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1.
J Pediatr Surg ; 53(2): 302-305, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29229481

RESUMO

AIMS: The laparoscopic approach to tumour nephrectomy in children is controversial. We therefore reviewed our institution's cases of tumour nephrectomy (laparoscopic, open, and converted) to better understand which is suitable for this approach, what factors prevent it, and whether one can excise tumours greater than the CCLG recommendation of 300 ml. METHODS: All tumour nephrectomies performed between 2002 and 2016 were identified using our surgical database. Further data were gathered from radiology and pathology databases. Those with nonrenal tumours or having a partial nephrectomy were excluded. Tumour maximum diameters, volumes, and ratios to contralateral kidneys were calculated. A Mann-Whitney U was used to compare the groups. RESULTS: Forty-three cases were included. Fifteen procedures were completed laparoscopically (35%), and a further 3 converted. The median age at surgery was 2.5 years (range 0-10) in the laparoscopic group and 2 years (range 0-15) in the open group. There was a significant difference (P < 0.05) between the laparoscopic and open groups for: median maximum diameter (10cm vs 12.25cm), median volume (155 ml vs 459 ml), maximum diameter ratio (1.22 vs 1.75), and volume ratio (3.8 vs 11.2). CONCLUSION: Tumours in the laparoscopic group were significantly smaller, but it was possible to excise tumours more than 300 ml. Difficulties in excision related to tumour size relative to the abdomen. Therefore, a ratio of tumour to contralateral kidney may be a better guide to safe excision than an overall volume cutoff. From our series, the laparoscopic approach is likely to be achievable if the volume ratio is ≤ 8.1. LEVEL OF EVIDENCE: Level 3.


Assuntos
Neoplasias Renais/cirurgia , Laparoscopia , Nefrectomia/métodos , Adolescente , Criança , Pré-Escolar , Bases de Dados Factuais , Estudos de Viabilidade , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Retrospectivos , Resultado do Tratamento
2.
J Pediatr Surg ; 49(7): 1083-6, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24952793

RESUMO

BACKGROUND: Despite randomized controlled trials and meta-analyses, it remains unclear whether laparoscopic pyloromyotomy (LP) carries a higher risk of incomplete pyloromyotomy and mucosal perforation compared with open pyloromyotomy (OP). METHODS: Multicenter study of all pyloromyotomies (May 2007-December 2010) at nine high-volume institutions. The effect of laparoscopy on the procedure-related complications of incomplete pyloromyotomy and mucosal perforation was determined using binomial logistic regression adjusting for differences among centers. RESULTS: Data relating to 2830 pyloromyotomies (1802 [64%] LP) were analyzed. There were 24 cases of incomplete pyloromyotomy; 3 in the open group (0.29%) and 21 in the laparoscopic group (1.16%). There were 18 cases of mucosal perforation; 3 in the open group (0.29%) and 15 in the laparoscopic group (0.83%). The regression model demonstrated that LP was a marginally significant predictor of incomplete pyloromyotomy (adjusted difference 0.87% [95% CI 0.006-4.083]; P=0.046) but not of mucosal perforation (adjusted difference 0.56% [95% CI -0.096 to 3.365]; P=0.153). Trainees performed a similar proportion of each procedure (laparoscopic 82.6% vs. open 80.3%; P=0.2) and grade of primary operator did not affect the rate of either complication. CONCLUSIONS: This is one of the largest series of pyloromyotomy ever reported. Although laparoscopy is associated with a statistically significant increase in the risk of incomplete pyloromyotomy, the effect size is small and of questionable clinical relevance. Both OP and LP are associated with low rates of mucosal perforation and incomplete pyloromyotomy in specialist centers, whether trainee or consultant surgeons perform the procedure.


