Association between ADHD symptoms and inhibition-related brain activity using functional near-infrared spectroscopy (fNIRS).

Attention deficit hyperactivity disorder (ADHD) is associated with deficits in inhibitory functions including interference control, inhibition of prepotent/automatic responses and suppression of already initiated responses. This study used functional near-infrared spectroscopy (fNIRS) to investigate the neural basis of these three forms of inhibition assessed by a recently developed behavioral protocol combining the Stroop-matching/stop-signal task in twenty-five young adults with inattention, impulsivity and/or hyperactivity symptoms. The severity of ADHD symptoms was measured using the Adult ADHD Self-Report Scale (ASRS). The concentration of oxygenated hemoglobin (HbO) was assessed in the dorsolateral prefrontal cortex (DLPFC), inferior frontal gyrus (IFG) and temporoparietal regions (TP) during the Stroop-matching/stop-signal task. Correlations yielded significant associations between ASRS scores and HbO concentration in frontal regions during blocks with stop-signal tasks, namely the right IFG, the left DLPFC and the left IFG. This study revealed that different types of inhibition involve unique frontal and temporoparietal activities and linked frontal dysfunction during the suppression of ongoing responses to the severity of ADHD symptoms.

Spatial incompatibility training can prevent the occurrence of the enhanced Simon effect in elderly / Treinamento de incompatibilidade espacial pode prevenir a ocorrência do efeito Simon ampliado em idosos

The Simon effect is typically larger for older people than for young adults, maybe due to age-related decline in inhibitory capabilities. 32 right-handed aged people (5 male, 27 female; mean of 67,1 years ± 5,5) participated in this study. In screening were used the Mini-Mental State Examination and the Center for Epidemiological Study Depression Scale. Then, half of the participants practiced the spatial incompatibility task before the Simon task and the other group was only tested on the Simon task. The analysis of variance considering practice (incompatible, no-practice group) and correspondence (corresponding, non-corresponding) revealed a two-way interaction (F = 7.07; p = 0.012; ηp2 = 0.191) showing that the Simon effect was eliminated in the incompatible practice group, but remained intact in the group with no previous practice. These results indicated that cognitive processes required to the transfer of learning are preserved in elderly, being potentially useful to influence spatial inhibitory capabilities.

O efeito Simon é tipicamente maior em pessoas idosas do que em adultos jovens, talvez devido ao declínio de capacidades inibitórias em função da idade. Participaram deste estudo 32 pessoas idosas e destras (5 homens e 27 mulheres; média de 67,1 anos ± 5,5). Para rastreio, foram usados o Mini Exame do Estado Mental e a escala de depressão do Center for Epidemiological Studies. Metade dos participantes praticou a tarefa de incompatibilidade espacial antes da tarefa de Simon e o outro grupo foi testado apenas na tarefa de Simon. A análise de variância, considerando a prática prévia (incompatível ou sem prática) e correspondência (correspondente, não correspondente), indicou uma interação dupla (F = 7,07; p = 0,012; ηp2 = 0,191), demonstrando que o efeito Simon foi eliminado no grupo de prática incompatível, mas permaneceu ampliado no grupo sem prática anterior. Esses resultados indicaram que os processos cognitivos necessários para transferir a aprendizagem estão preservados em idosos, sendo potencialmente úteis para influenciar as capacidades inibitórias espaciais.

The Stroop-matching task as a tool to study the correspondence effect using images of graspable and non-graspable objects.

The Stroop-matching task is a variation of the Stroop task in which participants have to compare a Stroop stimulus attribute (color or word) to a second stimulus. The Stroop-matching response conflict (SMRC) represents an interference related to the processes involved in selection/execution of manual responses. In the present study, we developed a variation of the Stroop-matching task in which the Stroop stimuli were matched to graspable objects (a cup) with intact or broken handles laterally oriented (Experiment 1) or to colored bars laterally presented (Experiment 2). It allowed testing the presence of the correspondence effect for lateralized handles and bars and its possible influence on SMRC. Two different intervals (100 and 800 ms) were also included to investigate time modulations in behavioral performance (reaction time and accuracy). Fifty-five volunteers participated in the study. In both experiments, significant SMRC was found, but no interaction occurred between SMRC and correspondence effect, supporting that the hypothesis of different and relatively independent psychological mechanisms is at the basis of each effect. Because significant facilitation for ipsilateral motor responses (correspondence effect) occurred for graspable objects but not for lateralized bars, the attentional shift/spatial-coding view was not able to completely explain our data, and therefore, the grasping affordance hypothesis remained as the most plausible explanation. The time course of facilitation observed in the first experiment and by others indicates the importance of further studies to better understand the time dynamic of facilitation/inhibition of motor responses induced by graspable objects.

