RESUMO
Three hundred ninety-one cases of chronic lymphocytic leukemia (CLL) from the Tumour Registry of Manitoba, spanning a 20-year period from January 1960 to December 1979, were reviewed. Survival curves were developed using the staging systems of Rai and Binet. A clear separation in survival was found utilizing the system of Binet. Also, there was a significant increase in the development of secondary malignancies (observed, 53; expected, 31, p less than 0.01). However, there was no significant increase in secondary malignancies if only those malignancies occurring at least six months after the diagnosis of chronic lymphocytic leukemia was made were analyzed (observed, 38; expected, 29, p = 0.26). This suggests that the increase in secondary malignancies is not treatment-related, and may be due to the underlying disease.
Assuntos
Leucemia Linfoide/mortalidade , Feminino , Humanos , Leucemia Linfoide/patologia , Masculino , Manitoba , Estadiamento de Neoplasias , Prognóstico , Sistema de Registros , Estudos RetrospectivosRESUMO
Manitoba tumour registry data for patients with non-Hodgkin's lymphoma diagnosed between 1968 and 1977 inclusive who were given chemotherapy were reviewed. The Rappaport classification of these tumours enabled general pathologists in the province to distinguish three main prognostic groups. Combination chemotherapy improved survival significantly more than single-agent chemotherapy only for the patients with diffuse histiocytic lymphoma, not for those with diffuse poorly differentiated lymphocytic lymphoma or the more favourable histologic types of non-Hodgkin's lymphoma--diffuse well differentiated lymphocytic and nodular poorly differentiated lymphocytic. For the last two types, therefore, the more intensive chemotherapy is not justified.
Assuntos
Antineoplásicos/uso terapêutico , Linfoma/epidemiologia , Ciclofosfamida/uso terapêutico , Quimioterapia Combinada , Seguimentos , Histiócitos/citologia , Humanos , Linfoma/tratamento farmacológico , Linfoma/mortalidade , Linfoma Folicular/tratamento farmacológico , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Linfoma não Hodgkin/tratamento farmacológico , Manitoba , Prednisona/uso terapêutico , Vincristina/uso terapêuticoRESUMO
Six hundred thirty cases of non-Hodgkin's lymphoma (NHL) in the Tumour Registry of Manitoba spanning an 11-year period from January 1968 to December 1978 were reviewed. There were 34 cancers from 31 individuals who developed the cancer at least six months after diagnosis of NHL. There was no statistical difference in the incidence of second malignancies in this disease compared with an age-matched population in Manitoba. In particular, no cases of acute leukemia were identified.
