RESUMO
UNLABELLED: The objective of this study is to develop a marker panel of abnormalities of immune regulatory systems and cell genome in patients with gastric cancer for assessment of efficacy of surgical treatment in combination with pharmaco-nutritional therapy in early postoperative period. MATERIALS AND METHODS: Expression of p53, sFAS, FASL, CEA, and CA 19-9, nutritial status, as well as incidence of purulent-septic complications in early postoperative period were determined in 40 patients with gastric cancer (21 patients--the test group and 19 patients--the comparative group) prior to a curative surgical intervention, postoperative days 1 and 7, while the pharmaco-nutritional therapy (the test group) or partial parenteral nutrition (the comparative group) has been performed. RESULTS: The pharmaco-nutritional therapy significantly decreases in activity of tumor suppressing genome, lymphocyte apoptosis, expression of oncology-associated markers, incidence of purulent-septic complications, as well as exacerbation risk for hypotrophy in patients with gastric cancer in early postoperative period. CONCLUSION: To assess the efficacy of the surgical intervention performed in patients with gastric cancer, an expression of mutant p53 and markers of lymphocyte apoptosis (sFAS/FASL) is reasonable to be evaluated together with determination of oncomarkers (CEA and CA 19-9).
Assuntos
Biomarcadores Tumorais/sangue , Estado Nutricional , Apoio Nutricional/métodos , Neoplasias Gástricas/cirurgia , Idoso , Antígeno CA-19-9/sangue , Antígeno Carcinoembrionário/sangue , Proteína Ligante Fas/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Soluções de Nutrição Parenteral , Valor Preditivo dos Testes , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/terapia , Proteína Supressora de Tumor p53/sangue , Receptor fas/sangueRESUMO
Nutrition support and molecular-genetic markers of the immune system at patients with complicated forms of gastric pathology. In this study presented results of surgery clinic of and oncology faculty SGMU to improve treatment patients with acute pancreatitis, and various forms of pancreonecrozis, through a balanced Threpsology support and operational gastrointestinal endoscopy.
Assuntos
Colangiopancreatografia Retrógrada Endoscópica , Nutrição Enteral/métodos , Pancreatite/terapia , Esfinterotomia Endoscópica , Doença Aguda , Adulto , Bilirrubina/análise , Diagnóstico Precoce , Feminino , Humanos , Lipase/análise , Masculino , Pessoa de Meia-Idade , Testes de Função Pancreática , Pancreatite/diagnóstico , Pancreatite/etiologia , Pancreatite/cirurgia , Pancreatite Necrosante Aguda/diagnóstico , Pancreatite Necrosante Aguda/etiologia , Pancreatite Necrosante Aguda/cirurgia , Pancreatite Necrosante Aguda/terapia , Resultado do Tratamento , Adulto Jovem , alfa-Amilases/sangueRESUMO
In this article the role of immunoregulative system and cellular genome (p53 and sFAS/FASL) pathology biomarkers and oncological markers (cancer fetal antigene and CA19-9) was estimated in results of surgical treatment in complex with the various kinds of a clinical nutrition in the early postoperative period after colon cancer.
