RESUMO
Results of treatment of 52 patients with mesenchymal tumours of the mediastinum. Clinical finding is various and nonspecific. Computer tomography and MRT are the most informative diagnostic techniques. Among 52 patients with mesenchymal tumours of the mediastinum, 40 patients were treated surgically and 12 patients got conservative treatment. Chemotherapy and radiotherapy were carried out in 7 patients in pre- and postoperative periods. Radical surgical treatment was carried out in 21 patients with benign tumors. Among 19 patients with malignant tumors, 42% of patients got radical surgical treatment, and 58 % of patients got palliative therapy in combination with chemotherapy. Benign tumors have a favorable prognosis after surgical treatment. Major factors of the prognosis of surgical treatment are dissemination and the histologic form of a tumor as well as type of surgical intervention. Re-operation is necessary in case of relapse.
Assuntos
Neoplasias do Mediastino/cirurgia , Mediastinoscopia/métodos , Mesenquimoma/cirurgia , Cirurgia Torácica Vídeoassistida/métodos , Adolescente , Adulto , Idoso , Feminino , Seguimentos , Humanos , Imageamento por Ressonância Magnética , Masculino , Neoplasias do Mediastino/diagnóstico , Mesenquimoma/diagnóstico , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Some prognostic signs of surgical treatment of carcinoma of the lung are analysed. The stability and paramount importance of the integral clinical factor "extension of the tumor" is shown. The ultrastructural features of adenocarcinoma and squamous-cell carcinoma of the lungs influencing the disease prognosis were revealed. It is shown that electron microscopy allows differentiation of the tumor cells to be profoundly and precisely assessed. The results of the study unable a differentiated approach to the problems of postoperative therapy.
Assuntos
Adenocarcinoma/cirurgia , Carcinoma de Células Pequenas/cirurgia , Carcinoma de Células Escamosas/cirurgia , Neoplasias Pulmonares/cirurgia , Adenocarcinoma/mortalidade , Adenocarcinoma/patologia , Adulto , Idoso , Carcinoma de Células Pequenas/mortalidade , Carcinoma de Células Pequenas/patologia , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/patologia , Feminino , Seguimentos , Humanos , Neoplasias Pulmonares/mortalidade , Neoplasias Pulmonares/patologia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Moscou/epidemiologia , Estadiamento de Neoplasias , Pneumonectomia/métodos , Pneumonectomia/mortalidade , Pneumonectomia/estatística & dados numéricos , PrognósticoAssuntos
Resistência a Medicamentos , Glutationa Transferase/antagonistas & inibidores , Glutationa/antagonistas & inibidores , Leucemia P388/patologia , Animais , Antimetabólitos Antineoplásicos/uso terapêutico , Butionina Sulfoximina , Doxorrubicina/uso terapêutico , Leucemia P388/tratamento farmacológico , Masculino , Metionina Sulfoximina/análogos & derivados , Metionina Sulfoximina/uso terapêutico , Camundongos , Células Tumorais CultivadasAssuntos
Angioplastia , Brônquios/cirurgia , Neoplasias Pulmonares/cirurgia , Adenocarcinoma/cirurgia , Adenocarcinoma Bronquioloalveolar/cirurgia , Idoso , Anastomose Cirúrgica , Tumor Carcinoide/cirurgia , Carcinoma Adenoide Cístico/cirurgia , Carcinoma de Células Escamosas/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
This paper deals with data on 65 patients with multiple primaries. There were synchronous and metachronous, double carcinomas of the esophagus (8), carcinomas of the esophagus and stomach (18), esophagus and lung (10), and stomach and lung (29). Problems of diagnosis and treatment results are discussed. Indications for surgery should be determined by the extent of the two primaries. Only radical surgery with extirpation of both tumors may lead to relatively favorable results. The treatment only of single carcinoma (either by surgery, or radio- and chemotherapy) is not beneficial in patients with synchronous lesions. Thorough attention should be given to the patient's complaints and adequate follow-up investigation pursued in order to detect second (and following) primaries as soon as possible.
