RESUMO
We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences).
Assuntos
Asma/genética , Dermatite Atópica/genética , Glutationa Transferase/genética , Polimorfismo Genético , Alelos , Criança , Feminino , Genótipo , Homozigoto , Humanos , Isoleucina/química , Masculino , Razão de Chances , Risco , Federação Russa , Valina/química , Xenobióticos/farmacologiaRESUMO
The frequency of individual genotypes GSTM1, GSTT1, and GSTP1 and haplotypes was determined in patients with atopic dermatitis and healthy children. The actual frequency of some haplotypes was far below the theoretical value. Some haplotypes were associated with predisposition and resistance to atopic dermatitis.
