Botulinum Toxin Injections as an Adjunct to Surgical Lip Repositioning For Gummy Smile Treatment.

BACKGROUND: An attractive smile depends on the proper proportion and arrangement of lip, teeth gingiva scaffold. The ideal smile is the exposure of the entire length of maxillary teeth with 1 mm gingiva. A gingival display exceeding 3 mm is unpleasant and termed ''gummy smile (GS).'' Lip repositioning is a simple surgical procedure intended to minimize the gingival display by removing a strip of mucosa and shortening the vestibular depth. Botulinum toxin injecting overactive muscles with measured quantities results in a reduction of muscle activity, relaxing the lip muscles and decreasing upward pull on the lip. There are some contraindications: patients with short lips and gingival exposures less than 3 mm. PURPOSE: This case report describes the successful management of GS of a young man. CASE REPORT: The procedures were performed and these techniques resulted in shortened vestibule and restricted the muscle pull of the elevator muscles of the lip, reducing gingival display when the patient smiles. Surgical lip repositioning can be a minimally invasive alternative to orthognathic surgery. Botulinum Toxin injections can be a useful adjunct to enhance the esthetics and improve patient satisfaction, being a more conservative and immediate nonsurgical treatment modality available. CONCLUSIONS: In this way, the clinical case report demonstrated that lip repositioning surgery combined to botulinum toxin injections promising outcomes in the GS correction. The effect showed a marked reduction in gingival display at the 4-years follow-up.

Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats.

OBJECTIVES: Alendronate and raloxifene, a bisphosphonate and a selective estrogen modulator, respectively, are established osteoporosis therapies. Current evidence suggests that simultaneous application of osteoporosis therapies modulates osseointegration. However, alendronate shows inconsistent findings and raloxifene has not been studied comprehensively. This study aimed to evaluate the bone dynamics and molecular and microstructural features at the peri-implant bone interface in osteoporotic rats. MATERIALS AND METHODS: Thirty female rats underwent ovariectomy and were fed a diet low in calcium and phosphate and treated with alendronate or raloxifene for 30 days or underwent fictional ovariectomy surgery (SHAM) prior to implant insertion in the tibia; osteoporosis therapies continued thereafter. After 42 days, peri-implant bone was evaluated by histometric and micro-CT analysis. Fluorochrome incorporation and gene expression was determined to evaluate bone turnover. RESULTS: We report here that alendronate had no impact on bone-to-implant contacts and the mineral apposition rate. The RANKL/OPG ratio and local bone volume, however, were increased compared to the untreated osteoporotic rats. Even though signaling to bone resorption activity through RANKL production was observed in the alendronate group, the blockade of bone resorption activity that occurs in decorrence to alendronate activity took place and resulted in an increase in bone volume. Raloxifene significantly increased osseointegration in osteoporotic rats, as indicated by bone-to-implant contacts, mineral apposition, and local bone volume. Raloxifene, however, had no considerable impact on the RANKL/OPG ratio compared to untreated osteoporotic rats. As expected, the SH group showed higher bone-to-implant contacts and mineral apposition rates than the untreated osteoporotic rats. CONCLUSIONS: These findings suggest that raloxifene but not alendronate can compensate for the impaired osseointegration in osteoporotic rats. CLINICAL RELEVANCE: Regarding the superiority of raloxifene observed in the improvement of bone dynamics response, this statement suggests that raloxifene could be a good option for osteoporosis patients in oral rehabilitation procedures.

Immunohistochemistry evaluation of BMP-2 with ß-tricalcium phosphate matrix, polylactic and polyglycolic acid gel, and calcium phosphate cement in rats.

PURPOSE: The installation of implants has become a routine procedure in the clinic. However, it takes time and adequate bone thickness, and for that, tissue engineering has made efforts to develop substitutes for autografts, in view of certain disadvantages of this material. The decision to choose the most suitable graft material for each case is an important step in the success of bone reconstruction. This study was to verify, by means of immunohistochemical study, that the addition of bone morphogenetic protein had some influence on biomaterials commercially available, taking into account the formation of mineralized tissue, bone replacement, and the amount of degradation of biomaterials. METHODS: The sample consisted of 72 rats that were divided into eight treatment groups, in which two defects of 5 mm were made in each animal calvaria. Euthanasia was performed at 5, 15, and 30 days postop. RESULTS: A histologic and histometric analysis was performed to quantitate the area of mineralized tissue formed, the area of newly formed bone, and the area of degradation of the biomaterials. Data were analyzed with multiple comparisons of means by Tukey contrasts, and significant difference was assigned at the level of P < 0.05. The proteins used for immunohistochemical analysis accounted for the process of formation, mineralization, and bone resorption and was performed using ordinal qualitative analysis, where from assigning scores. CONCLUSIONS: Bone morphogenetic protein 2 was shown to be effective as an inducer of bone formation process independent biomaterial used mainly for accelerating the resorption process of the framework.