Assuntos
Mucosa Intestinal/lesões , Perfuração Intestinal/etiologia , Laparoscopia/efeitos adversos , Complicações Pós-Operatórias/etiologia , Estenose Pilórica/cirurgia , Piloro/cirurgia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Retrospectivos
3.
J Laparoendosc Adv Surg Tech A ; 23(1): 78-80, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23151113

RESUMO

BACKGROUND: Improved cosmesis is widely recognized as the main benefit of single-port laparoscopy (SPL). Recently, some centers have started to perform SPL in infants and neonates. However, in our experience, the cosmetic result following traditional laparoscopic surgery in this age range is excellent. This study assessed infants' postoperative scars following traditional laparoscopic surgery. SUBJECTS AND METHODS: Ten successive patients who previously underwent transperitoneal dismembered pyeloplasty were invited to attend for photographs of their abdominal wounds. All patients had had a 5-mm infra-umbilical port and two 3.5-mm ports (epigastrium and iliac fossa). Photographs were all taken in the hospital's medical photography studio by the same medical photographer. Life-size photographs were then shown to 10 junior doctors who were asked to identify any visible scars and rate the cosmetic result. RESULTS: Six patients with a median age at surgery of 8 months (range, 4-15 months) attended for photographs a median of 13 months postoperatively (range, 8-19 months). None of the junior doctors was able to identify all three scars on any photo. No individual scar was identifiable by all reviewers. No scars were identified in over half (31) of the total of 60 photograph reviews. Of 180 scar reviews, only 37 (21%) were identified. The umbilical scars were least noticeable (3/60), followed by iliac fossa scars (11/60) and epigastric scars (23/60). Where any scars were correctly identified, the cosmetic result was always rated good (44%) or excellent (56%). CONCLUSIONS: Traditional laparoscopic surgery in infants can have an excellent cosmetic result with "invisible" scars. The cosmetic benefit and thus the role of SPL in infants are therefore questionable.


Assuntos
Cicatriz/etiologia , Laparoscopia/efeitos adversos , Humanos , Lactente
4.
J Pediatr Surg ; 47(3): 601-5, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22424362

RESUMO

AIM: The aim of this study was to determine the risk of complications and conversions for minimally invasive procedures in children, thus allowing properly informed consent. METHODS: Data were retrieved for all minimally invasive surgical procedures performed between 1995 and 2009. RESULTS: There were 2352 cases performed in 2288 (1428 were male) patients. Of these, 2210 cases (94%) were laparoscopic, and 143 (6%), thoracoscopic. The median age at operation was 6 years and 4 months. The overall complication rate was 3.6%, with the risk of early reoperation at 1.7%. The risk was highest for fundoplication and pyloromyotomy at 3.2% and 4%, respectively. The risk of an infective complication was 0.5% and was highest for appendicectomy and nephrectomy. The risk of visceral injury overall in this series was 0.4%. Visceral injury, explicable only by port insertion, occurred in just under 1 in 1000 cases. The conversion rate was 2.3%. The lowest rates were observed with appendicectomy, fundoplication, and pyloromyotomy. Thoracoscopic cases, nephrectomies, and procedures for an underlying oncological diagnosis had a higher conversion rate. CONCLUSION: Informed consent requires knowledge of the risks of surgery. This series may serve as an aid for other units in obtaining consent for minimally invasive surgery in the pediatric population.


Assuntos
Consentimento Livre e Esclarecido , Laparoscopia , Complicações Pós-Operatórias/epidemiologia , Toracoscopia , Criança , Feminino , Humanos , Laparoscopia/estatística & dados numéricos , Masculino , Avaliação de Resultados em Cuidados de Saúde , Reoperação/estatística & dados numéricos , Risco , Toracoscopia/estatística & dados numéricos , Reino Unido
6.
J Laparoendosc Adv Surg Tech A ; 19(5): 687-9, 2009 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19694563