Inhibitory mechanisms involved in Stroop-matching and stop-signal tasks and the role of impulsivity.

Stroop-like and stop-signal tasks are commonly used to evaluate "inhibition", a multifaceted concept fundamental to better understanding of executive functions. Both tasks demand inhibitory processes for their execution; the first requires inhibition of an irrelevant attribute, while the second involves the inhibition of a prepotent motor response. Impulsivity and decision-making represent two other factors that could be associated to executive control and to inhibitory dyscontrol. In this study we developed a behavioral protocol combining the Stroop-matching (a variation of the classic Stroop task) and the stop-signal tasks to investigate possible interactions between the inhibitory mechanisms involved in both tasks. Moreover, we searched for associations between behavioral performance of healthy participants, and self-reported impulsivity and decision-making processes assessed by the BIS-11 scale and IGT, respectively. Our results showed that the primary-task reaction time in the Stroop-matching task influenced the ability to inhibit motor responses in the stop-signal task. Moreover, impulsiveness scores (but not decision-making) were associated to behavioral performance. Importantly, motor and attentional impulsiveness correlated differently to performance depending on the existence of stop-signal trials in the task. Our protocol revealed promising findings concerning the interaction between different inhibitory processes and their association with impulsivity levels.

The Perception of Aversiveness of Surgical Procedure Pictures Is Modulated by Personal/Occupational Relevance.

It is well established that emotions are organized around two motivational systems: the defensive and the appetitive. Individual differences are relevant factors in emotional reactions, making them more flexible and less stereotyped. There is evidence that health professionals have lower emotional reactivity when viewing scenes of situations involving pain. The objective of this study was to investigate whether the rating of pictures of surgical procedure depends on their personal/occupational relevance. Fifty-two female Nursing (health discipline) and forty-eight Social Work (social science discipline) students participated in the experiment, which consisted of the presentation of 105 images of different categories (e.g., neutral, food), including 25 images of surgical procedure. Volunteers judged each picture according to its valence (pleasantness) and arousal using the Self-Assessment Manikin scale (dimensional approach). Additionally, the participants chose the word that best described what they felt while viewing each image (discrete emotion perspective). The average valence score for surgical procedure pictures for the Nursing group (M = 4.57; SD = 1.02) was higher than the score for the Social Work group (M = 3.31; SD = 1.05), indicating that Nursing students classified those images as less unpleasant than the Social Work students did. Additionally, the majority of Nursing students (65.4%) chose "neutral" as the word that best described what they felt while viewing the pictures. In the Social Work group, disgust (54.2%) was the emotion that was most frequently chosen. The evaluation of emotional stimuli differed according to the groups' personal/occupational relevance: Nursing students judged pictures of surgical procedure as less unpleasant than the Social Work students did, possibly reflecting an emotional regulation skill or some type of habituation that is critically relevant to their future professional work.

Order of stimulus presentation modulates interference in Stroop matching tasks: a reaction time study / Ordem de apresentação de estímulos modula interferências em testes Stroop-pareado: um estudo de tempo de reação / Orden de presentación de estímulos modula interferencias en testes Stroop-pareado: un estudio de tiempo de reacción

In the classic Stroop effect, the time spent to name the color of an incon­gruent stimulus (GREEN in blue) is longer than the time necessary to name the color of a congruent stimulus (BLUE in blue). In the “Stroop matching task”, volunteers are instructed to compare attributes of two stimuli, in which one of them is necessarily a Stroop stimulus. Our aim was to investigate whether the order of stimulus presentation can explain some contradictory results and reveal the imposition of high-order cognitive resources in conflict resolution. Our results confirmed that the strategy adopted in the task depended on the order in which stimuli were presented. In the “Stroop-Bar” order, using the interval between stimuli to solve the conflict inherent to the Stroop stimulus is possible, which is otherwise not possible in the “Bar-Stroop” order. However, these strategies cannot explain the discrepancy in the results reported in the literature.

