Insights into AIE materials: A focus on biomedical applications of fluorescence.

Aggregation-induced emission (AIE) molecules have garnered considerable interest since its first appearance in 2001. Recent studies on AIE materials in biological and medical areas have demonstrated that they show their promise as biomaterials for bioimaging and other biomedical applications. Benefiting from significant advantages of their high sensitivity, excellent photostability, and good biocompatibility, AIE-based materials provide dramatically improved analytical capacities for in vivo detection and demonstration of vital biological processes. Herein, we introduce the development history of AIE molecules and recent progress in areas of biotesting and bioimaging. Additionally, this review also offers an outlook for the potential applications of versatile AIE materials for tracing and treating pathological tissues, including overcoming challenges and feasible solutions.

An Overview of Extracellular Matrix-Based Bioinks for 3D Bioprinting.

As a microenvironment where cells reside, the extracellular matrix (ECM) has a complex network structure and appropriate mechanical properties to provide structural and biochemical support for the surrounding cells. In tissue engineering, the ECM and its derivatives can mitigate foreign body responses by presenting ECM molecules at the interface between materials and tissues. With the widespread application of three-dimensional (3D) bioprinting, the use of the ECM and its derivative bioinks for 3D bioprinting to replicate biomimetic and complex tissue structures has become an innovative and successful strategy in medical fields. In this review, we summarize the significance and recent progress of ECM-based biomaterials in 3D bioprinting. Then, we discuss the most relevant applications of ECM-based biomaterials in 3D bioprinting, such as tissue regeneration and cancer research. Furthermore, we present the status of ECM-based biomaterials in current research and discuss future development prospects.

Mechanical and medical imaging properties of 3D-printed materials as tissue equivalent materials.

Three materials of polylactic acid (PLA), polyamide 12 (PA12), and light curing resin (LCR) were used to construct phantom using 3D printing technology. The mechanical and medical imaging properties of the three materials, such as elastic modulus, density, effective atomic number, X-ray attenuation coefficient, computed tomography (CT) number, and acoustic properties, were investigated. The results showed that the elastic modulus for PLA was 1.98 × 103  MPa, for PA12 was 848 MPa, for LCR was 1.18×103  MPa, and that of three materials was close to some bones. In the range of 40∼120 kV, the X-ray attenuation coefficient of three materials decreased with increasing tube voltage. The CT number for PLA, PA12, and LCR was 144, -88, and 312 Hounsfield units at 120 kV tube voltage, respectively. The density and the effective atomic number product (ρ*Zeff ) were computed from three materials and decreased in the order of LCR, PLA, and PA12. The acoustic properties of materials were also studied. The speeds of sound of three materials were similar with those of some soft tissues.

Characterization and sources of volatile organic compounds (VOCs) and their related changes during ozone pollution days in 2016 in Beijing, China.

Concentrations of 99 volatile organic compounds (VOCs) were continuously measured online at an urban site in Beijing, China, in January, April, July, and October 2016. Characterization and sources of VOCs and their related changes during days with heavy ozone (O3) pollution were analysed. The total observed concentration of VOCs (TVOCs) was 44.0 ± 28.9 ppbv. The VOC pollution level has decreased in Beijing but remains higher than in other Chinese cities. Alkanes comprised the highest proportion among seven major sampled VOC groups. The concentrations and sources of ambient VOCs showed obvious temporal variations. Six emission sources were identified by the positive matrix factorization (PMF), including biomass burning, coal combustion, gasoline vehicles, diesel vehicles, solvent usage, and biogenic + secondary emissions. The combustion source was the key control factor for VOC reduction in Beijing. From the potential source contribution function (PSCF) and concentration-weighted trajectory (CWT) model, Beijing, Tianjin, Hebei, Shanxi, Inner Mongolia, Shandong, and Henan were identified as major potential source regions of ambient VOCs. O3 formation was sensitive to VOCs in Beijing according to the VOC/NOx ratio (ppbC/ppbv, 8:1 threshold). High- and low-O3 days in July were identified, and high O3 levels were due to both enhanced VOC emission levels and meteorological conditions favourable to the production of O3. These findings provide evidence that the fuel combustion and regional transport have a great impact on concentrations and sources of VOCs in urban Beijing.

Synthesis and characterization of an octaimidazolium-based polyhedral oligomeric silsesquioxanes ionic liquid by an ion-exchange reaction.

Preparation of POSS-min-DS, an octaimidazolium-based polyhedral oligomeric silsesquioxanes (POSS) room temperature ionic liquid, by an ion-exchange reaction between POSS and sodium dodecyl sulfate was reported. Octaimidazolium-based POSS was synthesized with more than 98% yield within 3 h. POSS-min-DS and octaimidazolium-based POSS were confirmed by (1)H, (13)C, and (29)Si NMR, FT-IR and elemental analysis.