RESUMO

INTRODUCTION: In this article, we present our case series of laparoscopic Heller's myotomies. These were all performed with the aid of intraoperative upper gastrointestinal (GI) endoscopy. MATERIALS AND METHODS: During a 7-year period, 5 patients underwent a laparoscopic Heller's myotomy. There were 4 male patients and 1 female, with an average age of 12.1 years at operation (range, 9.3-14.9). One 14-year-old boy had had a laparoscopic Heller's procedure performed elsewhere and presented with severe dysphagia while undergoing orthopedic surgery in our hospital. His myotomy had been inadequate, and an intraoperative endoscopy had not been performed. All patients had preoperative upper GI contrast studies performed to confirm the diagnosis of achalasia. Two patients had manometry in addition to the contrast study. One patient had been treated with balloon dilatation preoperatively and another with botox injections. Endoscopy was performed pre- and postmyotomy to ensure adequacy. RESULTS: There were no cases of intraoperative mucosal perforation or conversions to an open procedure. Sixty percent of patients required extension of the myotomy after intraoperative endoscopy. All patients had an uneventful, complication-free postoperative recovery. CONCLUSION: We feel that the addition of endoscopy during laparoscopic Heller's myotomy confers a significant advantage in ensuring that the myotomy is adequate. In our experience, the outcome has been excellent even after previous balloon dilatation or submucosal botox injections.


Assuntos
Endoscopia Gastrointestinal/métodos , Acalasia Esofágica/cirurgia , Adolescente , Criança , Feminino , Fundoplicatura/métodos , Humanos , Período Intraoperatório , Laparoscopia
7.
J Laparoendosc Adv Surg Tech A ; 19 Suppl 1: S67-70, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18999976

RESUMO

INTRODUCTION: In this paper, we review our laparoscopic and thoracoscopic experience and look specifically at the cases that resulted in conversion. METHODS: Data were retrieved on all minimally invasive surgical procedures performed in our institution. RESULTS: There were 1,759 cases performed between 1997 and 2007. Of these, 1,648 cases were laparoscopic and 111 thoracoscopic. There were 508 appendicectomies (34 interval), 216 fundoplications (21 redo), 183 diagnostic laparoscopies, 137 pyloromyotomies, 35 cholecystectomies, 27 splenectomies, 98 Fowler-Stephens procedures,79 nephrectomies (including heminephrectomies), 48 Palomo procedures, 75 assisted percutaneous endoscopicgastronomies, 31 pull-through procedures for Hirschsprung's disease, and 210 others. There were 45 conversions (2.6%) over the time period; 40% of all cases converted were in children who had previously had surgery, and 13% of the conversions were enforced due to bleeding or visceral injury at the time of surgery.Looking at the conversion for specific operations, this was 1.4% for appendicectomies, 2% for pyloromyotomies,and 1% for fundoplications. The rate was highest for thoracoscopic cases and nephrectomies at 10%; 82% of all conversions occurred during the first 1,000 cases (56% of our experience). CONCLUSION: Our conversion rate is 2.6%. There has been a significant fall in our conversion rate over the 11 years, despite the increased number, breadth, and complexity of our caseload. We attribute this to the learning curve associated with minimally invasive surgery. Conversion is more common in patients who have had previous surgery, thoracoscopic procedures, and nephrectomies.


Assuntos
Laparoscopia/estatística & dados numéricos , Humanos , Complicações Intraoperatórias , Toracoscopia/estatística & dados numéricos
8.
J Laparoendosc Adv Surg Tech A ; 19 Suppl 1: S167-70, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18999980

RESUMO

UNLABELLED: In this we describe two cases of neonatal malrotation with volvulus treated laparoscopically in our institution.CASE 1: A term baby girl was presented on day 3 of life with malrotation and volvulus. On inspection laparoscopically,the cecum was lying in a subhepatic position to the left of the midline. The small bowel was lying on the right, and there was a 180-degree rotation of the bowel. The rotated bowel was viable and of good color.The bowel was derotated, Ladd's bands divided, and the mesentery broadened. She was up to full feeds by postoperative day 2 and was discharged home on the 3rd day postsurgery.CASE 2: A baby boy presented with malrotation and volvulus on day 11 of life. At laparoscopy, there was freechyle in the peritoneal cavity and a midgut volvulus with an ischemic appearing bowel (with the exception of stomach duodenum and descending colon). The bowel was derotated, the ischemic bowel was returned to a healthy color, and Ladd's bands were divided and the root of the mesentery broadened. On post-operative day 2, he was commenced on feeds (expressed breast milk), and by post-operative 4, the baby was tolerating fullfeeds. CONCLUSION: In our unit, we have performed two laparoscopic Ladd's procedures. Neither of these children have had any complications and, on follow-up, are clinically well with excellent cosmetic results. We feel that laparoscopic treatment of malrotation with volvulus is a feasible procedure and should be performed where the expertise and equipment are available.


