Bipolar spectrum in prostate cancer patients and its role in stress related symptoms.

BACKGROUND: Studies show significant co-occurrence of bipolar disorder and prostate cancer, as well as the presence of shared genes associated with both diseases. Our aim was to evaluate whether prostate cancer patients present bipolar spectrum symptoms and to establish their possible associations with stress related symptoms during diagnosis and the course of the cancer therapy. METHODS: 200 participants were enrolled to this study: 100 prostate cancer patients and 100 healthy males. Bipolar spectrum symptoms were measured with the use of Mood Disorder Questionnaire and Hypomania Checklist-32 (HCL-32). Stress related symptoms were rated with The Impact of Events Scale-Revised (IES-R), Perceived Stress Scale-10 (PSS-10) and Generalised Self-Efficacy Scale (GSES). RESULTS: In comparison to healthy controls group, prostate cancer patients have shown higher HCL-32 scores. Mood Disorder Questionnaire measures were associated with more severe stress related to prostate cancer diagnosis and treatment reflected by higher scores of IES-R and its subscales (Avoidance, Intrusions and Hyperarousal). Mood Disorder Questionnaire, HCL-32, PSS-10, IES-R and GSES measures were not associated with clinical characteristics of prostate cancer severity. LIMITATIONS: Cross-sectional study model precluded identification of causal relationship among variables. Bipolar spectrum symptoms and stress related measures were based on auto-questionnaires. CONCLUSIONS: To our best knowledge, this is the first study evaluating bipolar spectrum symptoms in prostate cancer patients. We have shown that this clinical group presents increased bipolarity traits compared to healthy individuals. Moreover, bipolar spectrum symptoms were associated with more severe stress related to the prostate cancer diagnosis and its treatment, reflected in avoidance, hyperarousal, and intrusions.

Graph Analysis of Verbal Fluency Tests in Schizophrenia and Bipolar Disorder.

Verbal Fluency Tests (VFT) are one of the most common neuropsychological tasks used in bipolar disorder (BD) and schizophrenia (SZ) research. Recently, a new VFT analysis method based on graph theory was developed. Interpreting spoken words as nodes and every temporal connection between consecutive words as edges, researchers created graph structures, allowing the extraction of more data from participants' speech, called Speech Graph Attributes (SGA). The aim of our study was to compare speech graphs, derived from Phonemic and Semantic VFT, between SZ, BD, and healthy controls (HC). Twenty-nine SZ patients, twenty-nine BD patients, and twenty-nine HC performed Semantic and Phonemic VFT. Standard measures (SM) and 13 SGA were analyzed. SZ patients' Semantic VFT graphs showed lower total word count and correct responses. Their graphs presented less nodes and edges, higher density, smaller diameter, average shortest path (ASP), and largest strongly connected component than the HC group. SM did not differentiate BD and HC groups, and patients' Semantic VFT graphs presented smaller diameter and ASP than HC. None of the parameters differentiated BD and SZ patients. Our results encourage the use of speech graph analysis, as it reveals verbal fluency alterations that remained unnoticed in the routine comparisons of groups with the use SM.

Impulsiveness and cyclothymic traits of affective temperament as predictors of risky gambling behavior. / Impulsywnosc i cechy cyklotymiczne temperamentu afektywnego jako predyktory ryzykownych zachowan hazardowych.

OBJECTIVES: To investigate bipolar traits and impulsiveness in pathological gamblers, compared to non-pathological gamblers and non-gambling general population. To investigate interaction between traits of affective temperament, impulsiveness and the severity of pathological gambling. METHODS: 139 participants (63 women, 76 men; mean age: 30.32; SD = 10.69) were included in the study. The Barratt Impulsiveness Scale was used to evaluate impulsiveness and the Temperament Evaluation of Memphis, Pisa and San Diego Autoquestionnaire was used to evaluate affective temperamental traits. The participants were also screened for bipolar affective disorder spectrum using the Mood Disorder Questionnaire and the Hypomania Checklist-32.The Canadian Problem Gambling Index (CPGI) was used to evaluate the severity of pathologicalgambling in the assessed population. Polish versions of the questionnaires were filled out anonymously via the internet. RESULTS: Pathological gamblers (N =36) scored higher on ?Motor impulsiveness', ?Cyclothymic'and ?Irritability'subscales versus non-pathological gamblers (N =61) and non-gamblers (N = 42). Cyclothymic and motor impulsiveness significantly predicted CPGI scores. Motor impulsiveness was found to moderate the influence of cyclothymic affective temperamental traits on pathological gambling. CONCLUSIONS: Our data support prior reports of higher impulsivity traits and traits from the bipolar spectrum among pathological gamblers. The results indicate that the influence of affective temperamental traits on pathological gambling severity is moderated by impulsiveness.