1.
J Org Chem
; 67(24): 8679-81, 2002 Nov 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12444659
RESUMO
(+/-)-4,12-Dihydroxy[2.2]paracyclophane [(+/-)-PHANOL] is readily prepared from [2.2]paracyclophane by an improved synthetic protocol. Enzymatic kinetic resolution of its bis-acetate proceeds with good enantioselection. Separation, hydrolysis, and recrystallization provides both enantiomers of PHANOL in high enantiopurity.