Assuntos
Volvo Intestinal/cirurgia , Intestinos/anormalidades , Intestinos/irrigação sanguínea , Isquemia/complicações , Laparoscopia , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Feminino , Humanos , Recém-Nascido , Intestinos/cirurgia , Masculino
9.
Semin Pediatr Surg ; 18(1): 20-2, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19103417

RESUMO

The results of thoracoscopic repair of oesophageal atresia with or without tracheo-oesophageal fistula are presented. Twenty-six children had the repair performed thoracoscopically (22 in Edinburgh and 4 by Edinburgh surgeons in other institutions). Twenty infants had oesophageal atresia with tracheo-oesophageal fistula and 6 had isolated oesophageal atresia without fistula. Details of the technique are presented. Birth weights ranged from 1.4 to 3.9 kg and children were operated between 1 day and three months of age. There were 7 minor anastomotic leaks all managed conservatively, 1 recurrent fistula managed thoracoscopically and 9 anastomotic strictures. One child had a tracheo-bronchial fistula not seen at original thoracoscopy. There were 3 deaths (one child with Edward's syndrome, one with associated congenital diaphragmatic hernia and one late death with severe cardiac disease). Thoracoscopic repair of oesophageal atresia is feasible and the long term outcome appears favorable.


Assuntos
Atresia Esofágica/cirurgia , Toracoscopia , Humanos , Lactente , Recém-Nascido , Fístula Traqueoesofágica/cirurgia
10.
J Pediatr Surg ; 42(4): 735-6, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17448778

RESUMO

Congenital anterior urethral diverticulum is an uncommon condition that tends to present in older children with signs of chronic urinary problems. A neonate presented following recurrent collapse, and cystography revealed a giant urethral diverticulum. The diverticulum was incised at cystoscopy, leading to a full recovery.


Assuntos
Divertículo/congênito , Doenças Uretrais/congênito , Divertículo/diagnóstico , Divertículo/cirurgia , Humanos , Recém-Nascido , Masculino , Doenças Uretrais/diagnóstico , Doenças Uretrais/cirurgia
11.
J Laparoendosc Adv Surg Tech A ; 17(1): 101-7, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17362185

RESUMO

PURPOSE: We describe a modification of the two-stage laparoscopic Fowler-Stephens technique in which the gubernacular vessels are preserved and the testis is brought down the canal via the internal ring. A purely laparoscopic second stage is performed. We report our outcomes with this technique. MATERIALS AND METHODS: All laparoscopic Fowler-Stephens orchidopexies undertaken at our hospital from 1996 to July 2004 were identified from a prospectively collected database of all surgical procedures undertaken in the unit. A retrospective case-note review was undertaken. RESULTS: We identified 21 patients, 4 bilateral and 17 unilateral, giving a total of 25 intra-abdominal testes. Mean age at presentation was 21 months (range, 0-56 months). Mean age at the first stage was 36 months (range, 11-68 months). The testis position at initial laparoscopy was high in 5, close to the internal inguinal ring in 9, peeping in 6, and pelvic in 5. The testis size at this stage was either normal, good sized, or reasonable sized in 15, small or dysplastic in 5, and in 5 the size was not commented upon. The testicular vessels were mainly divided by diathermy at the first stage, but in 6 the vessels were clipped. The second stage was undertaken 6 months after the first, in order to allow the collateral blood supply to adapt. Twelve testes had changed position category during this interval, 2 having ascended to a higher position and 10 descended to a lower position; 12 were in the same position at both stages; and in 1 case the position was not commented upon at the second stage. A purely laparoscopic second stage technique was used in 21 cases; an assisted-open second stage was undertaken in 1 case. In 3 cases the testis was palpable in the groin at examination under anesthesia and so an open second stage orchidopexy was performed. Follow-up was at 6 and 18 months after the second stage. Eighteen of the 21 testes that underwent a purely laparoscopic second stage survived at 6 months, giving a success rate with this technique of 86%. The overall testis survival rate in the entire group at 6 months was 88% (22/25). Findings in those patients reviewed at 18 months were unchanged. CONCLUSION: The two-stage laparoscopic Fowler-Stephens orchidopexy, with preservation of the gubernacular vessels and predominantly using a purely laparoscopic second stage, provided a very good testis survival rate, approaching 90%.


