Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources.

BACKGROUND: Ancient northern East Asians (ANEA) from the Yellow River region, who pioneered millet cultivation, play a crucial role in understanding the origins of ethnolinguistically diverse populations in modern China and the entire landscape of deep genetic structure and variation discovery in modern East Asians. However, the direct links between ANEA and geographically proximate modern populations, as well as the biological adaptive processes involved, remain poorly understood. RESULTS: Here, we generated genome-wide SNP data for 264 individuals from geographically different Han populations in Shandong. An integrated genomic resource encompassing both modern and ancient East Asians was compiled to examine fine-scale population admixture scenarios and adaptive traits. The reconstruction of demographic history and hierarchical clustering patterns revealed that individuals from the Shandong Peninsula share a close genetic affinity with ANEA, indicating long-term genetic continuity and mobility in the lower Yellow River basin since the early Neolithic period. Biological adaptive signatures, including those related to immune and metabolic pathways, were identified through analyses of haplotype homozygosity and allele frequency spectra. These signatures are linked to complex traits such as height and body mass index, which may be associated with adaptations to cold environments, dietary practices, and pathogen exposure. Additionally, allele frequency trajectories over time and a haplotype network of two highly differentiated genes, ABCC11 and SLC10A1, were delineated. These genes, which are associated with axillary odor and bilirubin metabolism, respectively, illustrate how local adaptations can influence the diversification of traits in East Asians. CONCLUSIONS: Our findings provide a comprehensive genomic dataset that elucidates the fine-scale genetic history and evolutionary trajectory of natural selection signals and disease susceptibility in Han Chinese populations. This study serves as a paradigm for integrating spatiotemporally diverse ancient genomes in the era of population genomic medicine.

Spatiotemporal characteristics and influencing factors of carbon emissions from land-use change in Shaanxi Province, China.

Due to global warming, there evolves a global consensus and urgent need on carbon emission mitigations, especially in developing countries. We investigated the spatiotemporal characteristics of carbon emissions induced by land use change in Shaanxi at the city level, from 2000 to 2020, by combining direct and indirect emission calculation methods with correction coefficients. In addition, we evaluated the impact of 10 different factors through the geodetector model and their spatial heterogeneity with the geographic weighted regression (GWR) model. Our results showed that the carbon emissions and carbon intensity of Shaanxi had increased overall in the study period but with a decreased growth rate during each 5-year period: 2000-2005, 2005-2010, 2010-2015, and 2015-2020. In terms of carbon emissions, the conversion of croplands into built-up land contributed the most. The spatial distribution of carbon emissions in Shaanxi was ranked as follows: Central Shaanxi > Northern Shaanxi > Southern Shaanxi. Local spatial agglomeration was reflected in the cold spots around Xi'an, and hot spots around Yulin. With respect to the principal driving factors, the gross domestic product (GDP) was the dominant factor affecting most of the carbon emissions induced by land cover and land use change in Shaanxi, and socioeconomic factors generally had a greater influence than natural factors. Socioeconomic variables also showed evident spatial heterogeneity in carbon emissions. The results of this study may aid in the formulation of land use policy that is based on reducing carbon emissions in developing areas of China, as well as contribute to transitioning into a "low-carbon" economy.

Comparison of DWI and 18F-FDG PET/CT for assessing preoperative N-staging in gastric cancer: evidence from a meta-analysis.

The diagnostic values of diffusion weighted imaging (DWI) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for N-staging of gastric cancer (GC) were identified and compared. After a systematic search to identify relevant articles, meta-analysis was used to summarize the sensitivities, specificities, and areas under curves (AUCs) for DWI and PET/CT. To better understand the diagnostic utility of DWI and PET/CT for N-staging, the performance of multi-detector computed tomography (MDCT) was used as a reference. Fifteen studies were analyzed. The pooled sensitivity, specificity, and AUC with 95% confidence intervals of DWI were 0.79 (0.73-0.85), 0.69 (0.61-0.77), and 0.81 (0.77-0.84), respectively. For PET/CT, the corresponding values were 0.52 (0.39-0.64), 0.88 (0.61-0.97), and 0.66 (0.62-0.70), respectively. Comparison of the two techniques revealed DWI had higher sensitivity and AUC, but no difference in specificity. DWI exhibited higher sensitivity but lower specificity than MDCT, and 18F-FDG PET/CT had lower sensitivity and equivalent specificity. Overall, DWI performed better than 18F-FDG PET/CT for preoperative N-staging in GC. When the efficacy of MDCT was taken as a reference, DWI represented a complementary imaging technique, while 18F-FDG PET/CT had limited utility for preoperative N-staging.