[Activity of the anthelmintic agent trichlorophen on the models of human helminthiasis]. / Aktivnost' otechestvennogo antigel'mintika trikhlofena na modeliakh gel'mintozov cheloveka.

Trials of trichlorophen have shown its high efficacy on models of cestode infections: hymenolepiasis (at the adult and cysticercoid stages of development on three types of animals: outbred albino mice, albino rats and golden hamsters), preimaginal echinococciasis alveolaris, larval alveolar echinococciasis (at the early stage of development of the parasite in experiments on cotton rats). The high nematodical activity of trichlorophen was first found on models of trichocephaliasis in DBA/2y mice, nippostrongyloidiasis (in in vitro experiments), and aspiculuriasis in outbred mice. The agent proved to be ineffective at the tissue developmental stage of Hymenolepsis nana (H. nana), the dwarf tapeworm, in albino mice, during experimental opisthorchiasis in golden hamsters. It showed a low efficacy in treating trichinosis in outbred albino mice. Unlike carbamatebenzimidazoles, trichlorophen was inactive at the tissue stage of H. nana; it exerted no effects on the eggs of a dwarf tapeworm in trichinosis. Trichlorophen was also inactive in treating experimental opisthorchiasis in golden hamsters.

[A comparative study of the efficacy of medamine, albendazole and embovin in models of syphaciasis and aspiculariasis]. / Sravnitel'noe issledovanie éffektivnosti medamina, al'bendazola i émbovina na modeliakh sifatsioza i aspikuliroza.

The study covers the study of three antinematodal agents: the original national drug medamine with albendazole and embovin (pyrathel pamoate), which have been reproduced at the E. I. Martsinovskii Institute of Medical Parasitology and Tropical Medicine, with murine Syphacia obvelata and Aspiculuris tetraptera infection models. The quantitative parameters of the anthelmintic action of medamine, albendazole and embivin were comparatively defined for the first time.

[A luminescence microscopy method for studying organ function in Aspiculuris tetraptera (Schulz, 1924)]. / Liuminestsentno-mikroskopicheskii metod izucheniia funktsional'nogo sostoianiia organov Aspiculuris tetraptera (Schulz, 1924).

The paper proposes the rapid technique for examining the luminescence pattern of individual systems and organs in the murine parasite Aspiculuris tetraptera. The luminescence pattern of the parasite was studied after fluorochrome-plating with rhodamine 6G, rhodamine C, coryphosphine, sodium fluorescein, acridine orange which was found to be the optimum fluorochrome. This technique is to be used in the evaluation of the effects of chemopharmaceuticals on the parasite.

[The efficacy of a new Russian preparation metiazol in experimental aspiculariasis in mice]. / Izuchenie éffektivnosti novogo otechestvennogo preparata metiazola pri éksperimental'nom aspikuluroze u myshei.

The efficacy of metiasole, a new Russian analog of albendasole, reproduced at the E. I. Martsinovskii Institute of Medical Parasitology and Tropical Medicine, was studied in mice with Aspiculuris tetraptera invasion. Metiasole efficacy and acute toxicity were comparable to those of embovin and superior to those of medamin. Relationship between the drug efficacy and its doses and number of injections was analyzed.