RESUMO
The role of antibiotics in the therapeutical result and in the postoperative complications was studied after 557 thoracic operations. It was found that antibiotics have no decisive role in the therapeutic result and there was no difference in the incidence of wound infections between the groups treated with different antibiotics. The principles and practice of treatment of would infections and pyothorax are discussed in detail. No relationship was found between the incidence of postoperative respiratory complications and the various drug treatments. Prevention and treatment of postoperative respiratory complications are discussed. The length of the febrile period was independent of the antibiotics applied. Their time of application, the problem of changing drugs and their side-effects after thoracic operations are analyzed.
Assuntos
Antibacterianos/uso terapêutico , Cuidados Pós-Operatórios , Complicações Pós-Operatórias/tratamento farmacológico , Cirurgia Torácica/efeitos adversos , Antibacterianos/administração & dosagem , Febre/tratamento farmacológico , Humanos , Doenças Respiratórias/tratamento farmacológico , Infecção da Ferida Cirúrgica/tratamento farmacológico , Cicatrização/efeitos dos fármacosRESUMO
This report is concerned with a patient successfully operated for Holt-Oram syndrome. The disorder is inherited dominantly with complete penetrance and variable expressivity. It is pointed out that in cases of congenital heart disease familial cumulation must be borne in mind which can easily be verified by pedigree investigation. After demonstrating autosomal dominant inheritance, suitable inferences must be drawn for genetic counseling. Attention is drawn to the heart-surgical significance of the rhythm disorders so often associated with the syndrome.
Assuntos
Deformidades Congênitas da Mão , Cardiopatias Congênitas/genética , Anormalidades Múltiplas/genética , Anormalidades Múltiplas/cirurgia , Adolescente , Feminino , Cardiopatias Congênitas/cirurgia , Humanos , Linhagem , SíndromeRESUMO
Authors describe the distribution and antibiogram of 185 microorganism strains cultured from thoracic surgical diseases. Gentamycin has been efficacious in the great majority of Gram negative pathoorganisms even in cases where other antibiotics were ineffective. In 14 cases they determined gentamycin concentration of serum and removed lung tissue between the 30th and 120th minutes after intramuscular application of 80 mg gentamycin. The serum level was 2.2 to 6.4 mcg/ml, 4.6 mcg/ml in average, the lung tissue level 0.4 to 3.0 mcg/g, 1.3 mcg/g on an average, the distribution quoteint 30 to 70%, 37% in average. 17 patients were locally treated by gentamycin because of thoracic surgical infections. In acute cases the results have been good, in chronic cases improvement has been achieved.
