A Route for Investigating Psoriasis: From the Perspective of the Pathological Mechanisms and Therapeutic Strategies of Cancer.

Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully elucidated. The core pathological process of psoriasis is epidermal thickening caused by the excessive proliferation of epidermal keratinocytes, which is similar to the key feature of cancer; the malignant proliferation of cancer cells causes tumor enlargement, suggesting that there is a certain degree of commonality between psoriasis and cancer. This article reviews the pathological mechanisms that are common to psoriasis and cancer, including the interaction between cell proliferation and an abnormal immune microenvironment, metabolic reprogramming, and epigenetic reprogramming. In addition, there are common therapeutic agents and drug targets between psoriasis and cancer. Thus, psoriasis and cancer share a common pathological mechanisms-drug targets-therapeutic agents framework. On this basis, it is proposed that investigating psoriasis from a cancer perspective is beneficial to enriching the research strategies related to psoriasis.

Development and application of an environment monitoring system based on IPv6.

The widespread use of the Internet of Things (Iot) makes it possible to connect everything but having enough IP addresses is a fundamental requirement of this paradigm. All previous environmental monitoring systems in China are based on IPv4. In combination with the characteristics and requirements of China's atmospheric environment monitoring system, this paper develops a monitoring system based on IPv6 technology. Users can directly access the monitoring equipment through the IPv6 website to view data and configure operations. This paper first introduces the design and implementation of the software and hardware of the system, then introduces the simplification of IPv6 protocol, the transplantation of IPv6 protocol on ARM and the design and implementation of embedded Web server system. The experimental results show that the developed atmospheric environment monitoring system can realize continuous data acquisition based on IPv6 and provide data-driven support for environmental protection management and decision-making.

Validation of leaf area index measurement system based on wireless sensor network.

Accurate measurement of leaf area index (LAI) is important for agricultural analysis such as the estimation of crop yield, which makes its measurement work important. There are mainly two ways to obtain LAI: ground station measurement and remote sensing satellite monitoring. Recently, reliable progress has been made in long-term automatic LAI observation using wireless sensor network (WSN) technology under certain conditions. We developed and designed an LAI measurement system (LAIS) based on a wireless sensor network to select and improve the appropriate algorithm according to the image collected by the sensor, to get a more realistic leaf area index. The corn LAI was continuously observed from May 30 to July 16, 2015. Research on hardware has been published, this paper focuses on improved system algorithm and data verification. By improving the finite length average algorithm, the data validation results are as follows: (1) The slope of the fitting line between LAIS measurement data and the real value is 0.944, and the root means square error (RMSE) is 0.264 (absolute error ~ 0-0.6), which has high consistency with the real value. (2) The measurement error of LAIS is less than LAI2000, although the result of our measurement method will be higher than the actual value, it is due to the influence of weeds on the ground. (3) LAIS data can be used to support the retrieval of remote sensing products. We find a suitable application situation of our LAIS system data, and get our application value as ground monitoring data by the verification with remote sensing product data, which supports its application and promotion in similar research in the future.

Validation of GPS-Based Monitoring and Remote Sensing of Ice-Shelf and Ice-Sheet Movement Changes.

The north and south poles of the earth (hereinafter referred to as the polar regions) are important components of the earth system. Changes in the material balance and movement of the polar ice shelf reflect the influence of the polar regions on global climate change and are also a response to global climate change. Through a comprehensive investigation of ice-shelf kinematics, with sufficient accuracy, it is possible to obtain ice-shelf elevation, movement-state data, ice-shelf material balance state, and the ice-shelf movement dynamics mechanism. Due to the extremely harsh environment in polar regions, remote sensing is currently widely used. Manual and equipment monitoring methods show insufficient accuracy or discontinuous time series. There is an urgent need to obtain continuous real-time ice-shelf kinematics-related parameters on the ground to verify the reliability of the parameters obtained by satellite remote sensing. These parameters should be combined with remote sensing monitoring to provide data support. In this paper, a monitoring system for the movement of polar ice and shelf ice cover is developed, and it is proposed that various data can be acquired by integrating high-precision GPS (global positioning system) and other sensors. Solutions to the problem of low-temperature power supply in the polar regions, data acquisition and storage strategies, and remote communication methods are proposed. Testing and remote sensing validation verified that the developed acquisition system can fulfill the requirements for monitoring the movement of the polar unmanned ice shelves and ice sheets.

KOH activation of wax gourd-derived carbon materials with high porosity and heteroatom content for aqueous or all-solid-state supercapacitors.

Biomass precursors with natural porous structure and multifarious heteroatoms are desirably sustainable precursors for synthesis of carbon materials for energy and environmental applications. Herein, we reported wax gourd based porous carbons (WGPCs) with developed micro/mesoporous structures via potassium hydroxide (KOH) chemical activation. The optimized material that is denoted as WGPC-4 exhibits high specific surface area (2919 m2 g-1) with oxygen and nitrogen contents of 17.9 at.% and 1.0 at.%, respectively. In a three-electrode system, the WGPC-4 electrode presents high specific capacitance of 333 F g-1 at current density of 1 A g-1. Meanwhile, the assembled symmetrical cell using aqueous electrolyte (0.5 M Na2SO4) has high specific capacitance (167 F g-1 at 1 A g-1), stable cycling characteristics (93% capacitance retaining after 5000 runs) and excellent energy density of 19.2 Wh kg-1. Furthermore, these WGPC-4 electrodes were assembled into an all-solid-state supercapacitor using KOH/polyvinyl alcohol (PVA) gel as solid electrolyte, whose specific capacitance is 258 F g-1 at 1 A g-1, retention at the 2500th run is 87% and energy density is 13.0 Wh kg-1 under a high power density. These materials with excellent structural characteristics are an ideal candidate for high-performance supercapacitors.

Development and Application of an Atmospheric Pollutant Monitoring System Based on LoRa-Part I: Design and Reliability Tests.

At present, as growing importance continues to be attached to atmospheric environmental problems, the demand for real-time monitoring of these problems is constantly increasing. This article describes the development and application of an embedded system for monitoring of atmospheric pollutant concentrations based on LoRa (Long Range) wireless communication technology, which is widely used in the Internet of Things (IoT). The proposed system is realized using a combination of software and hardware and is designed using the concept of modularization. Separation of each function into independent modules allows the system to be developed more quickly and to be applied more stably. In addition, by combining the requirements of the remote atmospheric pollutant concentration monitoring platform with the specific requirements for the intended application environment, the system demonstrates its significance for practical applications. In addition, the actual application data also verifies the sound application prospects of the proposed system.