[Chronic course of latent urogenital tuberculosis].

This is a case report of an elderly patient with urogenital tuberculosis and concurrent tuberculosis of peripheral inguinal lymph nodes. The disease manifested by a fistulous form of inguinal lymphadenitis for 10 years and spread to the kidneys and genitals, but the patient did not seek medical attention. Changes on the glans penis prompted him to consult dermatovenereologist. Due to ineffective treatment and uncovering the scar in the inguinal area the patient was send to an anti-tuberculosis institution, where he was diagnosed with tuberculosis involving the kidneys, prostate, epididymis, penis, inguinal lymph nodes. The patient had a history of a contact with the patient with respiratory tuberculosis. Treatment with antituberculosis drugs produced a positive effect.

[Efficiency of lymphotropic intermittent chemotherapy in the complex treatment of patients with progressive pulmonary tuberculosis].

The study has established that during a progressive tuberculous process, immunological changes appear as significant increased proinflammatory cytokine production that leads to progressive destructive processes in the lung parenchymal lesion areas. Inclusion of lymphotrophic chemoimmunotherapy with roncoleukin into the complex therapy of patients with progressive pulmonary tuberculosis permits the optimization of the results of treatment in patients with progressive pulmonary tuberculosis due to the target delivery of antituberculous and immunoactive agents.

[Prevention of neuro- and cardiotoxic side effects of tuberculosis chemotherapy with noopept].

The study evaluated clinical efficiency of noopept used to prevent adverse side effects of antituberculous agents. It included 60 patients with newly diagnosed respiratory tuberculosis. Those in group 1 (n = 30) received 10 mg of noopept twice daily during the first month. The treatment promoted functional normalization of vegetative nervous system and antioxidative systems, reduced manifestations of anxiety, decreased frequency of adverse neuro- and cardiotoxic responses to antituberculous drugs.

[Antibiotic-associated diarrheas in phthisiatric care: standardization of their diagnosis, treatment, prevention, examination of health care quality].

The authors propose a phthisiological care-adjusted standard of the diagnosis, treatment, prevention of antibiotic-associated diarrhea. They have developed a standard-driven algorithm of expert assessment of the quality of medical aid to this group of patients.

[Infiltrative pulmonary tuberculosis in persons over 60 years of age].

To study the specific features of infiltrative pulmonary tuberculosis and its treatment efficiency in patients over 60 years, the authors analyzed case histories of 80 patients who were divided into 2 groups: 1) 40 patients aged 60 years or more and 2) 40 patients aged 18 to 50 years. The types of adaptive reactions (L. Kh. Garkavi et al., 1977) and those of the body's responsiveness (N. A. Brazhenko, 1987) were studied; the leukocytic shift index (N. I. Yabluchansky, et al., 1983) was calculated. The efficiency of treatment was evaluated from the results of control bacteriological and X-ray studies conducted after 2-, 5-, and 8-month drug therapy. The persons over 60 years of age were significantly more frequently (p < 0.05) diagnosed as having concomitant diseases (mainly coronary heart disease (65%), arterial hypertension (50%), chronic bronchitis (50%), atherosclerosis of central and peripheral arteries (35%), and adverse reactions caused by antituberculous drugs (75% versus 40%; among them there were prevalent neurotoxic and cardiotoxic reactions). Despite the fact that the results of treatment in this group of patients did not differ from those in young persons, which may be attributable to better compliance in patients above 60 years of age.

[Adverse neurotoxic reactions of chemotherapy for tuberculosis and their treatment].

A hundred and sixty-five first detected patients with pulmonary tuberculosis, receiving routine chemotherapy regimens were followed up for 4 months. Neurotoxic reactions of the central and peripheral nervous systems, which required isoniasid discontinuation, were developed in 13.3 and 11.5% of the patients, respectively. Therapy for neurotoxic reactions used cortexin in the study group (n = 22) and gamma or vitamins B in combination with glutaminic acid in the control group (n = 19). Cortexin used in the therapy of neurotoxic reactions produced a beneficial effect and permitted 90.9% of the patients to continue to use isoniazid while 42.2% of the controls resumed using isoniazid.

[Connective tissue metabolic parameters in differential diagnosis of infiltrative pulmonary tuberculosis and pneumonia in patients with signs of connective tissue dysplasia]. / Pokazateli metabolizma soedinitel'noi tkani v differentsial'noi diagnostike infil'trativnogo tuberkuleza legkikh i pnevmonii u patsientov s priznakami displazii soedinitel'noi tkani.

Connective tissue dysplasia is a systemic process that modifies the clinical picture and course of an acquired pathology. To search additional criteria for differential diagnosis, connective tissue metabolic parameters were studied in patients with infiltrative pulmonary tuberculosis and nosocomial pneumonia. A significant excess of the parameters of free urinary oxyproline and serum glycosaminoglycans was found in patients with infiltrative pulmonary tuberculosis.

[Implantation of an ultrasonic indicator into the pudendal artery to study the blood flow volume in the cow mammary gland]. / Implantatsiia ul'trazvukovogo datchika na naruzhnuiu sramnuiu arteriiu dlia prizhiznennogo opredeleniia ob''emnogo krovotoka vymeni u korov.

The cow mammary gland blood flow was found to equal 601.8 litres per a litre of milk at a daily yield 5 litres, whereas at a decreased daily yield (3.7 l/day) the blood flow was equal 452 litres per every litre of milk.

[The conservative treatment of acute hematogenous osteomyelitis in children]. / Shchadiashchee lechenie ostrogo gematogennogo osteomielita u detei.

Radioisotopes were used to study the water spaces of the bone and bone marrow in 47 dogs with a created model of acute osteomyelitis. By the 3rd-5th day of experimental osteomyelitis sharp hyperhydration of the bone marrow and bone proper was revealed which was caused by a 2.5-2.8-fold increase of the volume of intercellular fluid in the zone of the affection, leading to circulatory disorders and necrosis. Dehydration of the tissues is accomplished by inflicting numerous percutaneous osteoperforations (NPO) with Kirschner's wire. The osteoperforations are made not at random but in a regular manner through both walls of the bone in two interperpendicular planes. Circulation in the zone of the affection is restored in this case and osteonecrosis in prevented. Conservative methods of treatment of acute hematogenous osteomyelitis were developed according to the stage of its development and were applied in 168 patients whose ages ranged from 20 days to 14 years; in 75% of patients who were admitted in the early stages of AHO the disease took and abrupt course. In patients with neglected forms of AHO three-fourfold infliction of NPO in the subacute stage produced a stimulating effect on reparative regeneration in the zones of osteonecrosis and the forming sequestra.

[Choice of a method of draining the mediastinum in children with anterior purulent mediastinitis]. / Vybor metoda drenirovaniia sredosteniia u detei s perednim gnoinym mediastinitom.

The authors make an analysis of results of the treatment of 10 children of early age with anterior purulent mediastinitis. Indications for different methods of drainage of mediastinum are discussed in the restricted and extended processes. The method of retrosternal drainage of mediastinum in its total length is described for extended purulent mediastinitis. The proposed technique in combination with medication and infusion therapy allowed to avoid lethal outcomes.