[Anisakiasis of the stomach--a case report from Germany]. / Anisakiasis des Magens--ein Fallbericht aus Deutschland.

Anisakiasis or "herring worm disease" is one of the most important parasitic diseases of the gastrointestinal tract in Japan. In 1988 Lorenz and Warzok published 8 cases of intestinal anisakiasis in Eastern Germany. In 1988 Spehn et al. reported a case of gastric anisakiasis in an AIDS patient. Here, we describe a case of gastric anisakiasis in Germany with an impressive serious clinical course. The symptoms--acute abdominal cramps, severe chest pain, diarrhoea, sub-febrile temperatures and leucocytosis--followed 4 h after consumption of raw herring, which was homemade pickled in vinegar. The conventional and the endoscopic ultrasonography showed a thickened gastric wall made of mainly thickened submucosa. The larvae of Anisakis in the gastric mucosa were found and extracted endoscopically. Acute and severe abdominal pain after eating raw fish is an indication for early gastroscopy. The endoscopical extraction of possible larvae is the only effective therapy, as anthelmintics against nematodes (mebendazole, albendazole, thiabendazole) are ineffective.

[Short term cultivation of Plasmodium for the determination of chloroquine resistance]. / Kurzzeitkultivierung von Plasmodien zur Bestimmung der Chloroquinresistenz.

The in-vivo-test of Plasmodium drug resistance is one of the essential basic controls, assisting therapeutic measures in tropical malaria. An initial in-vitro-check up of drugs provided for antimalarial therapy is another useful help to the clinician. Even when manufactured WHO test kits are not available, the analysis of drug resistance can be performed under simple working conditions. Its application is demonstrated in a patients history.

[Immunofluorescence serologic findings in schistosomiasis. Methodologic aspects]. / Immunfluoreszenzserologische Befunde bei Schistosomiasis.--Methodische Aspekte.

In 101 Africans with schistosomiasis the IFAT showed sensitivity in 71%, in which cases frozen sections of adult Mansoni-bilharzias were used as antigen. An observation of the sensitivity of the IFAT separated according to the species of parasites for the affection with S. mansoni resulted in a by 23% higher sensitivity in contrast to the S. haematobium affection. In double infestation the sensitivity was 77%. Using a soluble S. mansoni antigen the ELISA had a sensitivity of 53% in the affection by S. mansoni and of 33% in the affection by S. haematobium. One month after the treatment the sensitivity of the two methods at first increased (IFAT by 19%, ELISA by 21%) and during the further observation decreased to the initial values 6 months after the therapy and after 1 year still further diminished. In 42 Europeans free of helminths the specificity of the IFAT was 93% and in 52 Africans free of schistosomes from regions with schistosomiasis endemy 88%. The accuracy of the IFAT for the qualitative statement positive and negative was greatest in the serum dilution of 1:26.

Peculiarities of Mekong schistosomiasis with particular attention to the People's Democratic Republic of Laos.

The authors examined 10 children with clinical symptoms suggestive of intestinal or hepatolienal schistosomiasis. All the children were from the endemic focus in Laos. We found eggs of schistosomes that were smaller and rounder (60.95 X 51.55 microns) than those from a southern Chinese strain of S. japonicum (62.64 X 73.49 microns). There were no Oncomelania species found among the snails in this endemic area. These observations confirm those reports in the literature that assert a new species for S. mekongi based upon epidemiological, biological and morphological characteristics.

[Clinical aspects and therapy of schistosomiasis]. / Klinik und Therapie der Schistosomiasis.

Among 810 parasitologically examined persons (1981) 277 (34%) showed positive findings. The high percentage of parasitisation in foreigners (86%) is to be explained by the in most cases aimed transfer of these patients (215 of the 810 persons). Affection with Schistosoma was recognized in 51 patients at the age of 17-47 years (means = 21.86), without Africans, and stood in the 3rd place of the distribution of frequency of the heterogeneous parasitoses. 49 of these patients came from Mozambique, 1 from Namibia and 1 from Zambia. In 51% S. haematobium was diagnosed, in 22% S. mansoni and in 27% a double infestation with the two forms of parasites. While 80% of the patients with affection of S. haematobium showed clinical symptoms (macrohaematuria, cystitis complaints), there were only 44% among the S. mansoni group. 47 patients were treated with Niridazole (Ambilhar, 25 mg/kg, 5-7 days), 2 patients with Praziquantel (Biltricide, 40 mg/kg, 1 day) and 2 other patients with Praziquantel after unsuccessful Niridazole therapy. Follow-up examinations were performed after 1, 3, 6 and 12 months. In 17% of the patients treated with Niridazole the primary treatment did not lead to cure; side effects (abdominal pain, nausea, vertigo) were observed in 55%. Praziquantel was tolerated very well. During a control period of 1 year living eggs of Schistosoma were no more proved.

[Human infestation with liver flukes]. / Uber den Befall des Menschen mit Leberegeln

Casuistic reports supplement parasitological and epidemiological references to the affection of man with Fasciola hepatica, Clonorchis sinensis and Opisthorchis felineus. Due to the increase of the tourist traffic must be reckoned with a more frequent appearance of these parasitoses little known in Middle Europe.