1.
RSC Chem Biol
; 3(4): 426-430, 2022 Apr 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35441139
RESUMO
This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis of CSY-protected peptides, and CSY cleavage in partially folded or aggregation-prone peptides.