios. Furthermore, in the scenario of indoor and outdoor transition where we have collected data, the recognition accuracy reaches 94.53% and the probability of switching delay within 3 s exceeds 80%. In the new scenario, the recognition accuracy reaches 92.80% and the probability of switching delay within 4 s exceeds 80%.

Pedestrian Stride-Length Estimation Based on LSTM and Denoising Autoencoders.

Accurate stride-length estimation is a fundamental component in numerous applications, such as pedestrian dead reckoning, gait analysis, and human activity recognition. The existing stride-length estimation algorithms work relatively well in cases of walking a straight line at normal speed, but their error overgrows in complex scenes. Inaccurate walking-distance estimation leads to huge accumulative positioning errors of pedestrian dead reckoning. This paper proposes TapeLine, an adaptive stride-length estimation algorithm that automatically estimates a pedestrian's stride-length and walking-distance using the low-cost inertial-sensor embedded in a smartphone. TapeLine consists of a Long Short-Term Memory module and Denoising Autoencoders that aim to sanitize the noise in raw inertial-sensor data. In addition to accelerometer and gyroscope readings during stride interval, extracted higher-level features based on excellent early studies were also fed to proposed network model for stride-length estimation. To train the model and evaluate its performance, we designed a platform to collect inertial-sensor measurements from a smartphone as training data, pedestrian step events, actual stride-length, and cumulative walking-distance from a foot-mounted inertial navigation system module as training labels at the same time. We conducted elaborate experiments to verify the performance of the proposed algorithm and compared it with the state-of-the-art SLE algorithms. The experimental results demonstrated that the proposed algorithm outperformed the existing methods and achieves good estimation accuracy, with a stride-length error rate of 4.63% and a walking-distance error rate of 1.43% using inertial-sensor embedded in smartphone without depending on any additional infrastructure or pre-collected database when a pedestrian is walking in both indoor and outdoor complex environments (stairs, spiral stairs, escalators and elevators) with natural motion patterns (fast walking, normal walking, slow walking, running, jumping).

An Infrastructure-Free Indoor Localization Algorithm for Smartphones.

Accurate indoor positioning technology provides location-based service for a variety of applications. However, most existing indoor localization approaches (e.g., Wi-Fi and Bluetooth-based methods) rely heavily on positioning infrastructure, which prevents their large-scale deployment and limits the range at which they are applicable. Here, we proposed an infrastructure-free indoor positioning and tracking approach, termed LiMag, which used ubiquitous magnetic field and ambient lights (e.g., fluorescent, incandescent, and light-emitting diodes (LEDs)) without containing modulated information. We conducted an in-depth study on both the advantages and the challenges in leveraging magnetic field and ambient light intensity for indoor localization. Based on the insights from this study, we established a hybrid observation model that took full advantage of both the magnetic field and ambient light signals. To address the low discernibility of the hybrid observation model, LiMag first generated a single-step fingerprint model by vectorizing consecutive hybrid observations within each step. In order to accurately track users, a lightweight single-step tracking algorithm based on the single-step fingerprints and the particle filter framework was designed. LiMag leveraged the walking information of users and several single-step fingerprints to generate long trajectory fingerprints that exhibited much higher location differentiation ability than the single-step fingerprint. To accelerate particle convergence and eliminate the accumulative error of single-step tracking algorithm, a long trajectory calibration scheme based on long trajectory fingerprints was also introduced. An undirected weighted graph model was constructed to decrease the computational overhead resulting from this long trajectory matching. In addition to typical indoor scenarios including offices, shopping malls and parking lots, we also conducted experiments in more challenging scenarios, including large open-plan areas as well as environments characterized by strong sunlight. Our proposed algorithm achieved a 75th percentile localization accuracy of 1.8 m and 2.2 m, respectively, in the office and shopping mall tested. In conclusion, our LiMag algorithm provided location-based service of infrastructure-free with significantly improved localization accuracy and coverage, as well as satisfactory robustness inside complex indoor environments.