Assuntos
Laparoscopia , Testículo/cirurgia , Criança , Pré-Escolar , Criptorquidismo/cirurgia , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Prospectivos , Testículo/irrigação sanguínea , Resultado do Tratamento
12.
J Laparoendosc Adv Surg Tech A ; 17(1): 131-6, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17362191

RESUMO

PURPOSE: This study evaluated the impact of laparoscopic pyloromyotomy since it came into use at our institution in March 1999. MATERIALS AND METHODS: The recovery profiles and intraoperative and postoperative complications of 170 infants who underwent laparoscopic, semicircumumbilical incision, or right upper quadrant incision pyloromyotomies between March 1999 and April 2005 were analyzed. RESULTS: Eighty-one (48%) of operations were undertaken laparoscopically, 51 (30%) by traditional right upper quadrant incision, and 38 (22%) by semicircumumbilical incision. Patient group demographics were similar across all groups. There was no significant difference in overall complication rate between procedures: laparoscopic group, 12.3% (10/81); semicircumumbilical incision group, 18.4% (7/38); and right upper quadrant incision group, 9.8% (5/51). Early in the laparoscopic series there were 2 inadequate pyloromyotomies and 2 conversions to open procedures due to perforation (n = 1) and poor visibility (n = 1). Infections were more common with open surgery: laparoscopic, 1.2% (n = 1), right upper quadrant incision, 7.8% (n = 4), and semicircumumbilical incision, 13.2% (n = 5). Operative correction was required for herniation at 3 laparoscopic incision sites (3.6%), 2 semicircumumbilical incision sites (5.3%), and 2 right upper quadrant incision sites (3.9%). Patients who underwent laparoscopy returned to full feeds faster (laparoscopic, 18.1 hours; right upper quadrant incision, 28.1 hours; and semicircumumbilical incision, 28.9 hours) (P < 0.05), required less analgesia (laparoscopic, 2.1 doses; right upper quadrant incision, 4.0 doses; and semicircumumbilical incision, 4.3 doses) (P < 0.05), and had less emesis (laparoscopic, 1.6 episodes; right upper quadrant incision, 2.9 episodes; and semicircumumbilical incision, 3.5 episodes) (P < 0.05), resulting in faster discharge (laparoscopic, 2.0 days; right upper quadrant incision, 3.1 days; and semicircumumbilical incision, 3.2 days) (P < 0.05). CONCLUSION: Laparoscopic pyloromytomy is as effective and safe as open procedures and is associated with an improved recovery profile. We conclude that, where laparoscopic skills exist, laparoscopy should be the management of choice for hypertrophic pyloric stenosis.


Assuntos
Laparoscopia/métodos , Estenose Pilórica/cirurgia , Piloro/cirurgia , Feminino , Humanos , Hipertrofia , Lactente , Recém-Nascido , Masculino , Músculo Liso/cirurgia , Complicações Pós-Operatórias , Estenose Pilórica/patologia , Infecção da Ferida Cirúrgica
13.
J Laparoendosc Adv Surg Tech A ; 16(4): 411-3, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16968195

RESUMO

Intestinal perforation in very low birth weight infants with necrotizing enterocolitis has a high morbidity and mortality. We report the use of laparoscopy on day 30 of life in the treatment of a very low birth weight infant (900 g) with perforated necrotizing enterocolitis. The question of laparotomy versus peritoneal drain is ongoing. Laparoscopy may have a major role to play in the answer to this debate. The versatility of laparoscopy enables good visualization of the bowel and organs: a drain can be placed in a port site if there is no fecal contamination and a more conservative approach is warranted, or a conversion to a laparotomy can be undertaken if there are obvious feces or necrotic bowel. We feel that laparoscopy in the initial evaluation of necrotizing enterocolitis is invaluable, and can avoid potentially unnecessary surgery in an already extremely unwell infant.


