Dermo-cosmetic spray containing Rhealba oat plantlets and Uncaria tomentosa extract in patients with mild-to-moderate cutaneous pain.

BACKGROUND: Chronic cutaneous pain has a substantial negative impact on quality of life (QoL). Dermo-cosmetics can support therapies for treatment of chronic skin diseases, providing symptomatic relief from chronic cutaneous pain and improved QoL. OBJECTIVES: To assess the global tolerance and efficacy of a dermo-cosmetic spray containing Rhealba® Oat Plantlet and Uncaria tomentosa extracts in reducing cutaneous pain when used as a monotherapy or in association with drug or dermo-cosmetic treatments in patients with an underlying skin pathology. METHODS: Patients aged ≥1 month with a cutaneous pain level ≥3 and an underlying skin pathology were provided with the spray to use up to six times daily for 6-8 weeks. Immediate effect on cutaneous pain and patient satisfaction were assessed after the first application. Global efficacy and tolerance, reduction in symptoms, improvement in QoL, pain reduction and patient overall satisfaction were assessed after 6-8 weeks. RESULTS: Immediately after the first application, significant reductions in cutaneous pain were observed across all age groups (P < 0.0001), with 94% of patients reporting a reduction in pain. After 6-8 weeks, global tolerance was rated 'very good' or 'good' for 97% of patients, and the spray was efficacious in 95% of patients. Patient satisfaction with the efficacy of the spray was 95%. QoL scores improved in 86% and 94% of patients aged ≥12 and <12 years, respectively. Findings were similar across underlying pathology and therapy types (monotherapy or in association with another therapy). CONCLUSIONS: The spray was well-tolerated and efficacious in providing symptom relief in patients with mild-to-moderate cutaneous pain, irrespective of the underlying pathology or therapy type.

Metástasis cutáneas craneocervicales de un carcinoma papilar de tiroides variedad folicular / Cutaneous metastases on the head and neck from a papillary thyroid carcinoma, follicular variant

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Cicatriz hipértrofica y queloide después de la aplicación de imiquimod 5% crema. A propósito de 2 casos / Utilidad de la ecografía cutánea en el diagnóstico de las complicaciones por materiales de relleno The Utility of Skin Ultrasound for the Diagnosis of Complications of Tissue Filler Materials

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Deducing the molecular properties of zwitterionic, protonated, deprotonated, and double-deprotonated forms of L-cysteine from vibrational spectroscopy (IR, Raman, VCD) and quantum chemical calculations.

The behavior of L-cysteine (C3H7NO2S, (2R)-2-amino-3-sulfanylpropanoic acid) in water at different pH values was analyzed both experimentally and theoretically. The behavior was studied at pH values of 5.21 (at this pH, L-cysteine is a zwitterionic species), 1.00 (protonated species), 8.84 (monodeprotonated species), and 13.00 (dideprotonated species). We carried out a vibrational study using nonchiroptical (IR-Raman) and chiroptical (VCD) techniques complemented by quantum chemical calculations. We adopted a dual strategy, as follows. (i) The hybrid density functionals B3LYP and M062X and the ab initio MP2 method were employed, with the same 6-311++G (d,p) basis set, in order to characterize the relative energies and structures of an extensive set of conformers of L-cysteine. The presence of water was included by utilizing the IEF-PCM implicit solvation model. (ii) The vibrational analysis was made using a chirality-sensitive using a chirality-sensitive technique (VCD) and chirality-insensitive techniques (IR, including MIR and FIR, and Raman), especially in aqueous solution. The results obtained theoretically and experimentally were compared in order to deduce the most stable structures at each pH. Moreover, for the first time, the monodeprotonated anion of L-cysteine was detected in aqueous solution by means of IR, Raman and vibrational circular dichroism (VCD). Finally, analysis of the low-frequency region using the IR and Raman techniques was shown to be a very important way to understanding the conformational preference of the zwitterionic species.

[Peripartum myocardiopathy. A case report, diagnostic and therapeutic considerations]. / Miocardiopatía periparto. Informe de un caso, consideraciones diagnósticas y terapéuticas.

A case of periobstetric cardiomyopathy is presented, it was identified at 32 weeks, because of congestive cardiac failure, the obstetric event was resolved by cesarean section due to low fetal reserve, clinical and hemodynamical criteria for diagnosis are reviewed and also therapeutic alternatives are discussed.

Degradation of ampicillin in the presence of cadmium (II) ions.

Cadmium (II) ion-catalyzed degradation of ampicillin in methanol at 20 degrees C has been studied. It has been observed that the rate values tend to saturate when the concentration of ampicillin or the metal ion is increased. The results obtained in the present study suggest that ampicillin degradation occurs through the formation of a 1:1 (SM) and 2:1 (S(2)M) ampicillin-metal complexes. These complexes decompose giving a single product (absorption maximum at 285 nm; ((p)=1.82x10(4) l mol(-1) cm(-1)) that has been isolated and identified (Cd(II) (L(2-))(2) (H(2)O)(4) Na(2)). The appearance of this product reflects a first order reaction with respect to the 1:1 complex, with a rate constant of 3.87x10(-2) min(-1) and the existence of an equilibrium between the 1:1 and 2:1 initial complexes. The equilibrium constant value, calculated from kinetic data, is 1.7x10(3) l mol(-1).

Reaction of sodium amoxicillin with Cu(II) ion in a methanolic medium.

The present article considers several physicochemical aspects of the complexation reaction of sodium amoxicillin and Cu(II) ion in a methanolic medium. Analysis of spectrophotometric data demonstrated the formation of two complex species with amoxicillin:Cu(II) ion mole ratios of 1:1 and 2:1. Stability constants (beta) and molar absorptivities at 610 nm (epsilon) of the complexes (20 degrees C) in methanol were calculated simultaneously by a computer program on the basis of absorbance data obtained at 610 nm. The values thus calculated for the 1:1 complex were as follows: log beta 1 = 5.48 +/- 0.21 L.mol-1, epsilon 1 = 70 +/- 2 L.mol-1.cm-1. The values for the 2:1 complex were as follows: log beta 2 = 8.98 +/- 0.17 L2.mol-2 and epsilon 2 = 138 +/- 4 L.mol-1.cm-1. The amoxicillin:Cu(II) ion complexes were quite stable over time.