Identification of biomarkers for the diagnosis and treatment of primary colorectal cancer based on microarray technology.

BACKGROUND: Primary colorectal cancer (PCRC) is one of the most common malignant tumors in clinic, and is characterized by high heterogeneity occurring between tumors and intracellularly. Therefore, this study aimed to explore potential gene targets for the diagnosis and treatment of PCRC via bioinformatic technology. METHODS: Gene Expression Omnibus (GEO) was used to download the data used in this study. Differently expressed genes (DEGs) were identified with GEO2R, and the gene set enrichment analysis (GSEA) was implemented for enrichment analysis. Then, the researchers constructed a protein-protein interaction (PPI) network, a significant module, and a hub genes network. RESULTS: The GSE81558 dataset was downloaded, and a total of 97 DEGs were found. There were 23 up-regulated DEGs and 74 down-regulated DEGs in the PCRC samples, compared with the control group. The PPI network included a total of 42 nodes and 63 edges. One module network consisted of 11 nodes and 25 edges. Another module network consisted of 4 nodes and 6 edges. The hub genes network was created by cytoHubba using GCG, GUCA2B, CLCA4, ZG16, TMIGD1, GUCA2A, CHGA, PYY, SST, and MS4A12. CONCLUSIONS: Ten hub genes were found from the genomic samples of patients with PCRC and normal controls by bioinformatics analysis. The hub genes might provide novel ideas and evidence for the diagnosis and targeted therapy of PCRC.

Remote safety monitoring for elderly persons based on omni-vision analysis.

Remote monitoring service for elderly persons is important as the aged populations in most developed countries continue growing. To monitor the safety and health of the elderly population, we propose a novel omni-directional vision sensor based system, which can detect and track object motion, recognize human posture, and analyze human behavior automatically. In this work, we have made the following contributions: (1) we develop a remote safety monitoring system which can provide real-time and automatic health care for the elderly persons and (2) we design a novel motion history or energy images based algorithm for motion object tracking. Our system can accurately and efficiently collect, analyze, and transfer elderly activity information and provide health care in real-time. Experimental results show that our technique can improve the data analysis efficiency by 58.5% for object tracking. Moreover, for the human posture recognition application, the success rate can reach 98.6% on average.

Microporous pillared paddle-wheel frameworks based on mixed-ligand coordination of zinc ions.

The reaction of Zn(NO3)2 x 6H2O, various dicarboxylic acids, and either 4,4'-bipyridine or N,N'-di(4-pyridyl)-1,4,5,8-naphthalenetetracarboxydiimide produces a family of anisotropic, mixed-ligand, open-framework compounds featuring paddle-wheel-type coordination of Zn(II) pairs in two dimensions and pyridyl ligand pillaring in the third. Despite 2-fold interpenetration, the compounds contain channels of molecular dimensions and several are permanently microporous, displaying high internal surface areas.

Observation of an octameric water cluster containing a book-shaped hexamer in a 4f-3d complex.

An octameric water cluster consisting of a book-shaped water hexamer and two dangling water molecules has been observed in a 4f-3d ionic pair complex [Y(dpdo)2(H2O)4][Co(CN)6].4H2O.

Assembly of hydrogen bonded diamondoid networks based on synthetic metal-organic tetrahedral nodes.

Reaction of Mn(ClO4)2 or Co(PF6)2 with 4,4'-dipyridine-dioxide (dpdo) produced novel molecular species [M(dpdo)4(H2O)2]2+, which hold a tetrahedral configuration notwithstanding their octahedral environment around the metal centers. The tetrahedral moieties are further assembled through hydrogen bonds between peripheral NO ends of dpdo ligands and coordinated water molecules, giving rise to 3D diamondoid networks.

Cyclic water pentamer in a tape-like structure.

A novel water tape consisting of fused cyclic water pentamers has been observed in a supramolecular compound.

Symmetry induced supramolecular assembly of a resorcinarene trimeric molecular box.

A novel trimeric resorcinarene molecular box is induced during hydrothermal synthesis by use of the 3-fold symmetric tripyridyl triazine linker molecule.

Structure and photoluminescence of a benzil nanocolumn in a C-methylcalix[4]resorcinarene-based framework.

A new framework based on C-methylcalix[4]resorcinarene and the flexible nonconjugated spacer 1,4-bis(imidazol-1yl-methyl)benzene encloses a large one-dimensional channel, containing benzil nanocolumns. Unlike in a previously reported series of benzil-containing supramolecular solids with conjugated linker molecules, benzil luminescence is observed, but the lifetime of 580 ns at 77 K is considerably shorter than the 145 micros reported for neat benzil at room temperature.

Multiple conformations of benzil in resorcinarene-based supramolecular host matrixes.