No teste Stroop clássico, o tempo gasto para nomear a cor de um estímulo incongruente (VERDE em azul) é maior que o necessário para nomear a cor de um estímulo congruente (AZUL em azul). No teste Stroop-Pareado (Stroop matching task), voluntários são instruídos a comparar atributos de dois estímulos, sendo um deles, necessariamente, um estímulo Stroop. Nosso objetivo foi investigar se a ordem de apresentação dos estímulos pode explicar resultados contraditórios e revelar a imposição de recursos de alta ordem na solução de conflitos. Nossos resultados confirmam que a estratégia adotada para desempenhar a tarefa depende da ordem na qual os estímulos foram apresentados. Na ordem “Stroop-Barra”, é possível usar o intervalo entre os estímulos para solucionar o conflito inerente ao estímulo Stroop, o que não é possível na ordem “Barra-Stroop”. No entanto, essas estratégias não conseguem explicar a discrepância de resultados observados na literatura.

En la tarea Stroop clásica, el tiempo utilizado para nombrar el color de un estímulo incongruente (VERDE en azul) es más grande que lo necesario para nombrar el color de un estímulo congruente (AZUL en azul). En una tarea Stroop de comparación (Stroop matching task), voluntarios son instruidos a comparar atributos de dos estímulos, uno de ellos siendo necesariamente un estímulo Stroop. Nuestro objetivo fue investigar si el orden de presentación de los estímulos puede explicar algunos resultados contradictorios y revelar la imposición de recursos de alto orden en la solución­ de conflictos. Nuestros resultados confirman que la estrategia adoptada en la tarea depende del orden en el cual los estímulos fueran presentados. En el orden “Stroop-Barra” es posible utilizar el intervalo entre los estímulos para solucionar el conflicto inherente al estímulo Stroop, lo que no es posible en el orden “Barra-Stroop”. Sin embargo, esas estrategias no consiguen explicar la discrepancia de los resultados observados en la literatura.

Attentional disengagement is modulated by the offset of unpleasant pictures: a saccadic reaction time study.

We studied the influence of passively viewing a picture on saccade latencies to peripheral targets. Thirty-two volunteers were instructed to look at a central picture, wait for the onset of a peripheral target, and execute a saccade toward it as quickly as possible - saccadic reaction time (SRT). The central picture (neutral or unpleasant) could be turned off simultaneously with target onset (the no-gap condition) or 200ms prior to target onset (the gap-200 condition). We found that saccade latencies were influenced by emotional valence and condition. In the no-gap condition, SRTs were longer after viewing unpleasant pictures. In the gap-200 condition, the pattern was reversed, and unpleasant pictures induced shorter SRTs in relation to neutral pictures. Furthermore, the influence of unpleasant pictures gradually decreased when images were re-exposed to the participants - affective habituation. The results are discussed in terms of attentional avoidance and disengagement from unpleasant emotional pictures.

Emotional processing in obsessive-compulsive disorder.

The aim of the present study was to investigate whether there are differences in emotional processing among people with obsessive-compulsive disorder, using Lang's dimensional model of emotions. A total of 22 individuals with obsessive-compulsive disorder participated in the study and were compared to a control group (n=25). All participants assessed a set of photographs with emotional content (pleasant, neutral, unpleasant, and with obsessive-compulsive content) using the Self-Assessment Manikin pictorial scales for rating emotional valence (pleasant/unpleasant), arousal (calm/aroused) and dominance (controlling/controlled). The results show significant differences in the processing of emotional images among individuals with obsessive-compulsive disorder and the high predictive value of dominance for diagnosis.

Stroop matching task: role of feature selection and temporal modulation.

We conducted an event-related potential (ERP) study to investigate the electrocortical dynamics of attentional feature-based processing in the Stroop matching task. Participants in the study (n = 37) compared the ink color of a colored word with the meaning of a color-word in white ink. The two task stimuli were presented simultaneously or with SOAs (Stimulus Onset Asynchrony) of 400 and 1,200 ms. The Stroop matching effect was maximal during SOA-0, was reduced at SOA-400, and was inverted at SOA-1200. We focused the ERP analysis on the N1 component. Paralleling the behavioral results, the N1 amplitude was greater for congruent stimuli than incongruent stimuli during SOA-0. This difference was attenuated at SOA-400, and at SOA-1200, an inverse pattern was observed. The results provide evidence that early selection processing participated in the Stroop matching task phenomenon and also suggest that the temporal modulation of early attention is a function of task characteristics such as SOA.