Assuntos
Drenagem , Enterocolite Necrosante/cirurgia , Perfuração Intestinal/cirurgia , Intestino Delgado/patologia , Intestino Delgado/cirurgia , Laparoscopia , Terapia Combinada , Enterocolite Necrosante/complicações , Feminino , Humanos , Recém-Nascido , Recém-Nascido de muito Baixo Peso , Perfuração Intestinal/etiologia , Intestino Delgado/diagnóstico por imagem , Radiografia Abdominal
14.
Ann Clin Biochem ; 43(Pt 4): 318-9, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16824285

RESUMO

A 3-year-old boy was referred to a regional centre with an acute abdomen. On admission, his abdomen was clinically benign but an extremely high serum amylase titre noted. The patient was treated with simple observation and over the following period he was found to have an inflamed parotid gland.


Assuntos
Amilases/biossíntese , Gastroenteropatias/diagnóstico , Dor Abdominal , Pré-Escolar , Diagnóstico Diferencial , Humanos , Masculino , Pancreatite/diagnóstico , Glândula Parótida/patologia
15.
J Laparoendosc Adv Surg Tech A ; 16(1): 59-62, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16494551

RESUMO

OBJECTIVE: To determine the benefits of nephrectomy in children performed via a retroperitoneoscopic approach compared to the laparoscopic route. MATERIALS AND METHODS: We reviewed all endoscopic nephrectomies performed at our institution from August 1998 to February 2003. RESULTS: A total of 32 endoscopic nephrectomies were undertaken: 22 laparoscopic nephrectomies with 5 conversions to open surgery, and 10 retroperitoneoscopic. The main indication for surgery was poor function secondary to either reflux or obstructive nephropathy. Intraoperative heart rate changes were less marked in patients undergoing retroperitoneoscopic nephrectomy. The median operative time for retroperitoneoscopic nephrectomy was 65 minutes and 95 minutes for laparoscopy. Epidural analgesia was not required in successful endoscopic nephrectomies. The median postoperative morphine requirement in the retroperitoneoscopic group was 110mcg/kg compared to 280mcg/kg in the laparoscopic group. The majority of patients who had successful endoscopic nephrectomies were discharged to home within 2 days of surgery. CONCLUSION: Retroperitoneoscopic nephrectomy appears to be a safe technique in children, with reduced intraoperative physiological effects compared to the laparoscopic approach. Operative time was generally shorter than the laparoscopic approach and there appeared to be an additional benefit of reduced postoperative pain.


Assuntos
Laparoscopia , Nefrectomia/métodos , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino
16.
Pediatr Dev Pathol ; 8(6): 685-9, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16328663

RESUMO

A diagnosis of multiple gastric stromal tumors that were nonmetastatic at presentation was made in an 11-year-old girl who presented with hematemesis. Gastrointestinal stromal tumor (GIST) is a rare diagnosis in childhood and reported multiple lesions are generally seen in the context of familial disease, occasionally with syndromic associations. Although there are no reports of genetic mutation in cases of pediatric GIST, very many cases of multiple GISTs investigated on a molecular level have shown germline KIT or platelet-derived growth factor receptor-alpha mutation; these were familial cases. Despite the negative family history in our patient, the multiplicity of lesions in such a young patient raised concern for a genetic predisposition and prompted extensive molecular workup. Repeat evaluation of distinct aliquots of tumor tissue by polymerase chain amplification followed by sequence analysis of selected coding sequences of KIT and platelet-derived growth factor receptor-alpha previously shown to harbor mutations in GIST, yielded no evidence of even a somatic mutation. This clinically unique case is discussed in the context of a literature review.