Evaluation of the Osteoinductive Effect of PDGF-BB Associated With Different Carriers in Bone Regeneration in Bone Surgical Defects in Rats.

PURPOSE: Extensive bone defects in maxillofacial region can be corrected with autograft. However the disadvantages of this type of therapy lead to the search for new bone substitutes. Thus, we evaluated the biological behavior and osteoinductive platelet-derived growth factor type BB (PDGF-BB) associated with different carriers, by histological analysis and immunohistochemical histometric critical defects performed in rat calvaria. MATERIALS AND METHODS: Critical defects were created with 5-mm diameter calvaria of rats. Each defect was randomly divided into 8 experimental groups, evaluated at 15 and 30 postoperative days for histomorphometry and immunohistochemistry. RESULTS: The results showed new bone formation in all groups, independent of postoperative time. At 30 days, the beta-tricalcium phosphate matrix (TCP) group just did not differ from bone matrix mineralized bovine (BIO) group in the new bone formation (P = 0.1403). In none of the groups' analyzed biomaterials, growth factor stimulated increase in bone formation (P > 0.05). CONCLUSION: With the methodology used, the growth factor associated with the tested biomaterials did not induce new bone formation.

Immunohistochemical response in rats of beta-tricalcium phosphate (TCP) with or without BMP-2 in the production of collagen matrix critical defects.

This study aimed to assess the biological response of BMP-2 (bone morphogenetic protein-2) in supplementation with ß-tricalcium phosphate (TCP) as a carrier in the bone healing of surgical defects in rats' calvaria. A critical-size defect (5mm in diameter) was filled with ß-TCP alone or added with that plus 5mg of BMP-2 at 5, 15, and 30 postoperative days. Histomorphometric and immunohistochemical (osteocalcin, collagen type I, and metalloproteinase-9) analysis was performed to assess the features of bone healing. Histological behavior and collagen type I labeling showed increased formation of the collagen matrix, leading to a higher percentage of newly formed bone and biomaterial for tissue and more total mineralization of pure TCP when compared to the other groups. The supplementation with BMP-2 promoted faster TCP remodeling; however, there was no statistically significant difference for the bone formed in both groups (P>0.05). Collagen-matrix formation and new bone formation reached maximum levels when the defects were filled with pure TCP, even exceeding the levels from BMP-2 supplementation.

Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats.

OBJECTIVES: The aim of this study is to evaluate the alendronate and raloxifene influence in the alveolar healing process of osteoporotic rats. MATERIALS AND METHODS: Sixty-four female rats were divided in four groups: sham rats (SHAM), ovariectomized rats and no medical treatment (OVX NT), ovariectomized rats and submitted to alendronate treatment (OVX ALE), and ovariectomized and submitted to raloxifene treatment (OVX RAL). The histomorphometrical and immunohistochemical analysis was performed. The quantitative data were analyzed through Kruskal-Wallis and Dunn tests (α = 0.05). RESULTS: In the longest period, SHAM and OVX RAL groups showed the better bone formation responses (P < 0.05). The worst bone formation response was observed in the group OVX NT. OVX RAL group showed the better response at 42 days. OVX ALE group showed a favorable response at 14 days, in comparison with OVX RAL group, but a reduced response at 42 days. It was possible to observe a mature bone in SHAM group at 14 days and an immature bone in the OVX NT group. An intermediate quality bone was observed in the groups OVX ALE and OVX RAL. CONCLUSION: Alendronate and raloxifene treatment improved the alveolar healing process in osteoporotic rats, but not enough to achieve the histometrical and protein expression values that were observed in the SHAM group. CLINICAL RELEVANCE: Alendronate is largely used as a potent antiresorptive agent. Otherwise, considering the undesirable effects in relation to the alveolar healing, other antiosteoporosis medications should be studied. Raloxifene seems to be a good candidate once its action mechanism involves the activation of osteoblasts.