Alcohol, emotion and attention: revisiting the Alcohol Myopia Theory / Álcool, emoção e atenção: resgatando a Teoria da Miopia Alcoólica

Among the known effects of alcohol on behavior, the modulation of cognitive functions (such as attention and memory), emotion, risk-taking and aggressive behavior are noteworthy. Here, we performed literature review in order to reinterpret alcohol effects on behavior according to the Alcohol Myopia Theory. According to this construct, there is a reduction of attentional resources during alcohol intoxication, which are primarily allocated to the most salient events in a given situation. The consequence is a hyperfocus directed to emotional situations when they are sufficiently relevant to grab attention, or a reduced attentional focus to emotional events in the presence of a relevant demanding task. The understanding of the mechanism mentioned above support the discussion of propositions toward the prevention of problems related to alcohol consumption. Importantly, the attentional allocation model provides inputs for a discussion on the scientifically-supported public health propositions aimed at preventing problems related to acute alcohol intoxication.

Dentre os efeitos associados ao consumo alcoólico, destaca-se a modulação sobre funções cognitivas, como atenção e memória, bem como sobre as emoções, comportamento de risco e agressividade. No presente estudo apresentamos uma revisão crítica da literatura propondo uma reinterpretação para os efeitos comportamentais do álcool com base na teoria da Miopia Alcoólica. Durante a intoxicação, existiria uma redução de recursos atencionais, os quais seriam direcionados para eventos mais relevantes. A repercussão, então, seria um aumento do foco atencional para situações emocionais, quando estas fossem suficientemente relevantes ou, em contrapartida, uma diminuição para tais situações na presença de uma tarefa-alvo demandante. A reinterpretação dos efeitos do álcool, com base na teoria da Miopia Alcoólica, fornece subsídios para a mudança de paradigma na intervenção clínica.

Dynamics of a Stroop matching task: effect of alcohol and reversal with training

Using a Stroop matching task, we evaluated how alcohol affects the time needed to overcome Stroop conflict and whether practice might reverse the effect of alcohol. Participants (n = 16) performed two sessions in which they had to compare the color of a color-word with the meaning of a color-word in neutral color. The two task stimuli were presented simultaneously or with a Stimulus Onset Asynchrony (SOA) of 200, 500, or 800 ms. For half of the subjects, alcohol was administered in the first session, and for the other half, alcohol was administered in the second session. The results showed that the Stroop effect was significant at the 0 and 200 ms intervals in the sober subjects. Moreover, in untrained intoxicated individuals, interference endured until the 500 ms interval, a result that was abolished in trained intoxicated subjects. In conclusion, alcohol increased the time needed for Stroop matching task conflict resolution. However, this deleterious effect was minimized by a previous practice session.

Dynamics of a Stroop matching task: effect of alcohol and reversal with training

Using a Stroop matching task, we evaluated how alcohol affects the time needed to overcome Stroop conflict and whether practice might reverse the effect of alcohol. Participants (n = 16) performed two sessions in which they had to compare the color of a color-word with the meaning of a color-word in neutral color. The two task stimuli were presented simultaneously or with a Stimulus Onset Asynchrony (SOA) of 200, 500, or 800 ms. For half of the subjects, alcohol was administered in the first session, and for the other half, alcohol was administered in the second session. The results showed that the Stroop effect was significant at the 0 and 200 ms intervals in the sober subjects. Moreover, in untrained intoxicated individuals, interference endured until the 500 ms interval, a result that was abolished in trained intoxicated subjects. In conclusion, alcohol increased the time needed for Stroop matching task conflict resolution. However, this deleterious effect was minimized by a previous practice session.(AU)

Alcohol, emotion and attention: revisiting the Alcohol Myopia Theory / Álcool, emoção e atenção: resgatando a Teoria da Miopia Alcoólica