Silencing MR-1 attenuates atherosclerosis in ApoE-/- mice induced by angiotensin II through FAK-Akt-mTOR-NF-kappaB signaling pathway.

Myofibrillogenesis regulator-1 (MR-1) is a novel protein involved in cellular proliferation, migration, inflammatory reaction and signal transduction. However, little information is available on the relationship between MR-1 expression and the progression of atherosclerosis. Here we report atheroprotective effects of silencing MR-1 in a model of Ang II-accelerated atherosclerosis, characterized by suppression focal adhesion kinase (FAK) and nuclear factor kappaB (NF-κB) signaling pathway, and atherosclerotic lesion macrophage content. In this model, administration of the siRNA-MR-1 substantially attenuated Ang II-accelerated atherosclerosis with stabilization of atherosclerotic plaques and inhibited FAK, Akt, mammalian target of rapamycin (mTOR) and NF-kB activation, which was associated with suppression of inflammatory factor and atherogenic gene expression in the artery. In vitro studies demonstrated similar changes in Ang II-treated vascular smooth muscle cells (VSMCs) and macrophages: siRNA-MR-1 inhibited the expression levels of proinflammatory factor. These studies uncover crucial proinflammatory mechanisms of Ang II and highlight actions of silencing MR-1 to inhibit Ang II signaling, which is atheroprotective.

Constructing an Indoor Floor Plan Using Crowdsourcing Based on Magnetic Fingerprinting.

A large number of indoor positioning systems have recently been developed to cater for various location-based services. Indoor maps are a prerequisite of such indoor positioning systems; however, indoor maps are currently non-existent for most indoor environments. Construction of an indoor map by external experts excludes quick deployment and prevents widespread utilization of indoor localization systems. Here, we propose an algorithm for the automatic construction of an indoor floor plan, together with a magnetic fingerprint map of unmapped buildings using crowdsourced smartphone data. For floor plan construction, our system combines the use of dead reckoning technology, an observation model with geomagnetic signals, and trajectory fusion based on an affinity propagation algorithm. To obtain the indoor paths, the magnetic trajectory data obtained through crowdsourcing were first clustered using dynamic time warping similarity criteria. The trajectories were inferred from odometry tracing, and those belonging to the same cluster in the magnetic trajectory domain were then fused. Fusing these data effectively eliminates the inherent tracking errors originating from noisy sensors; as a result, we obtained highly accurate indoor paths. One advantage of our system is that no additional hardware such as a laser rangefinder or wheel encoder is required. Experimental results demonstrate that our proposed algorithm successfully constructs indoor floor plans with 0.48 m accuracy, which could benefit location-based services which lack indoor maps.

Jingzhaotoxin-II, a novel tarantula toxin preferentially targets rat cardiac sodium channel.

Naturally occurring toxins are invaluable tools for exploration of the structure and function relationships of voltage-gated sodium channels (VGSCs). In this study, we isolated and characterized a novel VGSC toxin named jingzhaotoxin-II (JZTX-II) from the tarantula Chilobrachys jingzhao venom. JZTX-II consists of 32 amino acid residues including two acidic and two basic residues. Cloned and sequenced using 3'- and 5'-rapid amplification of the cDNA ends, the full-length cDNA for JZTX-II was found to encode a 63-residue precursor which contained a signal peptide of 21 residues, a propeptide of 10 residues and a mature peptide of 32 residues. Under whole-cell voltage-clamp conditions, JZTX-II significantly slowed rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC50=0.26+/-0.09 microM. In addition, JZTX-II had no effect on TTX-R VGSCs on rat dorsal root ganglion neurons but exerted a concentration-dependent reduction in tetrodotoxin-sensitive (TTX-S) VGSCs accompanied by a slowing of sodium current inactivation similar to delta-ACTXs. It is notable that TTX-S VGSCs on cultured rat hippocampal neurons were resistant to JZTX-II at high dose. Based on its high selectivity for mammalian VGSC subtypes, JZTX-II might be an important ligand for discrimination of VGSC subtypes and for exploration of the distribution and modulation mechanisms of VGSCs.