Evaluation of bone substitutes for treatment of peri-implant bone defects: biomechanical, histological, and immunohistochemical analyses in the rabbit tibia.

PURPOSE: We sought to evaluate the effectiveness of bone substitutes in circumferential peri-implant defects created in the rabbit tibia. METHODS: Thirty rabbits received 45 implants in their left and right tibia. A circumferential bone defect (6.1 mm in diameter/4 mm depth) was created in each rabbit tibia using a trephine bur. A dental implant (4.1 mm × 8.5 mm) was installed after the creation of the defect, providing a 2-mm gap. The bone defect gaps between the implant and the bone were randomly filled according to the following groups: blood clot (CO), particulate Bio-Oss(®) (BI), and Bio-Oss(®) Collagen (BC). Ten animals were euthanized after periods of 15, 30, and 60 days. Biomechanical analysis by means of the removal torque of the implants, as well as histologic and immunohistochemical analyses for protein expression of osteocalcin (OC), Runx2, OPG, RANKL, and TRAP were evaluated. RESULTS: For biomechanics, BC showed a better biological response (61.00±15.28 Ncm) than CO (31.60±14.38 Ncm) at 30 days. Immunohistochemical analysis showed significantly different OC expression in CO and BC at 15 days, and also between the CO and BI groups, and between the CO and BC groups at 60 days. After 15 days, Runx2 expression was significantly different in the BI group compared to the CO and BC groups. RANKL expression was significantly different in the BI and CO groups and between the BI and BC groups at 15 days, and also between the BI and CO groups at 60 days. OPG expression was significantly higher at 60 days postoperatively in the BI group than the CO group. CONCLUSIONS: Collectively, our data indicate that, compared to CO and BI, BC offered better bone healing, which was characterized by greater RUNX2, OC, and OPG immunolabeling, and required greater reversal torque for implant removal. Indeed, along with BI, BC presents promising biomechanical and biological properties supporting its possible use in osteoconductive grafts for filling peri-implant gaps.

Guided Surgery in Esthetic Region.

The placement of dental implants and subsequent placement of immediate temporary dentures after extractions has become a treatment modality accepted by the scientific community. In addition to the functional factor, the surgical procedure in a single stage in the anterior region of the maxilla offers an esthetic appearance, and relieves the psychological concerns of patients. To guarantee the success and longevity of treatments performed, the fabrication of surgical guides is a helpful method in these situations. Guided surgery has gained attention because it restores esthetics with immediate restoration, provides the patient with comfort in addition to dispensing with the need for performing surgical flaps. This auxiliary method allows the position and design of the implant, as well as the perforation sequence to be programmed, thus optimizing the clinical results. In this study, the authors present a clinical case of a patient who was submitted to extraction and subsequent implant placement with immediate loading in the anterior region of the maxilla, performed in a satisfactory manner.

A utilização do ácido hialurônico para ganho vertical de papila em área estética / The use of hyaluronic acid for vertical papilas formation in the esthetic zone

Defeitos mucogengivais em decorrência do avanço da doença periodontal resultam em perda óssea alveolar e consequente migração apical da papila interdental, levando à formação de triângulos negros que comprometem a estética do paciente. O tratamento de defeitos mucogengivais e peri-implantares vem sendo amplamente estudado no sentido de otimizar os resultados clínicos alcançados e são considerados um grande desafio na prática clínica. Assim, o presente estudo buscou avaliar a eficácia clínica de um novo método para eliminar ou reduzir pequenos defeitos de papila, utilizando-se o gel de ácido hialurônico (AH). A utilização de gel de AH, comercialmente disponível, foi utilizado em dois casos clínicos como um método possível de formação de papila entre implantes, e em áreas de pôntico de prótese fixa sobre implantes em regiões estéticas da maxila. Os pacientes incluídos neste estudo apresentavam- -se com pelo menos um defeito de papila na região anterior. Antes do tratamento, fotografias da condição inicial dos pacientes foram obtidas. O procedimento clínico para aplicação do gel de AH (0,2 mL) foi realizado com anestesia tópica, após profilaxia, utilizando-se um dispositivo apropriado, 2-3 mm apical à borda coronária da papila envolvida. Reavaliações periódicas a cada 3 semanas foram conduzidas, e a aplicação do gel de AH foi repetida por três vezes. Os pacientes foram acompanhados durante um período de seis meses após a aplicação do gel e fotografias foram obtidas para comparação dos resultados alcançados. Os resultados mostraram satisfatório aumento do volume tecidual nos dois casos tratados, os quais resultaram em um maior preenchimento tecidual e consequente melhora das condições estéticas dos pacientes. Em conclusão, os resultados do presente estudo são encorajadores, evidenciando que pequenos defeitos de papila interdentária entre pônticos e entre implantes podem ser solucionados por meio da aplicação clínica do gel de AH, resultando em satisfatório ganho tecidual com baixa morbidade ao paciente (AU)