Among the known effects of alcohol on behavior, the modulation of cognitive functions (such as attention and memory), emotion, risk-taking and aggressive behavior are noteworthy. Here, we performed literature review in order to reinterpret alcohol effects on behavior according to the Alcohol Myopia Theory. According to this construct, there is a reduction of attentional resources during alcohol intoxication, which are primarily allocated to the most salient events in a given situation. The consequence is a hyperfocus directed to emotional situations when they are sufficiently relevant to grab attention, or a reduced attentional focus to emotional events in the presence of a relevant demanding task. The understanding of the mechanism mentioned above support the discussion of propositions toward the prevention of problems related to alcohol consumption. Importantly, the attentional allocation model provides inputs for a discussion on the scientifically-supported public health propositions aimed at preventing problems related to acute alcohol intoxication.(AU)

Dentre os efeitos associados ao consumo alcoólico, destaca-se a modulação sobre funções cognitivas, como atenção e memória, bem como sobre as emoções, comportamento de risco e agressividade. No presente estudo apresentamos uma revisão crítica da literatura propondo uma reinterpretação para os efeitos comportamentais do álcool com base na teoria da Miopia Alcoólica. Durante a intoxicação, existiria uma redução de recursos atencionais, os quais seriam direcionados para eventos mais relevantes. A repercussão, então, seria um aumento do foco atencional para situações emocionais, quando estas fossem suficientemente relevantes ou, em contrapartida, uma diminuição para tais situações na presença de uma tarefa-alvo demandante. A reinterpretação dos efeitos do álcool, com base na teoria da Miopia Alcoólica, fornece subsídios para a mudança de paradigma na intervenção clínica.(AU)

Role of attention and translation in conflict resolution: implications for stroop matching task interference

We studied the influence of attention on the timecourse of Stroop-like conflict. Thirty-two volunteers performed a Stroop matching task in which they had to compare either the color (n = 16) or meaning (n = 16) of two stimuli. The first stimulus was always a color-name printed in yellow, red, or blue (i.e., Stroop stimulus), and the second stimulus was either a color-bar (Experiment 1) or color-word in white ink (Experiment 2). Stimulus onset asynchrony (SOA) was varied parametrically. Interference by incongruent Stroop stimuli was clearly modulated by SOA manipulation in both cases. The results are discussed in terms of interactions between translational and attentional models in which the degree of Stroop-like interference is attributed to time implementation of attentional mechanisms during color-to-color and color-to-word matching contexts

Role of attention and translation in conflict resolution: implications for Stroop matching task interference

We studied the influence of attention on the timecourse of Stroop-like conflict. Thirty-two volunteers performed a Stroop matching task in which they had to compare either the color (n = 16) or meaning (n = 16) of two stimuli. The first stimulus was always a color-name printed in yellow, red, or blue (i.e., Stroop stimulus), and the second stimulus was either a color-bar (Experiment 1) or color-word in white ink (Experiment 2). Stimulus onset asynchrony (SOA) was varied parametrically. Interference by incongruent Stroop stimuli was clearly modulated by SOA manipulation in both cases. The results are discussed in terms of interactions between translational and attentional models in which the degree of Stroop-like interference is attributed to time implementation of attentional mechanisms during color-to-color and color-to-word matching contexts.(AU)

Fact or fiction? An event-related potential study of implicit emotion regulation.

Emotion regulation can be achieved through a number of processes. Previous studies have investigated this issue by encouraging individuals to voluntarily change how they think about a situation in order to decrease its emotional impact. However, little is known about automatic regulation processes. The goal of the present study was to investigate whether an "implicit reappraisal strategy" would modulate the Late Positive Potential (LPP) associated to affective picture viewing. Unpleasant pictures, presented as distractors, were shown in two contexts in which a prior description presented them as taken from either movie scenes (fictitious) or real scenes. Results showed that the interference produced by unpleasant pictures under the real context, indexed by reaction time and LPP amplitude, was attenuated under the fictitious context. These results provide evidence for implicit down-regulation of the stimulus relevance during an inattention condition.

