Ankle Exoskeleton Assistance Can Improve Over-Ground Walking Economy in Individuals With Cerebral Palsy.

Individuals with neuromuscular impairment from conditions like cerebral palsy face reduced quality of life due to diminishing mobility and independence. Lower-limb exoskeletons have potential to aid mobility, yet few studies have investigated their use during over-ground walking - an exercise that may contribute to our understanding of potential benefit in free-living settings. The goal of this study was to determine the potential for adaptive plantar-flexor assistance from an untethered ankle exoskeleton to improve over-ground walking economy and speed. Six individuals with cerebral palsy completed three consecutive daily over-ground training sessions to acclimate to, and tune, assistance. During a final assessment visit, metabolic cost, walking speed, and soleus electromyography were collected for baseline, unpowered, low, training-tuned, and high assistance conditions. Compared to each participant's baseline condition, we observed a 3.9 ± 1.9% (p = 0.050) increase in walking speed and a 22.0 ± 4.5% (p = 0.002) reduction in soleus activity with training-tuned assistance; metabolic cost of transport was unchanged (p = 0.130). High assistance resulted in an 8.5 ± 4.0% (p = 0.042) reduction in metabolic cost of transport, a 6.3 ± 2.6% (p = 0.029) increase in walking speed, and a 25.0 ± 4.0% (p < 0.001) reduction in soleus activity. Improvement in exoskeleton-assisted walking economy was related to pre-training baseline walking speed ( [Formula: see text], p = 0.001); the slower and more impaired participants improved the most. Energy cost and preferred walking speed remained generally unchanged for the faster and less impaired participants. These findings demonstrate that powered ankle exoskeletons have the potential to improve mobility-related outcomes for some people with cerebral palsy.

Adaptive Ankle Resistance from a Wearable Robotic Device to Improve Muscle Recruitment in Cerebral Palsy.

Individuals with cerebral palsy can have weak and poorly coordinated ankle plantar flexor muscles that contribute to inefficient walking patterns. Previous studies attempting to improve plantar flexor function have had inconsistent effects on mobility, likely due to a lack of task-specificity. The goal of this study was to develop, validate, and test the feasibility and neuromuscular response of a novel wearable adaptive resistance platform to increase activity of the plantar flexors during the propulsive phase of gait. We recruited eight individuals with spastic cerebral palsy to walk with adaptive plantar flexor resistance provided from an untethered exoskeleton. The resistance system and protocol was safe and feasible for all of our participants. Controller validation demonstrated our ability to provide resistance that proportionally- and instantaneously-adapted to the biological ankle moment (R = 0.92 ± 0.04). Following acclimation to resistance (0.16 ± 0.02 Nm/kg), more-affected limbs exhibited a 45 ± 35% increase in plantar flexor activity (p = 0.02), a 26 ± 24% decrease in dorsiflexor activity (p < 0.05), and a 46 ± 25% decrease in co-contraction (tibialis anterior and soleus) (p = 0.02) during the stance phase. This adaptive resistance system warrants further investigation for use in a longitudinal intervention study.

Closing the Loop on Exoskeleton Motor Controllers: Benefits of Regression-Based Open-Loop Control.

Lower-limb exoskeletons are widely researched to improve walking performance and mobility. Low-level sensor-less exoskeleton motor control is attractive for consumer applications due to reduced device complexity and cost, but complex and variable transmission system configurations make the development of effective open-loop motor controllers that are responsive to user input challenging. The objective of this study was to develop and validate an open-loop motor control framework resulting in similar or greater performance vs. closed-loop torque control. We used generalized linear regression to develop two open-loop controllers by modeling motor current during exoskeleton-assisted walking; a "complex" model used desired torque and estimated ankle angular velocity as inputs, while a "simple" model used desired torque alone. Five participants walked at 1.0-1.3 m/s on a treadmill with closed-loop and both open-loop controllers providing ankle exoskeleton assistance. Both open-loop current controllers had similar root-mean-squared torque tracking error (p=0.23) compared to the closed-loop torque-feedback controller. Both open-loop controllers had improved relative average torque production (p<0.001 complex, p=0.022 simple), lower power consumption (p<0.001 for both), and reduced operating noise (p=0.002 complex, p<0.001 simple) over the closed-loop controller. New control models developed for a different ankle exoskeleton configuration showed similar improvements (lower torque error, greater average and peak torque production, lower power consumption) over closed-loop control during over-ground walking. These results demonstrate that our framework can produce open-loop motor controllers that match closed-loop control performance during exoskeleton operation.

Proportional Joint-Moment Control for Instantaneously Adaptive Ankle Exoskeleton Assistance.

Lower-limb exoskeletons used to improve free-living mobility for individuals with neuromuscular impairment must be controlled to prescribe assistance that adapts to the diverse locomotor conditions encountered during daily life, including walking at different speeds and across varied terrain. The goal of this paper is to design and establish clinical feasibility of an ankle exoskeleton control strategy that instantly and appropriately adjusts assistance to the changing biomechanical demand during variable walking. To accomplish this goal, we developed a proportional joint-moment control strategy that prescribes assistance as a function of the instantaneous estimate of the ankle joint moment and conducted a laboratory-based feasibility study. Four individuals with neuromotor impairment and one unimpaired individual completed exoskeleton-assisted slow and fast gait transition tasks that involved gait initiation and changing walking speed. We found that the controller was effective in instantaneously prescribing exoskeleton assistance that was proportional to the ankle moment with less than 14% root-mean-square error, on average. We also performed a three-subject pilot investigation to determine the ability of the proportional joint-moment controller to improve walking economy. Evaluated in two individuals with cerebral palsy and one unimpaired individual, metabolic cost of transport improved 17-27% during treadmill and over-ground walking with proportional control compared with wearing the exoskeleton unassisted. These preliminary findings support the continued investigation of proportional joint-moment control for assisting individuals with neuromuscular disabilities during walking in real-world settings.

An Untethered Ankle Exoskeleton Improves Walking Economy in a Pilot Study of Individuals With Cerebral Palsy.

The high energy cost of walking in individuals with cerebral palsy (CP) contributes significantly to reduced mobility and quality of life. The purpose of this paper was to develop and clinically evaluate an untethered ankle exoskeleton with the ability to reduce the metabolic cost of walking in children and young adults with gait pathology from CP. We designed a battery-powered device consisting of an actuator-and-control module worn above the waist with a Bowden cable transmission used to provide torque to pulleys aligned with the ankle. Special consideration was made to minimize adding mass to the body, particularly distal portions of the lower-extremity. The exoskeleton provided plantar-flexor assistance during the mid-to-late stance phase, controlled using a real-time control algorithm and embedded sensors. We conducted a device feasibility and a pilot clinical evaluation study with five individuals with CP ages five through thirty years old. Participants completed an average of 130 min of exoskeleton-assisted walking practice. We observed a 19±5% improvement in the metabolic cost of transport (p = 0.011) during walking with untethered exoskeleton assistance compared to how participants walked normally. These preliminary findings support the future investigation of powered ankle assistance for improving mobility in this patient population.