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BACKGROUND: Visual attention span (VAS) refers to the number of visual elements processed simultaneously in a multielement array. Yet, there are mixed findings regarding VAS deficit in developmental dyslexia (DD) across different tasks, stimuli, languages, control groups, and ages. AIM: The present meta-analysis aimed to investigate VAS deficit in DD and factors moderating VAS deficit in DD. METHODS: A meta-analysis based on 32 articles, 54 independent studies, and 4211 subjects was conducted. Effect sizes for each study were calculated and a random-effect model was selected. Task and stimulus types in the VAS task, writing system, orthographic depth, control group type, and age were included as possible moderators. RESULTS: 1) VAS in dyslexic individuals was significantly worse than typically developing individuals; 2) Task-stimulus type (report-verbal/n-back-verbal/n-back-nonverbal), writing system (alphabetic vs. Chinese), and control group type (age matched vs. reading matched) significantly moderated VAS deficit in DD. VAS deficit was more severe in report task with verbal stimuli than in n-back task with verbal and nonverbal stimuli. VAS deficit was more severe in alphabetic language than in Chinese. VAS deficit was more severe when compared with age-matched controls than compared with reading-matched controls. CONCLUSION: VAS deficit is a possible etiology for DD and moderated by task-stimulus type, writing system, and control group type. These findings have important implications for the understanding of DD.
RESUMO
Background: The Trier Social Stress Test (TSST) is one of the most widely used laboratory-based psychological stress paradigms. Previous studies have shown that males have a more robust cortisol response than females in the TSST. However, the effects of sample size, speech topic, and interaction between sex and speech topic on cortisol responses in TSST remain elusive. Our goal was to evaluate these influencing factors in the TSST using salivary cortisol reactivity as an objective measure. Methods: We collected TSST research articles in Web of Science, PubMed, PsycNet, and CNKI. We only included TSST studies that had measures of salivary cortisol both before and after task completion. A total of 65 articles involving 76 sub-studies met our inclusion criteria, with a total of 5171 participants (2040 females and 3131 males). The effects of sample sizes were assessed to determine if results of studies with various sample sizes were stable. We performed multivariate meta-regression to determine the effects of speech topic, sex, and the interaction between sex and speech topic after controlling their confounding effects. Subgroup analysis of sex was conducted to detect inter-group differences. We further evaluated the baseline and peak salivary cortisol concentrations for males and females independently to detect the sources of sex differences. Results: The average effect size (i.e., Cohen's d) of salivary cortisol reactivity was 0.93, 95% CI = 0.82 to 1.04, p < .001. The small studies produced larger variations in the reported effect sizes than the large-sample studies (r = -0.24, p = .041). A sample size of 40 was necessary to provide sufficient statistical power to detect significant changes of salivary cortisol in TSST. Speech topics, sex, and sex-speech topic interaction could predict salivary cortisol responses (F(df1 = 3, df2 = 72) = 11.98, p < .001) and explained 42.68% of the total experimental variation. Sex was the only significant contributing factor (p < .00025) in the regression model. Salivary cortisol responses in males were significantly higher than in females (Q B = 42.89, df = 1, p < .001). Further, significant differences between males and females were detected at baseline (t = -2.03, df = 74, p = .046) and peak (t = -4.96, df = 74, p < .001). Conclusions: The TSST effectively induces stress response as measured by salivary cortisol change. Forty samples is the minimum sample size for detecting the robust salivary cortisol responses. We confirmed that males have more robust salivary cortisol reactivity than females in TSST. Speech topics that we tested did not significantly contribute to differences in salivary cortisol responses. No significant interaction between sex and speech topic on salivary cortisol responses was detected.
RESUMO
Children and adults with autism spectrum disorder (ASD) often present with atypical gaze patterns to others' faces, a finding substantiated throughout the literature. Yet, a quantification of atypical gaze patterns to different facial regions (e.g., eyes versus mouth) in ASD remains controversial. Also few study has investigated how age and culture impacted the pattern of gaze abnormalities in ASD. This research therefore conducted a meta-analysis of eye-tracking studies to evaluate age and culture effect on atypical gaze patterns of face processing in ASD. A total of 75 articles (91 studies) and 4209 individuals (ASD: 2027; controls: 2182) across all age ranges (i.e., childhood through to adulthood) from both Eastern and Western cultures were included in this meta-analysis. Individuals with ASD yielded shorter fixation durations to the eyes than individuals without ASD. Group differences in the time spent fixating on the eyes were not modulated by age, but affected by culture. Effect size in the eastern culture was larger than that in the western culture. In contrast, group differences on time spent looking at the mouth were not significant, but changed with age and modulated by culture. Relative to the neurotypical controls, Western individuals with ASD spent more time looking at the mouth from school age, whereas Eastern individuals with ASD did not gaze longer on mouth until adulthood. These results add to the body of evidence supporting atypical gaze behaviors to eyes in ASD and provide new insights into a potential mouth compensation strategy that develops with age in ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) often show atypical gaze patterns when looking at others' faces compared to neurotypical individuals. This paper examines the role of age and culture on pattern of gaze abnormalities in individuals with ASD. Results show that reduction of gaze on eyes in ASD is stable across all ages and cultures, while increase of gaze on mouth emerges as individuals with ASD get older. The findings provide a developmental insight to the gaze patterns on the autism spectrum across culture.