Mucogingival defects as a consequence of the advancement of periodontal disease result in bone loss and subsequent apical migration of the interdental papilla, leading to the formation of black triangles that compromise the patient aesthetics. The treatment of mucogingival and peri-implant defects is considered a major challenge in clinical practice and has been widely studied in order to optimize clinical results. Thus, the present study sought to evaluate the clinical effectiveness of a new method to eliminate or reduce small papillary defects, using the hyaluronic acid gel (HA). The HA gel, commercially available, was used in two cases as a possible method for the formation of papilla between implants and in pontics region of implant-supported prostheses in the anterior maxillary region. The patients included in this study had at least one papillary defect in the anterior region. Before treatment, photographs of the initial condition of all patients were obtained. The clinical procedure for the application of the HA gel (0.2 mL) was performed under topic anesthesia, after dental prophylaxis, using an appropriate device, 2-3 mm apical to the coronal tip of the involved papilla. Patients were seen every 3 weeks, and the application of the HA gel was repeated three times. Patients were followed for a period of six months after the HA gel application and photographs were taken for results comparison. Satisfactory increased tissue volume was observed in all cases, which resulted in greater tissue filling and consequent improvement of aesthetic conditions. In conclusion, the results of the present study are encouraging, showing that small defects of interdental papilla between implants and prosthetic pontic can be solved through clinical application of HA gel resulting in satisfactory tissue gain with low morbidity to the patient (AU)

Hypertension modifies OPG, RANK, and RANKL expression during the dental socket bone healing process in spontaneously hypertensive rats.

OBJECTIVE: The aim of this study was to evaluate the dental socket bone healing process by histomorphometric and immunohistochemical analysis of osteoprotegerin (OPG), receptor activator of nuclear factor-κß (RANK), and receptor activator of nuclear factor-κß ligand (RANKL) proteins in spontaneously hypertensive rats (SHR). MATERIALS AND METHODS: Under general anesthesia, 25 Wistar rats and 25 SHRs underwent upper right incisor extraction. Rats were euthanized after 7, 14, 21, 28, or 42 days of dental extractions. Histomorphometric and immunohistochemical analyses of OPG, RANK, and RANKL proteins were performed. RESULTS: Histomorphometric results showed decreased bone healing and reduced bone trabecular thickness in SHRs. Immunohistochemical reactions showed intense RANKL and RANK immunolabeling at 14 and 28 postoperative days and mild OPG immunolabeling at 7, 14, and 21 days after surgery in SHRs. CONCLUSION: The results of this study show that RANK, RANKL, and OPG immunolabeling was altered in SHRs, and these results are associated with bone healing delay and decreased trabecular thickness in SHRs. CLINICAL RELEVANCE: Hypertension alters the expression of RANK, RANKL, and OPG and delays the socket bone healing process. These alterations could influence some dental procedures such as orthodontic treatment and implant placement.

História de avulsão e reabsorção por substituição 12 anos depois da reimplantação dentária – os benefícios da colocação tardia do implante na zona estética: controle clínico e radiográfico de quatro anos / A history of avulsion and resorption by substitution after 12 years of tooth reimplantation – the benefi ts of delayed implant placement in the esthetic zone: a 4-year clinical and radiographic follow-up

