Avaliação de resistência à insulina e fatores de risco para doenças cardiovasculares em pacientes com vitiligo / Evaluation of insulin resistance and risk factors for cardiovascular diseases in patients with vitiligo

Introdução: A relação entre doença cardiovascular, resistência à insulina e vitiligo tem sido avaliada em estudos. No entanto, ainda não há consenso sobre o assunto. Objetivos: Avaliar a relação entre resistência à insulina e vitiligo, além da prevalência de fatores de risco para doença cardiovascular em adultos com vitiligo quando comparados ao grupo controle. Métodos: Estudo transversal com grupo controle. Foi utilizada uma amostra de conveniência de pacientes consecutivos com 14 anos ou mais. Pacientes e controles foram investigados com exames laboratoriais e medidas antropométricas. Foram calculados os índices LAP, HOMA-IR, e HOMAß. Resultados: Foram incluídos 130 pacientes, 73 com diagnóstico de vitiligo e 57 controles. Não houve diferença significativa entre os grupos quando avaliadas as medidas do LAP, HOMA-IR, e HOMAß. Dentre os fatores de risco para doença cardiovascular, a pressão arterial sistólica foi significativamente maior nos pacientes com vitiligo. Conclusões: Não foi observada maior prevalência de resistência à insulina entre pacientes com vitiligo. Quanto aos fatores de risco para doenças cardiovasculares, apenas a pressão arterial sistólica foi maior nos pacientes com vitiligo. Novos estudos são necessários para elucidar a prevalência de resistência à insulina e fatores de risco cardiovascular em pacientes com vitiligo.

Introduction: The relationship between cardiovascular disease, insulin resistance and vitiligo has been evaluated in studies. However, there is still no consensus on the subject. Objectives: To evaluate the relationship between insulin resistance and vitiligo, in addition to the prevalence of risk factors for cardiovascular disease, in adults with vitiligo when compared to the control group. Methods: Cross-sectional study with a control group. A convenience sample of consecutive patients aged 14 years and over was used. Patients and controls were assessed with laboratory tests and anthropometric measurements. The LAP, HOMA-IR, and HOMAß indices were calculated. Results: We included 130 patients, 73 with a diagnosis of vitiligo and 57 controls. There were no significant differences between groups when LAP, HOMA-IR, and HOMAß were evaluated. Among the risk factors for cardiovascular disease, systolic blood pressure was significantly higher in patients with vitiligo. Conclusions: There was no higher prevalence of insulin resistance among patients with vitiligo. Regarding the risk factors for cardiovascular diseases, only systolic blood pressure was higher in patients with vitiligo. Further studies are needed to elucidate the prevalence of insulin resistance and cardiovascular risk factors in patients with vitiligo.

Association between clinical characteristics, quality of life, and sleep quality in patients with periorbital hyperchromia.

INTRODUCTION: Periorbital hyperchromia (POH) is a multifactorial condition, precipitated or aggravated by sleep disorders, which negatively affects quality of life (QoL). The aim of this study was to evaluate the impact of POH on QoL, sleep quality, and dissatisfaction of affected patients. METHODS: In this cross-sectional study of male and female patients over 18 years, participants were examined, their demographic data were registered, and Dermatology Quality of Life Index (DLQI), Pittsburgh Sleep Quality Index (PSQI-BR), and Visual Analogue Scale (VAS) were used to assess dissatisfaction. RESULTS: Patients (n = 100) were mostly women (91%) with a mean age of 36.9 years and POH duration of 18.32 years. Phototypes II (24%) and III (60%) were predominant. A total of 33% reported 4-6 hours and 66% reported over 6 hours of sleep per night. POH was classified as mild (59%), moderate (37%), or severe (4%). Mean dissatisfaction with POH was 6.9, PSQI was 6.04, and DLQI was 4.92. There was a significant difference in the dissatisfaction scale (P < .005) between men and women. Women reported worse QoL (P < .001) and higher dissatisfaction (P < .0001). A correlation between DLQI and disease duration was found. CONCLUSION: Periorbital hyperchromia negatively impacts patients' QoL. Dissatisfaction is directly related to disease severity.