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1.
Pak J Biol Sci ; 24(3): 366-373, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34486322

RESUMO

<b>Background and Objective:</b> Vitamin A Deficiency (VAD) is a critical public health problem that affects the health of kids worldwide and may induce anemia and oxidative stress. The current study aimed to pre-clinically assess the effect of a cupcake, prepared to be served for primary school children, on vitamin A deficiency and related anemia and oxidative stress in rats. <b>Materials and Methods:</b> Flour of flash orange sweet potatoes, as a rich source of pro-vitamin A, was used to prepare the cupcake. The chemical composition, amino acids and sensory evaluation of the cupcake were done. The biological evaluation was carried out using 18 weaning rats in three groups (control group, vitamin A-deficient group and vitamin A-deficient group fed on a diet fortified with 20% of the prepared cupcake for two months). <b>Results:</b> The results indicated the high value of vitamin A in the prepared cupcake. Excellent sensory characteristics were noticed. Feeding on the VDA diet fortified with the prepared cupcake suppressed the reduction in Retinol-Binding Protein (RBP), hemoglobin and iron. Total Iron Binding Capacity (TIBC) increased in the VAD group. Also, feeding on the prepared cupcake suppressed the reduction in Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) and the elevation of Malondialdehyde (MDA). <b>Conclusion:</b> It can be suggested that the prepared cupcake is promising in preventing of vitamin A deficiency and related anemia and oxidative stress. Thus, the prepared cupcake may be efficient for children to prevent vitamin A deficiency.


Assuntos
Anemia/dietoterapia , Estresse Oxidativo/fisiologia , Deficiência de Vitamina A/dietoterapia , Vitamina A/administração & dosagem , Análise de Variância , Anemia/fisiopatologia , Animais , Suplementos Nutricionais/normas , Suplementos Nutricionais/estatística & dados numéricos , Modelos Animais de Doenças , Hemoglobinas/análise , Estresse Oxidativo/efeitos dos fármacos , Ratos , Ratos Wistar , Vitamina A/uso terapêutico , Deficiência de Vitamina A/fisiopatologia
2.
Pak J Biol Sci ; 21(8): 401-408, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30418002

RESUMO

BACKGROUND AND OBJECTIVE: School children especially in Egypt need a safe meal which is able to meet their daily nutrient needs and ameliorate cognition. So, the current study aimed to evaluate formula prepared as cookies to be served as a meal for primary school children. MATERIALS AND METHODS: Wheat, roasted chickpea, milk protein concentrate, cinnamon and brewer's yeast were used to prepare cookies which have been exposed to sensory, chemical and biological evaluation. Peroxide number, amino acids, vitamins (D, B12, folic acid and E) and minerals (calcium, zinc, iron and selenium) were determined. Twenty four rats of weaning age were used, 12 rats to estimate the true protein digestibility and 12 rats to estimate the protein efficiency ratio and the effect of feeding on cookies (28 days) on hemoglobin, glucose, total protein, liver and kidney functions and antioxidant status. RESULTS: Palatability and acceptability of cookies were insured via the sensory evaluation results. The value of peroxide number indicated that there is no possibility of rancidity during the storage. The cookies showed high contents of protein (14.88%), fat (16.83%) and carbohydrate (55.1%). Also cookies showed acceptable levels of amino acids, minerals and vitamins that meet a large amount of daily requirements of children. Results of the animal experiment declared the complete safety of the cookies and high nutritional and biological quality. CONCLUSION: Cookies can serve as a meal for the governmental school children to provide them with their needs from nutrients that reducing hunger and improving health benefits and scholastic achievement.


Assuntos
Alimentos Formulados/análise , Alimento Funcional/análise , Aminoácidos/química , Animais , Antioxidantes/química , Criança , Gorduras na Dieta/síntese química , Egito , Ácido Fólico/química , Humanos , Masculino , Refeições , Minerais/química , Valor Nutritivo/fisiologia , Proteínas/química , Ratos , Instituições Acadêmicas , Triticum/química , Vitaminas/química
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