RESUMO
The active fraction extracted from dragon's blood displayed an inhibitory effect on alpha-glucosidase activity with an IC50 of 0.152 microg/mL, which is nearly half of the crude material. Its inhibition on alpha-glucosidase was noncompetitive. In addition, when this fraction was orally administered to mice dosed with Acarbose (20 mg/kg), the active fraction (100, 300, 500 mg/kg) significantly suppressed increase of blood glucose levels after sucrose loading in a dose-dependent manner. These results suggest that this extract from dragon's blood exerts an anti-diabetic effect by suppressing intestinal carbohydrate absorption and thereby reducing the postprandial increase of blood glucose.
Assuntos
Diabetes Mellitus Experimental/tratamento farmacológico , Dracaena/química , Inibidores de Glicosídeo Hidrolases , Hipoglicemiantes/isolamento & purificação , Extratos Vegetais/uso terapêutico , Acarbose , Animais , Glicemia/efeitos dos fármacos , Metabolismo dos Carboidratos/efeitos dos fármacos , Diabetes Mellitus Experimental/induzido quimicamente , Inibidores Enzimáticos/uso terapêutico , Absorção Intestinal , CamundongosRESUMO
A new dihydrochalcone, 4'-hydroxy-4,2'-dimethoxy-dihydrochalcone, was isolated from Chinese dragon's blood, the red resin of Dracaena cochinchinensis. Its structure was established by spectrum analysis.
