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Arch Dis Child Fetal Neonatal Ed ; 89(1): F61-4, 2004 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-14711859

RESUMO

OBJECTIVE: To determine the effects of chorioamnionitis and antenatal corticosteroids on matrix metalloproteinase-8 (MMP-8) concentrations in bronchoalveolar lavage (BAL) fluid from preterm babies in the first week of life. DESIGN: Prospective observational study. SETTING: Regional neonatal intensive care unit. PATIENTS: Thirty five ventilated preterm babies < 33 weeks gestation, seven of whom were born after chorioamnionitis, which was diagnosed histologically as the presence of inflammatory cells in the chorioamnionic plate. METHODS: MMP-8 was measured by enzyme linked immunosorbent assay (ELISA) in 90 serial BAL samples taken during the first six postnatal days. The median MMP-8 concentration for each baby was calculated. RESULTS: Median MMP-8 concentrations were higher in the chorioamnionitis group than in those without (43 v 5 ng/ml). Partial or complete courses of antenatal corticosteroids had no effect on MMP-8 concentrations. CONCLUSIONS: Higher concentrations of MMP-8 are found in BAL fluid from preterm babies from pregnancies complicated by chorioamnionitis. This type I collagenase may contribute to the lung injury that occurs in some babies with respiratory distress syndrome.


Assuntos
Corticosteroides/efeitos adversos , Líquido da Lavagem Broncoalveolar , Corioamnionite/complicações , Recém-Nascido Prematuro/metabolismo , Metaloproteinase 8 da Matriz/análise , Peso ao Nascer/fisiologia , Ensaio de Imunoadsorção Enzimática/métodos , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Masculino , Troca Materno-Fetal/fisiologia , Gravidez , Cuidado Pré-Natal/métodos , Estudos Prospectivos , Fatores de Risco
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