O traumatismo dentário desperta atenção na Odontologia, devido ao comprometimento estético e funcional que ocasiona. Dentre os traumas, a avulsão é uma das principais questões por ser uma lesão grave e envolver danos complexos ao ligamento periodontal. O tratamento de escolha é o reimplante dentário. O objetivo deste estudo foi apresentar a abordagem do trauma dental em um paciente que sofreu avulsão dos dentes 11 e 21. Os elementos foram reimplantados duas horas após o trauma, caracterizando o caso como reimplante tardio. Foi realizada endodontia de ambos os dentes e, após 12 anos de acompanhamentos clínico e radiográfico, houve necessidade de extração dos elementos 11 e 21 devido à presença de grandes áreas de reabsorção por substituição na porção radicular. Implantes osseointegráveis foram instalados na mesma sessão, a fim de reabilitar o paciente que nesse momento apresentava maturidade óssea, estando apto a receber o implante. O caso se encontra com quatro anos de acompanhamento e nenhuma sintomatologia clínica foi observada. Frente à avulsão dentária, o reimplante ainda é a conduta ideal mesmo quando há necessidade de um futuro implante devido à ocorrência das reabsorções dentárias, pois quanto maior a permanência do dente reimplantado no alvéolo, maior a preservação do osso alveolar que mantém sua forma e espessura, favorecendo assim também a estética e pela possibilidade de postergar as cirurgias para colocação dos implantes.

Tooth trauma demands attention in Dentistry due to its esthetic and functional impairments. Avulsion is one of the main issues regarding its severity and complex damage to the periodontal ligament. The treatment of choice is reimplantation. The aim of this article is to present an approach to avulsed teeth 11 and 21. Both elements were reinserted 2 hours later, which characterizes a delayed reimplantation. After endodontic treatment, as well as 12 years of clinical and radiographic follow-up, those teeth were extracted due to large root resorption areas. Dental implants were installed in the same session but now the patient presented with excellent bone maturity to receive the implants. This case now has 4 years of follow-up and no clinical symptomatology was reported. In case of tooth avulsion, the reimplantation is the ideal option aiming for further implant placement due to tooth resorption, because the longer a tooth can be kept in its alveolar socket, the more the bone contour and width preservation are seen, also favoring esthetics and postponing of dental implant surgeries.

Healing process of autogenous bone graft in spontaneously hypertensive rats treated with losartan: an immunohistochemical and histomorphometric study.

PURPOSE: Hypertension is a major risk factor for cardiovascular diseases, which has been related to such changes as gradual bone loss and a decrease in bone mass index. The cellular and molecular mechanisms that involve hypertension and osteoporosis are not fully understood. Many patients have high blood pressure, controlled or uncontrolled, and may use at least 1 antihypertensive drug, and an understanding of the interference of hypertension with bone healing is very important when considering oral rehabilitation with implants and bone grafts. This study investigated the interference of hypertension in bone metabolism during the repair process of autogenous bone grafting and analyzed the influence of losartan, an antihypertensive drug and angiotensin II receptor antagonist, through histometric and immunohistochemical analyses by examining the protein expressions of osteocalcin, osteoprotegerin, receptor activator of nuclear factor-κB, receptor activator of nuclear factor-κB ligand, tartrate-resistant acid phosphatase, vascular endothelial growth factor, and platelet endothelial cell adhesion molecule. MATERIALS AND METHODS: The groups studied include 24 normotensive Wistar rats and 24 spontaneously hypertensive rats divided into groups treated and not treated with losartan. Rats were subjected to block bone graft surgery in the mandible and were sacrificed at 7, 14, and 28 days. RESULTS: Histometric analysis was performed to evaluate the amount of bone tissue formed at the interface of the recipient bed and bone graft. The total area of formed bone tissue was outlined and calculated. Immunohistochemical analysis was semi-quantitative and the significance of the differences between groups regarding the percentage of newly formed bone tissue interface and protein expression were determined by ANOVA analysis of variance and Kruskall-Wallis followed by Tukey test or Holm Sidak to detect differences between groups. The results were considered statistically significant when P<.05. CONCLUSION: The untreated hypertensive rats showed a delay in the repair of autogenous bone block grafts compared with untreated Wistar rats. Furthermore, the use of losartan for lowering blood pressure in these animals was shown to improve the healing process, despite not showing important statistical differences.