Assuntos
Tumores do Estroma Gastrointestinal/genética , Tumores do Estroma Gastrointestinal/patologia , Proteínas Proto-Oncogênicas c-kit/genética , Receptor alfa de Fator de Crescimento Derivado de Plaquetas/genética , Criança , Feminino , Humanos , Mutação , Reação em Cadeia da Polimerase
17.
Pediatr Blood Cancer ; 45(6): 838-40, 2005 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16047363

RESUMO

Acute abdominal complications of chemotherapy are common but the differential diagnosis wide. We describe two cases of intussuception of the bowel in children receiving chemotherapy for acute lymphoblastic leukaemia (ALL) and discuss how a high clinical suspicion is critical for the correct diagnosis to be made rapidly.


Assuntos
Antineoplásicos/efeitos adversos , Intussuscepção/induzido quimicamente , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Criança , Diagnóstico Diferencial , Feminino , Humanos , Intussuscepção/diagnóstico , Intussuscepção/cirurgia , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Resultado do Tratamento
18.
J Pediatr Urol ; 1(4): 301-5, 2005 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18947556

RESUMO

OBJECTIVE: Pelvi-ureteric junction obstruction (PUJO) is one of the commonest causes of paediatric urinary tract obstruction. Open pyeloplasty has always been the reference standard treatment with variable results. Recently, attention has turned to minimally invasive procedures. We reviewed our 8-year experience with endoluminal balloon dilatation to ascertain whether this procedure is an effective minimally invasive alternative. PATIENTS AND METHODS: The hospital databases, case notes, and radiology records of 14 patients who underwent 15 balloon dilatations for PUJO were examined. Patient demographics, clinical presentation, radiological investigations, operative details, morbidity and follow up were noted. RESULTS: The median age was 10.5 years (range 19 months to 14 years); 33% female and 66% male. Nine primary dilatations, five dilatations following open pyeloplasty, and one re-dilatation were performed. The median stenting time was 44 days (range 1-63 days) and the median in-patient stay was 2 days (range 1-17). There were six minor complications due to blocked stents, misplaced stents, or stents falling out. All patients were followed up at 12 months, and nine had further follow up. The median length of follow up was 44 months (range 22-75). Median diameter of the renal pelvis and MAG3 drainage scores improved from 34 to 16 mm and 4 to 3, respectively, from pre-dilatation to most recent follow up. At the most recent follow up, none of the patients had symptoms attributable to PUJO. CONCLUSIONS: Our results suggest that, using specialized techniques and a multidisciplinary surgeon-radiologist approach, balloon dilatation can be an effective alternative to open pyeloplasty.

19.
Pediatr Radiol ; 34(5): 414-6, 2004 May.
Artigo em Inglês | MEDLINE | ID: mdl-15024527

RESUMO

A 14-year-old boy was admitted with absolute dysphagia 1 year after he had swallowed drain cleaner. Contrast swallow showed a tight stricture of the whole of the oesophagus below the level of T2. Attempted dilatation to 8 mm using conventional balloons was performed on two occasions, but there was residual waisting. An 8-mm cutting balloon (Peripheral Cutting Balloon, Boston Scientific) was used to abolish this waisting, and full dilatation to 10 mm was performed in the same procedure. Subsequent serial dilatation to 20 mm has been successful and the patient is now able to swallow normal food with cessation of gastrostomy feeding. This is believed to be the first report of the use of a cutting balloon to treat an oesophageal stricture.


Assuntos
Queimaduras Químicas/terapia , Cateterismo , Estenose Esofágica/terapia , Adolescente , Queimaduras Químicas/diagnóstico por imagem , Queimaduras Químicas/etiologia , Estenose Esofágica/induzido quimicamente , Estenose Esofágica/diagnóstico por imagem , Humanos , Masculino , Radiografia
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