Comparação de desempenho de jogadores de voleibol e não esportistas em tarefas de orientação automática e voluntária da atenção visual: um estudo exploratório / Comparing performance of volleyball players and non sport practing people on volluntary and automatic orienting visual attention tasks: an exploratory study / Comparación del desempeño de jugadores de voleibol y no deportistas en tereas de orientación automática y voluntaria de la atención visual: un estudio exploratorio

Atenção é a seleção de informações que terão prioridade de processamento pelo sistema nervoso. Este trabalho avaliou o tempo de reação (TR) de 6 jogadores do voleibol e 6 não esportistas, em tarefas de orientação voluntária e automática da atenção. No Experimento I (voluntária), aparecia o ponto de fixação (PF) e, após 700 ms, uma seta (válida, inválida ou neutra) surgia no centro e indicava à direita ou à esquerda. Após 300, 500 ou 800 ms, surgia o alvo. No Experimento II (automática), aparecia um PF, e, após 700 ms, um quadrado brilhava. Depois de 100 ou 800 ms, piscava o alvo na mesma posição ou em posição oposta. O participante respondia pressionando uma tecla. Ao final, as medianas dos TR foram submetidas à Anova. No Experimento I, observou-se que jogadores foram mais rápidos que não esportistas (p < 0,05), diferentemente do que ocorreu no Experimento II (p = 0,36). Os resultados indicam que jogadores de voleibol apresentam melhor desempenho em tarefas de orientação voluntária da atenção.

Attention is the selection of information to improve central nervous system functioning. In this study, reaction times (RT) of 6 volleyball players and 6 non sports practitioners were compared during voluntary and automatic orienting of attention tasks. In Experiment I (voluntary) a central fixation point (FP) appeared and after 700 ms a central cue (valid, invalid or neutral) indicating to the left or to the right. After 300, 500 or 800 ms the target flashed. In Experiment II (automatic), after 700 ms a peripheral cue appeared and after 100 or 800 ms the target appeared on the same or the opposite cue position. Subjects responded by pressing a joystick key. Median RT for each condition were used in Anova. The analysis of Experiment I demonstrated that volleyball players were faster than non sports practitioners (p < 0.05), differently of Experiment II (p = 0.36). These results indicate that volleyball players had better performance on voluntary attentional tasks.

Atención es la selección de informaciones que tendrán prioridad de procesamiento por el sistema nervioso. Esto estudio evaluó el tiempo de reacción (TR) de 6 jugadores de voleibol y 6 no-deportistas en tareas de orientación voluntaria y automática de la atención. En el Experimento I (voluntaria) aparecía el punto de fijación (PF) y tras 700 ms, una flecha (válida, inválida o neutral) indicaba la derecha o la izquierda. Después de 300, 500 o 800 ms surgía el blanco. En el Experimento II (automática) aparecía un PF y tras 700 ms un cuadrado brillaba. Después de 100 o 800 ms parpadeaba el blanco en la misma posición o en la posición opuesta. El participan e respondía apretando una tecla. Al final las medianas de los TR fueron sometidas a Anova. En el Experimento I, los jugadores fueron más rápidos que los no-deportistas (p < 0,05), diferentemente de lo que ocurrió en el Experimento II (p = 0,36). Los resultados indican que los jugadores de voleibol tienen mejor desempeño en tareas de orientación voluntaria de atención.

Regulation of negative emotions in high trait anxious individuals: an ERP study

Literature has shown that failures in the ability to down-regulate negative emotions are the core substrate of anxiety disorders. Previous studies have investigated this issue by encouraging individuals to voluntarily change how they think about a situation in order to decrease its emotional impact. The majority of studies has demonstrated that explicit instructions to reduce negative affect in anxious individuals are usually ineffective. Thus, the goal of the present study was to investigate whether an implicit regulation strategy would modulate electrophysiological activity (Late Positive Potential) associated to affective picture viewing. The Late Positive Potential (LPP) is a sustained positive deflection in the event-related potential that is larger following the presentation of emotional compared to neutral visual stimuli. Participants (low trait anxious - LTA and high trait anxious - HTA individuals) performed an attention task (bar orientation discrimination) while emotional distractive pictures were presented. The task was performed in two different contexts: in the Real context, participants were informed that the distractive pictures had been obtained from real life situations, whereas in the Fictitious context they were told that the pictures had been obtained from movie scenes. In this vein, we encouraged participants to change how they appraised the pictures. Results showed that HTA individuals exhibited larger Late Positive Potential (LPPs) when mutilation pictures were presented in the Real context. Importantly, during the Fictitious one (regulation strategy) the LPP was reduced even in HTA individuals, emphasizing its importance to psychotherapeutic interventions. The present results indicate that HTA individuals are susceptible to modifications in affective contexts.

