1.
Amino Acids
; 54(11): 1519-1526, 2022 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36229670
RESUMO
The present study describes an efficient access to enantioenriched pyrimidines' derivatives from readily available Boc-AA-NH2 and ß-enaminones. This strategy allows the synthesis of a large variety of chiral pyrimidines (18 examples) with good yields from the chiral pool. In the case of peptide isosteres, this procedure proved to be highly stereoretentive and paves the way to the construction of C-terminal modified peptidomimetics as illustrated in the synthesis of two original pyrimidines containing pseudo-dipeptides.