OpenModelica-based virtual simulator for the cardiovascular and respiratory physiology of a neonate.

There is a lack of medical simulation tools that can be understood and used, at the same time, by researchers, teachers, clinicians and students. Regarding this issue, in this work we report a virtual simulator (developed in OpenModelica) that allow to experiment with the fundamental variables of the cardiovascular and respiratory system of a neonate. We extended a long-tested lumped parameter model that represents the cardiovascular and respiratory physiology of a neonate. From this model, we implemented a physiological simulator using Modelica. The fidelity and versatility of the reported simulator were evaluated by simulating seven physiological scenarios: two of them representing a healthy infant (newborn and 6-months old) and five representing newborns affected by different heart diseases. The simulator properly and consistently represented the quantitative and qualitative behaviour of the seven physiological scenarios when compared with existing clinical data. Results allow us to consider the simulator reported here as a reliable tool for researching, training and learning. The advanced modelling features of Modelica and the friendly graphical user interface of OpenModelica make the simulator suitable to be used by a broad community of users. Furthermore, it can be easily extended to simulate many clinical scenarios.

First Colombian multicentric newborn screening for congenital toxoplasmosis.

AIMS: To determine the incidence of congenital toxoplasmosis in Colombian newborns from 19 hospital or maternal child health services from seven different cities of five natural geographic regions (Caribbean, Central, Andean, Amazonia and Eastern). MATERIALS AND METHODS: We collected 15,333 samples from umbilical cord blood between the period of March 2009 to May 2010 in 19 different hospitals and maternal-child health services from seven different cities. We applied an IgM ELISA assay (Vircell, Spain) to determine the frequency of IgM anti Toxoplasma. The results in blood cord samples were confirmed either by western blot and repeated ELISA IgM assay. In a sub-sample of 1,613 children that were negative by the anti-Toxoplasma IgM assay, the frequency of specific anti-Toxoplasma IgA by the ISAGA assay was determined. All children with positive samples by IgM, IgA, clinical diagnosis or treatment during pregnancy were recalled for confirmatory tests after day 10 of life. RESULTS: 61 positive samples for specific IgM (0.39%) and 9 positives for IgA (0.5%) were found. 143 questionnaires were positive for a clinical diagnosis or treatment for toxoplasmosis during pregnancy. 109 out of the 218 children that had some of the criteria for postnatal confirmatory tests were followed. Congenital toxoplasmosis infection was confirmed in 15 children: 7 were symptomatic, and three of them died before the first month of life (20% of lethality). A significant correlation was found between a high incidence of markers for congenital toxoplasmosis and higher mean annual rainfall for the city. CONCLUSIONS: Incidence for congenital toxoplasmosis is significantly different between hospitals or maternal child health services from different cities in Colombia. Mean annual rainfall was correlated with incidence of congenital toxoplasmosis.