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1.
Zhonghua Yi Xue Za Zhi ; 103(13): 991-998, 2023 Apr 04.
Artigo em Chinês | MEDLINE | ID: mdl-36990715

RESUMO

Objective: To analyze whole brain structural volume asymmetry in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) using automated brain segmentation technology, and to investigate the application value of this technology in the diagnosis of TLE-HS and the performance in determining the location the lateralization of epileptogenic focus. Methods: Twenty-eight patients with TLE-HS were enrolled in the First Affiliated Hospital of Zhengzhou University from April 2019 to October 2020, including 13 females and 15 males, aged ranged from 18 to 63 (30±12) years, and these patients were divided two group according to the epilepsy lateralization, left TLE-HS(LTLE-HS) group (n=11), right TLE-HS(RTLE-HS) group (n=17) and 28 normal controls [aged ranged from 18 to 49 (29±10) years]. All of these subjects underwent three-dimensional T1 weighted image (3D T1WI). The differences of brain structure and volumes in LTLE-HS, RTLE-HS and normal controls group were retrospectively analyzed, and Pearson's correlation coefficient was used to evaluate the left and right volume correlations, and effect size was used for evaluating the differences in left and right volume averages. The asymmetry index (AI) of the left and right lateral volumes in each group was also calculated and compared among the three groups. Results: Standard volumes of all structures within the brain were asymmetric in the normal controls, LTLE-HS, and RTLE-HS groups, with smaller volumes of ipsilateral hippocampus than contralateral hippocampus in both the LTLE-HS and RTLE-HS groups(0.20%±0.03% vs 0.24%±0.02%,0.21%±0.03% vs 0.25%±0.02% respectively;both P<0.001), and smaller volumes of gray and white matter of the ipsilateral temporal lobe than contralateral in the LTLE-HS group(4.41%±0.38% vs 5.01%±0.43%,1.83%±0.22 % vs 2.22%±0.14%;both P<0.001). There was a moderate to strong linear correlation (0.553

Assuntos
Epilepsia do Lobo Temporal , Esclerose Hipocampal , Masculino , Feminino , Humanos , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Epilepsia do Lobo Temporal/diagnóstico , Epilepsia do Lobo Temporal/cirurgia , Estudos Retrospectivos , Lobo Temporal , Encéfalo
3.
Zhonghua Zhong Liu Za Zhi ; 16(3): 177-80, 1994 May.
Artigo em Chinês | MEDLINE | ID: mdl-7956693

RESUMO

Cellular immunity was assayed in 58 esophageal cancer patients with family history of esophageal cancer, 23 patients' first degree relative, 20 esophageal patients with family history of other malignant tumours. 114 esophageal cancer patients without cancer family history and 30 normal subjects were taken as control. The results showed that skin delayed hypersensitivity(DTH) reaction and lymphocyte response to PHA were significantly lower in patients with cancer family history than those without. The DTH reaction, lymphocyte response to PHA and IL-2, NK activity were also remarkably depressed in their first degree relatives, when compared with normal controls. These results indicate that familial immunodeficiency might be one of factors of familial aggregation of esophageal cancer.


Assuntos
Neoplasias Esofágicas/imunologia , Ativação Linfocitária , Adulto , Suscetibilidade a Doenças/imunologia , Neoplasias Esofágicas/genética , Saúde da Família , Feminino , Humanos , Hipersensibilidade Tardia/imunologia , Imunocompetência , Interleucina-2/farmacologia , Células Matadoras Naturais/imunologia , Linfócitos/imunologia , Masculino
4.
Chin Med J (Engl) ; 104(6): 523-5, 1991 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-1651831

RESUMO

Using alpha-32P-dCTP labelled human papillomavirus type 16 DNA genome probe (cHPV 16 DNA, cloned and identified from a Chinese cervical invasive carcinoma), 3 HPV 16 genomic relative sequences were detected in 6 biopsies of laryngeal carcinoma. The results showed serious HPV infection in laryngeal carcinoma. This indicates that HPV infection may play an important pathogenetic role in cancer development.


Assuntos
Carcinoma/microbiologia , DNA Viral/análise , Neoplasias Laríngeas/microbiologia , Papillomaviridae/isolamento & purificação , Infecções Tumorais por Vírus , Southern Blotting , Sondas de DNA de HPV , Humanos
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