MicroRNA­1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl­terminal hydrolase CYLD expression.

Previous studies have demonstrated that microRNAs (miRs) are important regulators involved in various cancers, including human glioblastoma (GBM). However, the underlying mechanism of miR­1288 remains poorly understood, and its role in GBM has not been reported. The present study confirmed that miR­1288 expression was markedly upregulated in GBM. Ectopic expression of miR­1288 promoted the prolife-ration, colony formation and anchorage­independent growth of GBM cells. Bioinformatics analysis coupled with western blotting and luciferase report assays also indicated that miR­1288 promoted cell proliferation of GBM by targeting ubiquitin carboxyl­terminal hydrolase (CYLD). Knockdown of CYLD expression reversed the cell proliferation promotion by miR­1288­in in GBM. These results suggest that the miR­1288/CYLD axis may represent a potential therapeutic target for the treatment of GBM.