Assuntos
Paralisia Cerebral/genética , Corioamnionite/genética , Interleucina-6/genética , Complicações na Gravidez/genética , Adulto , Feminino , Predisposição Genética para Doença , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Deficiência Intelectual/complicações , Deficiência Intelectual/genética , Leucomalácia Periventricular/complicações , Leucomalácia Periventricular/genética , Polimorfismo de Nucleotídeo Único , Gravidez , Nascimento Prematuro/genéticaRESUMO
BACKGROUND: Transient periventricular echodensities (PVE) in preterm infants affect neurodevelopmental outcome. OBJECTIVE: To correlate the duration and grading of PVE with neurodevelopmental outcome. MATERIALS AND METHODS: A retrospective, single-centre cohort study of infants with PVE diagnosed by ultrasonography from 1995 to 2000 with blinded grading and recognition of duration of PVE. RESULTS: A total of 72 infants (median gestational age 32 weeks, median birth weight 1,668 g) were diagnosed as having PVE. Minor neurological abnormalities were diagnosed in seven (10%), cerebral palsy in six (8%), developmental delay in seven (10%), and mild mental retardation in two (3%) of the infants. Differences regarding adverse outcome were not significant between infants with severity grade 1 compared to severity grade 2 (16% and 22%, respectively). There was a significant increase in adverse neurodevelopmental outcome with increasing duration of PVE. Of 33 infants with duration of PVE<7 days, 1 (3%) had an adverse neurodevelopmental outcome, compared to 6 (24%) of 25 infants with a duration of PVE of 7-14 days, and 6 (43%) of 14 infants with a duration of PVE>14 days (P<0.002, RR 7.920, 95% CI 1.017-61.661; P<0.001, RR 14.143, 95% CI 1.871-106.895, respectively). CONCLUSION: The duration, but not the grading, of transient PVE was significantly correlated with neurodevelopmental outcome.
Assuntos
Ventrículos Cerebrais/anormalidades , Ventrículos Cerebrais/diagnóstico por imagem , Ecoencefalografia , Doenças do Prematuro/diagnóstico por imagem , Leucomalácia Periventricular/diagnóstico por imagem , Paralisia Cerebral/diagnóstico por imagem , Paralisia Cerebral/etiologia , Estudos de Coortes , Deficiências do Desenvolvimento/diagnóstico por imagem , Deficiências do Desenvolvimento/etiologia , Feminino , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Deficiência Intelectual/diagnóstico por imagem , Deficiência Intelectual/etiologia , Leucomalácia Periventricular/complicações , Masculino , Gravidez , Prognóstico , Estudos RetrospectivosRESUMO
We report a case of congenital bilateral chylothorax, complicated by pulmonary eosinophilic vasculitis and transient eosinophilia. Excluding all known forms of eosinophilic pulmonary disease either histologically or clinically, possible mechanisms of its etiology are discussed. Treatment with corticosteroids was successful, and after a prolonged clinical course the patient recovered by age 2 years.