Six supramolecular complexes incorporating benzil as a guest, CMCR*bipy*benzil (alpha) 1 (CMCR = C-methylcalix[4]resorcinarene), CMCR*bipy*benzil (beta) 2, CMCR*2bpe*benzil*ethanol 3 (bpe = trans-1,4-bis(pyridyl)ethylene), CMCR*2bpe*benzil*2H2O 4, CMCR.2bpeh*benzil*ethanol 5 (bpeh = bis-(1-pyridin-4-yl-ethylidene)-hydrazine), and CECR*2bpe.benzil 6 (CECR = C-ethylcalix[4]resorcinarene), have been synthesized by hydrothermal and conventional methods and characterized by X-ray diffraction. Resorcinarene adopts a boat conformation in 1-4 and a bowl conformation in 5 and 6. Compounds 1-4 show a brick-wall-like framework, in which two benzil molecules are incorporated. For 5, bpeh spacers link CMCR molecules to give a one-dimensional wavelike polymer in which one benzil guest is embedded within the polymer cavity. Complex 6 forms a carcerand-like capsule in which two benzil guests are encapsulated. The O=C-C=O torsion angles vary from 91.8 to 139.3 degrees and correlate with the length of the central C-C bond. The benzil concentration, which is approximately 6.2 mol/L in the neat crystals, varies between 1.01 and 1.51 mol/L in the structures studied, corresponding to a 6-fold dilution. The benzil molecules are disordered in the larger cavities of 4 and 5. The two benzoyl fragments are almost perpendicular in 3, which has the next largest cavity size when solvent volume is excluded, whereas a nearly trans-coplanar conformation occurs for the cavity with the smallest volume in 6.

Formation of pyrene nano-rods within a supramolecular framework.

The combination of trimesic acid and the tri-dentate linker 1,3,5-tri(4-pyridyl)-2,4,6-triazine leads to the assembly of a bilayer structure, which contains four pyrene molecules per cavity; adjacent tetrameric aggregates within the channels formed by the superimposed layers combine to yield pyrene nano-rods.

The design and synthesis of a non-centric diamond-like network based NH4+ ion.

Two novel acentric hydrogen bonded two-dimensional sheet and three-dimensional 2-fold interpenetrating diamond-like networks have been designed and prepared based on a tetrahedral ammonium node and the O,O'-bifunctional linker molecules dipyridine dioxide (dpdo) and trans-bis(4-pyridyl)ethylene dioxide (bpedo).

Long-range ferromagnetic ordering in two-dimensional coordination polymers Co[N(CN)2]2(L) [L = pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo)] with dual mu- and mu3-[N(CN)2] bridges.

Two novel coordination polymers of Co(II) with dicyanamide (dca) were obtained by the addition of ancillary ligands of pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo) into the Co-dca binary system, respectively. Co[N(CN)(2)](2)(pzdo) (1) crystallizes in the orthorhombic space group of Pnnm (No. 58) with a = 9.4699(5) A, b = 14.9984(3) A, c = 7.4313(7) A, and Z = 4, while Co[N(CN)(2)](2)(mpdo) (2) is in the monoclinic space group C2 (No. 5) with a = 16.5391(4) A, b = 9.6065(2) A, c = 7.5001(2) A, beta = 105.779(1) degrees, and Z = 4. Both complexes contain similar two-dimensional triangular Co-dca layers, which offer rare examples of mixed 1,5-mu- and mu(3)-dca bridging coordination polymers with long-range ferromagnetic ordering below ca. 2.5 K.

Three-fold interpenetrating three-dimensional networks based on C-methylcalix[4]resorcinarene incorporating benzophenone guest molecules.

A new solid based on C-methylcalix[4]resorcinarene and the linker molecule bis(4-pyridylmethylidyne)hydrazine (bpmh) has been prepared, in which brick-wall sheets are linked in the third dimension to give networks with three intersecting perpendicular channels; the networks interpenetrate three-fold, but nevertheless leave cavities capable of including sizable guest molecules.

Transformation of a C-methylcalix[4]resorcinarene-based host-guest complex from a wave-like to a novel triangular brick-wall architecture.

A novel 2D triangular brick-wall framework based on CMCR and bpe with included ruthenocene guest molecules is formed with time by conversion of a 1D wave-like polymer structure with an accompanying bowl-to-boat conformational change of the CMCR molecules.

A novel scoop-shaped conformation of C-methylcalix[4]resorcinarene in a bilayer structure.

A new scoop-shaped conformation of C-methylcalix[4]resorcinarene has been identified; it is a hybrid of the previously observed crown- and flattened cone conformations.

Cyano-Bridged 4f-3d Coordination Polymers with a Unique Two-Dimensional Topological Architecture and Unusual Magnetic Behavior.

Rings of 24 atoms form part of the two-dimensional structure of the novel compounds [NdM(bpym)(H2 O)4 (CN)6 ]⋅3 H2 O (M = Fe (1), Co (2); bpym = 2,2'-bipyrimidine). These compounds are the first two-dimensional cyano-bridged species containing lanthanide and transition metal centers. The structures and magnetic properties are investigated.