Resolução simplificada pela conversão de uma prótese parcial fixa/removível de extensão distal em uma overdenture maxilar retida por implantes / A simple treatment way by conversion of a distal extension fixed/removable bridge into an implant-retained maxillary overdenture: a case report

Este trabalho relata um caso clínico onde uma paciente de 82 anos de idade queixava-se da instabilidade da porção removível de sua prótese maxilar híbrida. Dois implantes foram colocados na região posterior e a nova prótese passou a funcionar como uma overdenture retida por encaixes tipo O-ring. As extremidades distais dos encaixes nas coroas metalocerâmicas dos dentes 13 e 23 não puderam ser capturadas. Mesmo em função das limitações técnicas e econômicas, o tratamento proposto satisfez as exigências estéticas e funcionais da paciente.

This work reports a clinical case where a 82 years-old patient had complaints about the removable portion of an hybrid maxillary prosthesis. Two dental implants were inserted in the posterior region and the new reconstruction was designed as an O-ring retained overdenture. The female portions of the metalloceramic crowns of teeth 13 and 23 could not be captured in this way. Even thus, given the technical and financial limitations, the proposed treatment addressed all esthetic and functional patient demands

Multidisciplinary approach for crown-root fracture treatment after trauma: case report / Abordagem multidisciplinar para tratamento de fratura corono-radicular pós-traumatismo: relato de caso

The development of an accurate diagnosis and appropriate treatment plan can be a complex task, especially in cases of dentoalveolar trauma. The authors present a case report of crown-root fracture caused by trauma and highlight the importance of a multidisciplinary approach for the treatment. An eighteen year-old boy had a bicycle accident resulting in dental trauma. The upper right first molar showed a complicated crownroot fracture and the lower left second pre-molar showed an uncomplicated crown-root fracture. Endodontic treatment, controlled tooth extrusion, periodontal surgery for recovery of biological width, and porcelain crown and onlay restorations were performed. Esthetic and functional results were achieved. At the two-year follow-up it was observed that the tooth/onlay interface of the upper right first molar was stained and the onlay of the left lower second pre-molar was fractured. Therefore, the interface stained was repaired and a porcelain crown was made for the lower second premolar. The clinical case presented herein leads to the conclusion that a multidisciplinary treatment plan is extremely important for a proper resolution in cases of dentoalveolar trauma

A elaboração de um diagnóstico preciso e de um plano de tratamento adequado pode constituir uma tarefa bastante complexa, especialmente nos casos de traumatismos dentoalveolares. O relato de caso teve por finalidade demonstrar a importância da abordagem multidisciplinar para o tratamento de fratura corono-radicular pós traumatismo. Paciente de 18 anos de idade, gênero masculino, sofreu uma queda de bicicleta resultando em traumatismos dentários. O 16 sofreu fratura corono-radicular complicada e o 35 fratura corono-radicular não-complicada. Foi realizado tratamento endodôntico, extrusão dentária controlada, cirurgia periodontal para recuperação do espaço biológico, coroa de porcelana e restauração tipo onlay. O resultado estético e funcional foi alcançado. O paciente foi acompanhado por 2 anos onde foi observado um manchamento na interface dente/onlay do 16 e fratura da onlay do 35. Foi realizado um reparo na interface do 16 e confeccionada uma coroa de porcelana para o 35. Foi possível concluir que a multidisciplinaridade do plano de tratamento é de extrema importância para uma adequada resolução dos casos de traumatismos dentoalveolares

Importance of clinical examination in dentoalveolar trauma.

Dental injuries are often the result of direct trauma. The most affected teeth are the upper incisors, and the most frequent lesions are coronal fractures, contusions, and lip and alveolar mucosa lacerations. The objective of this study was to draw attention to the importance of the correct management of cases of crow fractures associated with soft tissue lacerations when the fragment is not located. This is a clinical case of crown fracture, the fragment of which remained lodged inside the lip. After fragment removal, the clinical case showed a satisfactory repair emphasizing the importance of a meticulous clinical examination to achieve a correct diagnosis and an appropriate treatment plan, which is essential for a favorable prognosis.

Anterior tooth rehabilitation with frozen homogenous bone graft and immediately loaded titanium implant using computer-guided surgery.

Computed tomographic scanning is a precise, noinvasive surveying technique that enables the professionals to improve the precision of implant placement by building a prototype that allows the confection of surgical guides. The authors present a clinical case of anterior tooth rehabilitation with frozen homogenous bone graft and immediately loaded titanium implant using computer-guided surgery. A multislice computed tomography was realized, and a prototype was built. All the procedures were previously realized in the prototype before started in the patient. This technique allows a better surgical planning, makes the procedures more accurate, and reduces surgery time.