Regulation of negative emotions in high trait anxious individuals: an ERP study

Literature has shown that failures in the ability to down-regulate negative emotions are the core substrate of anxiety disorders. Previous studies have investigated this issue by encouraging individuals to voluntarily change how they think about a situation in order to decrease its emotional impact. The majority of studies has demonstrated that explicit instructions to reduce negative affect in anxious individuals are usually ineffective. Thus, the goal of the present study was to investigate whether an implicit regulation strategy would modulate electrophysiological activity (Late Positive Potential) associated to affective picture viewing. The Late Positive Potential (LPP) is a sustained positive deflection in the event-related potential that is larger following the presentation of emotional compared to neutral visual stimuli. Participants (low trait anxious - LTA and high trait anxious - HTA individuals) performed an attention task (bar orientation discrimination) while emotional distractive pictures were presented. The task was performed in two different contexts: in the Real context, participants were informed that the distractive pictures had been obtained from real life situations, whereas in the Fictitious context they were told that the pictures had been obtained from movie scenes. In this vein, we encouraged participants to change how they appraised the pictures. Results showed that HTA individuals exhibited larger Late Positive Potential (LPPs) when mutilation pictures were presented in the Real context. Importantly, during the Fictitious one (regulation strategy) the LPP was reduced even in HTA individuals, emphasizing its importance to psychotherapeutic interventions. The present results indicate that HTA individuals are susceptible to modifications in affective contexts.(AU)

Neurobiologia da regulação emocional: implicações para a terapia cognitivo-comportamental / Neurobiology of emotion regulation: implications for cognitive-behavioral therapy / Neurobiología de la regulación emocional: implicaciones para la terapia cognitivo-conductual

A regulação das emoções representa uma habilidade fundamental para a interação social, influenciando o comportamento e a expressão emocional. É objetivo deste artigo revisar os trabalhos científicos sobre as diferentes estratégias de regulação da emoção e os circuitos cerebrais subjacentes. Os trabalhos que utilizaram a estratégia de reavaliação cognitiva observaram um padrão de ativação cerebral caracterizado por uma ativação significativa do córtex pré-frontal e uma diminuição da ativação da amígdala, sugerindo que o primeiro poderia estar modulando a atividade da última. Trabalhos recentes observaram que mudanças cognitivas e comportamentais mediadas pela psicoterapia parecem levar a alterações na ativação de circuitos cerebrais envolvendo o córtex pré-frontal, e apontam para a possibilidade de modificação de associações neurais observadas em pacientes com transtornos psiquiátricos. Conclui-se que os estudos sobre a neurobiologia da regulação da emoção têm implicações potenciais para a compreensão das bases psicopatológicas subjacentes aos transtornos psiquiátricos, orientando desenvolvimentos heurísticos e clínicos.

Emotion regulation represents a crucial ability for social interaction, guiding behavior and modulating emotional expression. Current essay reviews the available literature on emotion regulation, points out the different coping strategies and investigates the underlying neural network. Studies on cognitive reappraisal of emotion have noted a pattern of brain response characterized by the activation of the prefrontal cortex associated with the reduction of amygdala activity. A modulatory mechanism between these structures has been suggested. Recent work showed that psychotherapeutic approaches may modify the dysfunctional neural circuitry associated with psychiatric disorders. Results show that investigating the neurobiology of emotion regulation offers a potential repercussion on the understanding of the basis of psychiatric disorders, orienting the development of applied studies and improving their clinical relevance.

La regulación emocional se constituye en un elemento clave en el comportamiento social, regulando las acciones y la expresión emocional. Este estudio tiene el propósito de revisar las estrategias de regulación emocional y describir los mecanismos cerebrales que las apoyan. Los estudios que han investigado la actividad cerebral durante la reevaluación cognitiva han mostrado la activación de zonas de la corteza prefrontal y la reducción de la activación de la amígdala, indicando que la primera podría estar modulando la última. Además, estudios recientes han observado que las alteraciones cognitivas y en el comportamiento tras psicoterapia conductual llevan a cambios en la activación de circuitos cerebrales, lo que sostendría la regulación emocional deficiente observada en trastornos mentales. Creemos que el estudio de la regulación emocional como un aspecto del procesamiento afectivo tiene importantes implicaciones para la psicopatología, y puede representar un modelo para el desarrollo de procedimientos de intervención.